Results 31 to 40 of about 85,597 (305)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Scientific Opinion on application (EFSA-GMO-BE-2011-101) for the placing on the market of herbicide-tolerant genetically modified oilseed rape MON 88302 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto [PDF]

EFSA Journal, 2014
Oilseed rape MON 88302 was developed by Agrobacterium tumefaciens-mediated transformation to express the CP4 EPSPS protein, which confers tolerance to glyphosate.
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Scientific Opinion on the assessment of potential impacts of genetically modified plants on non-target organisms

, 2010
The European Food Safety Authority (EFSA) asked the Panel on Genetically Modified Organisms to establish a self-tasking Working Group with the aim of (1) producing a scientific review of the current guidance of the GMO Panel for Environmental Risk ...
EFSA Panel on Genetically Modified Organisms (GMO)
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cytokinin-GLK regulatory module promotes the acquisition of photosynthetic activity and cell cycle re-entry in a green-flower mutant of Narcissus tazetta var. chinensis

Frontiers in Plant Science
Floral organs typically function as heterotrophic tissues, heavily reliant on imported photoassimilates for respiration and development. However, under specific genetic or environmental conditions, they can reacquire photosynthetic capabilities. Here, we
Wen-Hui Zhang, Wen-Hui Zhang, Fu-Jian Zhang, Feng Gao, Feng Gao, Zhen-Jun Li, Zhen-Jun Li, Li-Juan Wang, Li-Juan Wang, Bo Wang, Bo Wang, Ri-He Peng, Ri-He Peng, Yong-Dong Deng, Yong-Dong Deng, Quan-Hong Yao, Quan-Hong Yao   +16 more
doaj   +1 more source

Scientific Opinion on application (EFSA‐GMO‐NL‐2008‐52) for the placing on the market of herbicide tolerant genetically modified soybean A5547‐127 for food and feed uses, import and processing under Regulation (EC) No 1829–2003 from Bayer CropScience

EFSA Journal, 2011
This scientific opinion is an evaluation of a risk assessment for the genetically modified herbicide tolerant soybean A5547‐127 for food and feed uses, import and processing. Soybean A5547‐127 was developed through particle bombardment.
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Scientific Opinion on application (EFSA-GMO-UK-2008-53) for the placing on the market of herbicide tolerant genetically modified maize 98140 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Pioneer Overseas Corporation [PDF]

EFSA Journal, 2013
Maize 98140 contains a single insert consisting of the gat4621 and the Zm-hra expression cassettes, providing herbicide tolerance. Bioinformatic analyses and genetic stability studies did not raise safety issues.
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Genetically Modified Organisms and Visceral Leishmaniasis [PDF]

Frontiers in Immunology, 2014
Vaccination is the most effective method of preventing infectious diseases. Since the eradication of small pox in 1976, many other potentially life compromising if not threatening diseases have been dealt with subsequently. This event was a major leap not only in the scientific world already burdened with many diseases but also in the mindset of the ...
Rudra Chhajer, Nahid Ali
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source