Results 41 to 50 of about 6,516 (293)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Losing and Regaining Organizational Attractiveness During the Recruitment Process: A Multiple-Segment Factorial Vignette Study

Journal of Work and Organizational Psychology, 2022
How applicants’ perceptions of organizational attractiveness (OA) change over the recruitment process and whether OA, once lost, can ever be regained, has hardly been investigated.
Sabrina Krys, Udo Konradt
doaj   +1 more source

Organizational configuration of hospitals succeeding in attracting and retaining nurses [PDF]

Journal of Advanced Nursing, 2006
Abstract Title. Organizational configuration of hospitals succeeding in attracting and retaining nurses Aim.  This paper contrasts structural and managerial characteristics of low‐ and high‐turnover hospitals, and describes the organizational configuration of attractive hospitals.Background.
S. Stordeur, W. D'Hoore, H. M. Hasselhorn, B. H. Müller, P. Tackenberg, A. Kümmerling, M. Simon, A. Büscher, W. D'Hoore, S. Stordeur, L. Braeckman, P. Kiss, R. Verpraet, M. Laine, G. Wickström, M. Estryn Behar, O. Le Nezet, D. Gould, D. Camerino, P. Conway, B. Van der Heijden, E. van der Schoot, H. Oginska, J. Pokorski, P. Radkiewicz, M. Widerszal Bazyl, A. Hanzlikova, M. Kovarova, M. Josephson, P. Lindberg   +29 more
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Organizational Attractiveness, Emotional Labor, and Happiness at Work: A Study Among Physical Education Teachers

Research in Sports Science
The aim of this study was to examine organizational attractiveness, emotional labor, and happiness at work among physical education teachers and to determine whether these variables differ according to demographic characteristics.
Ali Kaya
doaj   +1 more source

Mediating role of organizational attractiveness on the relationship between green recruitment and job pursuit intention among students of Universiti Teknologi Malaysia

Cogent Business & Management, 2020
The purpose of this study was to investigate whether green recruitment practice attracts prospective candidates to join environmental responsible firms through organizational attractiveness.
Muhammad Hamza Khan, Syaharizatul Noorizwan Muktar   +1 more
doaj   +1 more source

CSR fit and organizational attractiveness for job applicants

International Journal of Organizational Analysis, 2021
Purpose The purpose of this paper is to explore a conceptual model on the influence of corporate social responsibility (CSR) “fit” on organizational attractiveness among job applicants under the boundary conditions of chief executive officer (CEO) activism and CSR credibility.
Agnihotri A, Bhattacharya S
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Powder Optimization Strategies for Binder Jetting Printing of BaTiO3 and Ba0,6Sr0,4TiO3 Ceramics

Advanced Engineering Materials, EarlyView.
Powder optimization is investigated to enable binder jetting of BaTiO3 and Ba0.6Sr0.4TiO3 ferroelectric ceramics. The antagonistic relationship between flowability and binder compatibility is addressed through binder impregnation of granulated powders and fumed silica addition to fine powders.
Fanny Pruvost, Lionel Presmanes, Soléna Colin, Marie Vidal, Sophie Guillemet‐Fritsch   +4 more
wiley   +1 more source