Results 91 to 100 of about 196,311 (276)

A study of mitochondrial biogenesis in the rodent nervous system [PDF]

, 2015
This thesis investigates the process of mitochondrial biogenesis in the rodent CNS in the context of neuroinflammatory and neurodegenerative disease. There is mounting evidence of mitochondrial damage in neuroinflammation but very little is known about ...
Desai, R
core  

40S ribosome biogenesis co-factors are essential for gametophyte and embryo development [PDF]

, 2013
Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in ...
Roman Martin, Martin, Roman, Roman Martin (85483), Simm, Stefan, Markus T. Bohnsack, Markus T Bohnsack, Benjamin L. Weis (277837), Stefan Simm, Sandra Missbach (277836), Markus T. Bohnsack (277840), Benjamin L Weis, Enrico Schleiff, Weis, Benjamin L., Sandra Missbach, Bohnsack, Markus, Mißbach, Sandra, Stefan Simm (277838), Schleiff, Enrico, Enrico Schleiff (49377), Lafontaine, Denis, Bohnsack, Markus T., Ra Missbach, Benjamin L. Weis   +22 more
core   +2 more sources

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

The architecture of EMC reveals a path for membrane protein insertion

eLife, 2020
Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its ...
John P O'Donnell, Ben P Phillips, Yuichi Yagita, Szymon Juszkiewicz, Armin Wagner, Duccio Malinverni, Robert J Keenan, Elizabeth A Miller, Ramanujan S Hegde   +8 more
doaj   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Lipid Droplet and Peroxisome Biogenesis: Do They Go Hand-in-Hand?

Frontiers in Cell and Developmental Biology, 2019
All eukaryotic cells contain membrane bound structures called organelles. Each organelle has specific composition and function. Some of the organelles are generated de novo in a cell.
Amit S. Joshi, Sarah Cohen
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Synchronous spatiotemporal control of autophagy and organelle trafficking is necessary for infection by Magnaporthe oryzae

Cell Reports
Summary: The blast fungus Magnaporthe oryzae infects plants using an appressorium that generates force to breach the leaf cuticle. Appressorium development follows a cell-cycle-regulated morphogenetic program requiring autophagy-associated death of the ...
Alice B. Eseola, Xia Yan, Lauren S. Ryder, Miriam Osés-Ruiz, Martin J. Egan, Dan MacLean, Nicholas J. Talbot   +6 more
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source