Results 141 to 150 of about 108,308 (280)
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Mitochondrial Biogenesis and Turnover
, 2008 Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover.
Diaz, Francisca, Moraes, Carlos T
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Components Involved in Peroxisome Import, Biogenesis, Proliferation, Turnover, and Movement
, 1998 Subramani, Suresh. Components Involved in Peroxisome Import, Biogenesis, Proliferation, Turnover, and Movement. Physiol. Rev. 78: 171–188, 1998.
SURESH SUBRAMANI
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Nature CommunicationsPhotosynthesis genes in plant chloroplasts are transcribed by the plastid-encoded RNA polymerase called PEP. Consequently, PEP-deficient mutants cannot generate a photosynthetic apparatus and develop non-viable albino seedlings. Inducible complementation
Finia Uecker +3 more
doaj +1 more source
Model of organelle turnover during LPS administration in rat heart.
, 2013 TFEB pathway of autophagosomal and lysosomal biogenesis is activated in the heart to facilitate the elimination of damaged mitochondria during LPS administration. CoPPIX enhances the pathway and accelerates organelle turnover.
Takeshi Funakoshi (283276) +4 more
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, 2014 Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from
Walther, T. +3 more
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Mechanism of precise intracellular targeting of spontaneously inserting tail-anchored proteins
, 2016 Tail-anchored (TA) proteins are membrane proteins that are targeted to their destination by unique post-translational pathways. Cytochrome b5 is a spontaneously inserted TA protein, of which two forms are known: one targeting the ER (b5-ER) and other ...
B.G. Figueiredo Costa +3 more
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International Journal of Cancer, EarlyView.Although lenvatinib is the current first‐line therapy for radioiodine‐refractory differentiated thyroid carcinoma, its use is limited by severe side effects and reduced sensitivity. Here, the authors assessed the potential of sensitizing differentiated thyroid carcinoma tumor cells with limited lenvatinib responsiveness through the administration of ...
Celina Ablinger +13 more
wiley +1 more source
Chloroplast biogenesis: diversity and regulation of the protein import apparatus
, 2009 The biogenesis of chloroplasts is dependent on the coordinate expression of genes encoded in both nuclear and plastid genomes. The chloroplast protein import machinery plays key roles in organelle biogenesis by mediating the import and assembly of ...
Schnell, Danny J., Kessler, Félix
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Interdisciplinary Medicine, EarlyView.Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen +5 more
wiley +1 more source