Results 21 to 30 of about 77,933 (256)
iScience, 2023 Summary: PARP1 contributes to genome architecture and DNA damage repair through its dynamic association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA and recruit the DNA repair machinery.
Jyothi Mahadevan +6 more
doaj +1 more source
iScience, 2022 Summary: Podosomes, an important actin-based adhesive architecture, play critical roles in cell migration and matrix invasiveness. Here, we elucidate the ultrastructural organization and regulation of podosome clusters in primary macrophages.
Fen Hu +10 more
doaj +1 more source
Contrasting Views of Complexity and Their Implications For Network-Centric Infrastructures [PDF]
, 2010 There exists a widely recognized need to better understand and manage complex “systems of systems,” ranging from biology, ecology, and medicine to network-centric technologies.
Alderson, David L., Doyle, John C.
core +2 more sources
Understanding Multicellularity: The Functional Organization of the Intercellular Space [PDF]
, 2019 The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration,
Bich, Leonardo +2 more
core +10 more sources
iScience, 2022 Summary: Hsp70 is a key molecular chaperone in the protein quality control system to safeguard protein homeostasis in cells. Previous studies have shown that Hsp70 chaperones TDP-43, a pathogenic protein associated with amyotrophic lateral sclerosis (ALS)
Yichen Li +8 more
doaj +1 more source
Mammalian telomeres and their partnership with lamins [PDF]
, 2016 Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA +2 more
core +1 more source
CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity
iScience, 2021 Summary: CHIP is an E3-ubiquitin ligase that contributes to healthy aging and has been characterized as neuroprotective. To elucidate dominant CHIP-dependent changes in protein steady-state levels in a patient-derived human neuronal model, CHIP function ...
Catarina Dias +9 more
doaj +1 more source
iScienceSummary: Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellular homeostasis, and disease progression.
Pei-Li Tseng +7 more
doaj +1 more source
Wiring optimization explanation in neuroscience: What is Special about it? [PDF]
, 2019 This paper examines the explanatory distinctness of wiring optimization models in neuroscience. Wiring optimization models aim to represent the organizational features of neural and brain systems as optimal (or near-optimal) solutions to wiring ...
Barberis, Sergio Daniel
core +6 more sources
Integrated analysis of glycan and RNA in single cells
iScience, 2021 Summary: Single-cell sequencing has emerged as an indispensable technology to dissect cellular heterogeneity but never been applied to the simultaneous analysis of glycan and RNA.
Fumi Minoshima +3 more
doaj +1 more source