Results 41 to 50 of about 108,308 (280)

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells

, 2008
The protein product of the ocular albinism type 1 gene, named OA1, is a pigment cell-specific G protein-coupled receptor exclusively localized to intracellular organelles, namely lysosomes and melanosomes.
Bennett, DC, Venturi C, Palmigiano, A, Schiaffino, MV, Piccirillo, R, Altimare D., Rotondo G., Tacchetti, C, Marigo, V, Bagnato P., Coppola M., Rotondo, G, Venturi, C, Sviderskaya, EV, Palmisano I., Palmigiano A., Altimare D, Bagnato, P, Marigo V., Surace, EM, Altimare, D, Tacchetti C, Innamorati G., Venturi C., Surace E. M., Palmisano I, Rotondo G, INNAMORATI, Giulio, BALLABIO, ANDREA, Schiaffino M. V., Sviderskaya E. V., Palmigiano A, Innamorati G, SURACE, Enrico Maria, Sviderskaya EV, Piccirillo R, Bagnato P, Ballabio A., Incerti B, Piccirillo R., Tacchetti C., Schiaffino MV, Coppola, M, Incerti, B, Bennett DC, Incerti B., Palmisano, I, Coppola M, Bennett D. C., Innamorati, G, Ballabio, A, Marigo V   +51 more
core   +1 more source

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

eLife, 2022
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes.
Megan Okada, Krithika Rajaram, Russell P Swift, Amanda Mixon, John Alan Maschek, Sean T Prigge, Paul A Sigala   +6 more
doaj   +1 more source

Astroglia proliferate upon the biogenesis of tunneling nanotubes via α-synuclein dependent transient nuclear translocation of focal adhesion kinase

iScience
Summary: Astroglia play crucial neuroprotective roles by internalizing pathogenic aggregates and facilitating their degradation. Here, we show that α-SYN protofibril-induced organelle toxicities and reactive oxygen species (ROS) cause premature cellular ...
Abinaya Raghavan, Rachana Kashyap, P. Sreedevi, Sneha Jos, Suchana Chatterjee, Ann Alex, Michelle Ninochka D’Souza, Mridhula Giridharan, Ravi Muddashetty, Ravi Manjithaya, Sivaraman Padavattan, Sangeeta Nath   +11 more
doaj   +1 more source

Coordination of plant mitochondrial biogenesis: keeping pace with cellular requirements.

Frontiers in Plant Science, 2014
Plant mitochondria are complex organelles that carry out numerous metabolic processes related with the generation of energy for cellular functions and the synthesis and degradation of several compounds.
Elina eWelchen, Lucila eGarcía, Natanael eMansilla, Daniel H Gonzalez   +3 more
doaj   +1 more source

Inheritance and biogenesis of organelles in the secretory pathway

Nature Reviews Molecular Cell Biology, 2007
In eukaryotic cells, cellular functions are compartmentalized into membrane-bound organelles. This has many advantages, as shown by the success of the eukaryotic lineage, but creates many problems for cells, such as the need to build and partition these organelles during cell growth and division.
Lowe, Martin; id_orcid 0000-0002-9331-8143, Barr, Francis A.   +1 more
openaire   +5 more sources

Maelstrom functions in the production of Siwi-piRISC capable of regulating transposons in Bombyx germ cells

iScience, 2022
Summary: PIWI-interacting RNAs (piRNAs) bind to PIWI proteins to assemble the piRISC, which represses germline transposons. Maelstrom (Mael) is necessary for piRISC biogenesis in germ cells, but its function remains unclear.
Yurika Namba, Yuka W. Iwasaki, Kazumichi M. Nishida, Hidenori Nishihara, Tetsutaro Sumiyoshi, Mikiko C. Siomi   +5 more
doaj   +1 more source

Birth of an organelle: molecular mechanism of lipid droplet biogenesis

, 2023
Lipid droplets (LDs) are cellular organelles regulating energy and lipid metabolism. Generated in the endoplasmic reticulum (ER) by phase separation of neutral lipids (e.g., triglycerides), nascent LDs resemble lens-shaped blisters, grow into spherical ...
Nieto, Vincent, Crowley, Jackson, Santos, Denys, Monticelli, Luca   +3 more
core   +1 more source

ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites

mBio, 2018
Plasmodium parasites and related pathogens contain an essential nonphotosynthetic plastid organelle, the apicoplast, derived from secondary endosymbiosis.
Marta Walczak, Suresh M. Ganesan, Jacquin C. Niles, Ellen Yeh   +3 more
doaj   +1 more source

Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance

, 2015
Additional supplementary file for eLife article "Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance" (2014, eLife 2014;3:e02678, doi: 10.7554/eLife.02678).
eLife Sciences (710207), Shankar Mukherji (828635), Erin K O'Shea (55441)   +2 more
core   +1 more source

TFAP2 transcription factors are regulators of lipid droplet biogenesis

eLife, 2018
How trafficking pathways and organelle abundance adapt in response to metabolic and physiological changes is still mysterious, although a few transcriptional regulators of organellar biogenesis have been identified in recent years.
Cameron C Scott, Stefania Vossio, Jacques Rougemont, Jean Gruenberg   +3 more
doaj   +1 more source