Results 71 to 80 of about 196,311 (276)
Lipid Metabolism at Membrane Contacts: Dynamics and Functions Beyond Lipid Homeostasis
Frontiers in Cell and Developmental Biology, 2020 Membrane contact sites (MCSs), regions where the membranes of two organelles are closely apposed, play critical roles in inter-organelle communication, such as lipid trafficking, intracellular signaling, and organelle biogenesis and division.
Jiesi Xu, Xun Huang, Xun Huang
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The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice
eLife, 2023 The acrosome is a membranous organelle positioned in the anterior portion of the sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles toward nascent acrosome which is regulated by a ...
Ke Xu +17 more
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Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
PHOTOCONTROL OF ORGANELLE BIOGENESIS IN Euglena [PDF]
Photochemistry and Photobiology, 1990 The purpose of this review is to summarize recent work on the photocontrol of chloroplast, mitochondrial and microbody biogenesis in Euglena in the context of light being one of a number of potential sources of carbon and energy for ...
openaire +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
MamF-like proteins are distant Tic20 homologs involved in organelle assembly in bacteria
Nature CommunicationsOrganelle-specific protein translocation systems are essential for organelle biogenesis and maintenance in eukaryotes but thought to be absent from prokaryotic organelles.
Anja Paulus +7 more
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Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g [PDF]
, 2009 Crista junctions (CJs) are important for mitochondrial organization and function, but the molecular basis of their formation and architecture is obscure.
Baumeister, Wolfgang +40 more
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Birth of an organelle: molecular mechanism of lipid droplet biogenesis
, 2023 Lipid droplets (LDs) are cellular organelles regulating energy and lipid metabolism. Generated in the endoplasmic reticulum (ER) by phase separation of neutral lipids (e.g., triglycerides), nascent LDs resemble lens-shaped blisters, grow into spherical ...
Nieto, Vincent +3 more
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Advanced Materials, EarlyView.Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello +5 more
wiley +1 more source
ABCD Meeting “Organelle Biogenesis and Signal Transduction”
, 2016 An ubiquitin-proteasome-endocytic pathway but not autophagy orchestrates ErbB2 internalization and cleavage in HSP90-inhibited breast cancer ...
Cortese K. +5 more
core +1 more source