Results 31 to 40 of about 4,200 (256)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Organizational configuration of hospitals succeeding in attracting and retaining nurses [PDF]

Journal of Advanced Nursing, 2006
Abstract Title. Organizational configuration of hospitals succeeding in attracting and retaining nurses Aim.  This paper contrasts structural and managerial characteristics of low‐ and high‐turnover hospitals, and describes the organizational configuration of attractive hospitals.Background.
S. Stordeur, W. D'Hoore, H. M. Hasselhorn, B. H. Müller, P. Tackenberg, A. Kümmerling, M. Simon, A. Büscher, W. D'Hoore, S. Stordeur, L. Braeckman, P. Kiss, R. Verpraet, M. Laine, G. Wickström, M. Estryn Behar, O. Le Nezet, D. Gould, D. Camerino, P. Conway, B. Van der Heijden, E. van der Schoot, H. Oginska, J. Pokorski, P. Radkiewicz, M. Widerszal Bazyl, A. Hanzlikova, M. Kovarova, M. Josephson, P. Lindberg   +29 more
openaire   +3 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

STRATEGIES FOR MANAGING THE COMPANY'S POTENTIAL TO INCREASE THE ENTERPRISE'S INVESTMENT ATTRACTIVENESS

Baltic Journal of Economic Studies, 2023
The subject of the study is a complex of theoretical and methodological provisions and practical recommendations on increasing the effectiveness of the formation and use of the potential of enterprise management strategies through the creation and ...
Oleksandr Amosha, Volodymyr Velychko, Vladyslava Troian   +2 more
doaj   +1 more source

CSR fit and organizational attractiveness for job applicants

International Journal of Organizational Analysis, 2021
Purpose The purpose of this paper is to explore a conceptual model on the influence of corporate social responsibility (CSR) “fit” on organizational attractiveness among job applicants under the boundary conditions of chief executive officer (CEO) activism and CSR credibility.
Agnihotri A, Bhattacharya S
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Organizational Attractiveness, Emotional Labor, and Happiness at Work: A Study Among Physical Education Teachers

Research in Sports Science
The aim of this study was to examine organizational attractiveness, emotional labor, and happiness at work among physical education teachers and to determine whether these variables differ according to demographic characteristics.
Ali Kaya
doaj   +1 more source

It was great, they were all young! Is there ageism in students’ reflections on professional internship? [PDF]

Slovenský Národopis, 2018
Noting the tendency of students of work and organizational psychology to choose internships among a smaller number of hosting organizations paired with satisfaction with completed internship expressed by the sentence ‘It was great, they were all young ...
Ivana B. Petrović, Svetlana Čizmić, Milica Vukelić   +2 more
doaj   +1 more source