Results 21 to 30 of about 78,532 (255)

Scientific Opinion on application (EFSA‐GMO‐UK‐2007‐49) for the placing on the market of the insect resistant and herbicide tolerant genetically modified maize Bt11×GA21 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Syngenta Seeds

EFSA Journal, 2009
This scientific opinion reports on an evaluation of a risk assessment for placing on the market the genetically modified insect resistant and herbicide tolerant maize Bt11×GA21 for food and feed uses, import and processing.
EFSA Panel on Genetically Modified Organisms
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

RNAi-Mediated Silencing of vATPase Subunit E Impairs Larval Development in Plutella xylostella, and Virtual Screening Identifies a Potential Inhibitor

Insects
The diamondback moth (Plutella xylostella) is a devastating global pest of cruciferous crops. This study explores the potential of targeting the vacuolar ATPase subunit E (PxvATPaseE) for its control.
Xuetao Yu, Jinhua Luo, Jiayi Xue, Lin Lu, Pan Deng, Li Zhu, Kang Yang, Xia Wan, Yuhua Wu, Akmal Boboev, Gang Wu, Xiaohong Yan, Chenhui Shen   +12 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Scientific Opinion updating the risk assessment conclusions and risk management recommendations on the genetically modified insect resistant maize MON 810 [PDF]

EFSA Journal, 2012
Following a request from the European Commission, the Panel on Genetically Modified Organisms of the European Food Safety Authority (EFSA GMO Panel) compiled its previous risk assessment conclusions and risk management recommendations on the genetically ...
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Scientific Opinion on application (EFSA‐GMO‐NL‐2008‐52) for the placing on the market of herbicide tolerant genetically modified soybean A5547‐127 for food and feed uses, import and processing under Regulation (EC) No 1829–2003 from Bayer CropScience

EFSA Journal, 2011
This scientific opinion is an evaluation of a risk assessment for the genetically modified herbicide tolerant soybean A5547‐127 for food and feed uses, import and processing. Soybean A5547‐127 was developed through particle bombardment.
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Scientific Opinion on application (EFSA-GMO-UK-2009-76) for the placing on the market of soybean MON 87769 genetically modified to contain stearidonic acid, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto [PDF]

EFSA Journal, 2014
Soybean MON 87769 was developed using Agrobacterium tumefaciens transformation and was intended to modify the lipid profile of the extracted oil. Soybean MON 87769 contains a single insert consisting of the Pj.D6D gene encoding the Δ6 desaturase protein ...
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source