Results 31 to 40 of about 77,933 (256)

Motility at the origin of life: Its characterization and a model

, 2013
Due to recent advances in synthetic biology and artificial life, the origin of life is currently a hot topic of research. We review the literature and argue that the two traditionally competing "replicator-first" and "metabolism-first" approaches are ...
Froese, Tom, Ikegami, Takashi, Virgo, Nathaniel   +2 more
core   +1 more source

Computational Cancer Biology: An Evolutionary Perspective [PDF]

, 2016
ISSN:1553-734XISSN:1553 ...
A Deutsch, A Fischer, A Gonzalez-Perez, A Roth, A Schuh, A Tofigh, A Trinh, AM Newman, BJ Raphael, C Guichard, C Tomasetti, C Tomasetti, CD Greenman, Chris D. Greenman, CO Nordling, CS Cooper, CS-O Attolini, E Purdom, E Szczurek, ER Fearon, F Michor, F Ronquist, F Strino, F Vandin, H Shahrabi Farahani, H Zare, I Bozic, I Bozic, I Martincorena, J Diaz, J Foo, J Rahnenführer, J Shendure, Jens Lagergren, JH Goldie, K Yuan, KI Kim, L Oesper, LJ Barber, LMF Merlo, LR Yates, M Consequences, M Gerlinger, M Gerstung, M Gerstung, M Gerstung, M Hjelm, M Kimmel, MDM Leiserson, MDM Leiserson, MDM Leiserson, MF Berger, MS Lawrence, N Beerenwinkel, N Beerenwinkel, N Beerenwinkel, N Crosetto, N Navin, NE Navin, Niko Beerenwinkel, P Armitage, P Eirew, P Haccou, PC Nowell, PS Larson, R Desper, R Durrett, RF Schwarz, Ruth Nussinov, S Constantinescu, S Nik-Zainal, S Nik-Zainal, S Turajlic, S Turajlic, SA Chowdhury, SA Chowdhury, SE Luria, T Sakoparnig, V Almendro, W Jiao, WJ Ewens, Y Iwasa   +81 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A nucleation distance sets the cell size-dependent P-body assembly in yeast

iScience
Summary: Cells rely on diverse intracellular structures, including phase-separated granules, to regulate biological processes. Processing bodies (P-bodies) are membraneless cytoplasmic condensates that mediate mRNA degradation and storage. Although their
Xuefang Gu, Hamza El Alami, Dexin Shen, Xing Quan, Tatsuhisa Tsuboi   +4 more
doaj   +1 more source

Norm-Establishing and Norm-Following in Autonomous Agency [PDF]

, 2013
Living agency is subject to a normative dimension (good-bad, adaptive-maladaptive) that is absent from other types of interaction. We review current and historical attempts to naturalize normativity from an organism-centered perspective, identifying two ...
Barandiaran, Xabier, Egbert, Matthew
core  

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Myosin cluster dynamics determines epithelial wound ring constriction

iScience
Summary: Collection of myosin motors and actin filaments can self-assemble into submicrometric clusters under the regulation of RhoA. Emergent dynamics of these clusters have been reported in a variety of morphogenetic systems, ranging from Drosophila to
Alka Bhat, Rémi Berthoz, Simon Lo Vecchio, Coralie Spiegelhalter, Shigenobu Yonemura, Olivier Pertz, Daniel Riveline   +6 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Cryo-ET of actin cytoskeleton and membrane structure in lamellipodia formation using optogenetics

iScience
Summary: Lamellipodia are sheet-like protrusions essential for cell migration and endocytosis, but their ultrastructural dynamics remain poorly understood because conventional electron microscopy lacks temporal resolution.
Hironori Inaba, Tsuyoshi Imasaki, Kazuhiro Aoyama, Shogo Yoshihara, Hiroko Takazaki, Takayuki Kato, Hidemasa Goto, Kaoru Mitsuoka, Ryo Nitta, Takao Nakata   +9 more
doaj   +1 more source

Proceedings ICPW'07: 2nd International Conference on the Pragmatic Web, 22-23 Oct. 2007, Tilburg: NL [PDF]

, 2007
Proceedings ICPW'07: 2nd International Conference on the Pragmatic Web, 22-23 Oct.

core