Expression and Function of Organic Cation Transporter 2 in Pancreas [PDF]
Frontiers in Cell and Developmental Biology, 2021 Organic cation transporters (OCT) play an important role in mediating cellular uptake of several pharmaceuticals, such as the antidiabetic drug metformin and the platinum-derived chemotherapeutics.
Sandra Schorn +6 more
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Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker? [PDF]
MetabolitesBackground/Objectives: The impact of potential precipitant drugs on plasma or urinary exposure of endogenous biomarkers is emerging as an alternative approach to evaluating drug–drug interaction (DDI) liability.
Anoud Sameer Ailabouni +5 more
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Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2) [PDF]
Frontiers in Pharmacology, 2023 Introduction: The human organic cation transporter 2 (OCT2) is involved in the transport of endogenous quaternary amines and positively charged drugs across the basolateral membrane of proximal tubular cells.
Max Maane +5 more
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The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus [PDF]
eLife, 2022 Dopamine is a key catecholamine in the brain and kidney, where it is involved in a number of physiological functions such as locomotion, cognition, emotion, endocrine regulation, and renal function.
Natasha M Puri +4 more
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Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity. [PDF]
Int J Mol Sci, 2021 The search of substrates for solute carriers (SLCs) constitutes a major issue, owing notably to the role played by some SLCs, such as the renal electrogenic organic cation transporter (OCT) 2 (SLC22A2), in pharmacokinetics, drug–drug interactions and drug toxicity. For this purpose, substrates have been proposed to be identified by their cis-inhibition
Lefèvre CR +6 more
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The Role of NF-kB in the Downregulation of Organic Cation Transporter 2 Expression and Renal Cation Secretion in Kidney Disease [PDF]
Frontiers in Medicine, 2022 Organic cation transporter 2 (OCT2), encoded by the SLC22A2 gene, is the main cation transporter on the basolateral membrane of proximal tubular cells. OCT2 facilitates the entry step of the vectorial transport of most cations from the peritubular space ...
Chao Han +11 more
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Organic cation transporter 2 contributes to SSRI antidepressant efficacy by controlling tryptophan availability in the brain [PDF]
Translational Psychiatry, 2023 Selective serotonin reuptake inhibitors (SSRI) are common first-line treatments for major depression. However, a significant number of depressed patients do not respond adequately to these pharmacological treatments.
Alejandro Orrico-Sanchez +10 more
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Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives. [PDF]
Int J Mol Sci, 2022 The human organic cation transporter 2 (hOCT2) mediates renal and neuronal cellular cisplatin and oxaliplatin uptake, and therefore plays a significant role in the development of side effects associated with these chemotherapeutic drugs. Autophagy is induced by cisplatin and oxaliplatin treatment and is believed to promote cell survival under stressful
Eltayeb SA +4 more
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Molecular and cellular physiology of organic cation transporter 2. [PDF]
Am J Physiol Renal Physiol, 2019 Organic cation transporters play a critical role in mediating the distribution of cationic pharmaceuticals. Indeed, organic cation transporter (OCT)2 is the initial step in the renal secretion of organic cations and consequently plays a defining role in establishing the pharmacokinetics of many cationic drugs. Although a hallmark of OCTs is their broad
Wright SH.
europepmc +3 more sources
Extended Intake of Mulberry Leaf Extract Delayed Metformin Elimination via Inhibiting the Organic Cation Transporter 2 [PDF]
Pharmaceutics, 2020 Diabetes mellitus (DM) has become a major health problem in most countries of the world. DM causes many complications, including hyperglycemia, diabetic ketoacidosis, and death. In Asia, mulberry has been used widely in the treatment of DM.
Hyun Wook Huh +10 more
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