Results 51 to 60 of about 58,238 (258)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Mediating effect of perceived organisational support on authentic leadership and work engagement

open access: yesSA Journal of Human Resource Management, 2020
Orientation: High levels of employee engagement are critical in the current globally competitive landscape. Scholarly research suggests that authentic leadership (AL) increases trust and ultimately work engagement.
Theresa Vermeulen, Caren B. Scheepers
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Challenges and support behind dual roles: Implications for female lecturers’ performance and academic careers in East Nusa Tenggara, Indonesia

open access: yesSA Journal of Human Resource Management
Orientation: Female lecturers in Indonesia, particularly in regions with strong sociocultural norms such as East Nusa Tenggara, face complex intersections between domestic responsibilities and professional expectations.
Rosadalima Tisu   +2 more
doaj   +1 more source

Female employees' perceptions of organisational support for breastfeeding at work: findings from an Australian health service workplace

open access: yesInternational Breastfeeding Journal, 2011
Background Women's return to work can be a significant barrier to continued breastfeeding. Workplace policies and practices to promote and support continued, and longer duration of, breastfeeding are important. In the context of the introduction of a new
Weber Danielle   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The Role of Ghanaian Media Organisations in Fostering Resilience Against PTSD: The Case of Multimedia Group Limited

open access: yesJournalism and Media
Negativity as a news value in journalism often implies direct or indirect exposure of journalists to traumatic events in the course of their duties. Hence, the need for resiliency and protection of journalists through organisational support has been ...
Gifty Appiah-Adjei
doaj   +1 more source

The Relationship between Caring for Employees and the Well-being of the Organisation

open access: yesOrganizacijų Vadyba: Sisteminiai Tyrimai, 2020
The aim of this paper is to better understand the meaning of caring for employees at the organisational level as well as to disclose its relationship with the well-being of the organisation.
Poškienė Eglė   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Home - About - Disclaimer - Privacy