Results 111 to 120 of about 7,718,571 (348)

Leaders\u2019 competence and warmth: Their relationships with employees\u2019 well-being and organizational effectiveness [PDF]

open access: yes, 2017
The aim of this work was to investigate competence and warmth \u2014 the two basic dimensions of social judgment \u2014 as dimensions employees use to evaluate their supervisors.
Bobbio, Andrea   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Diagnóstico socio-psicológico de la efectividad organizacional en una empresa de BioCubaFarma Social-psychological diagnosis of organizational effectiveness in a BioCubaFarma company

open access: yesRevista Cubana de Salud y Trabajo, 2023
Introducción: Uno de los retos constantes de las organizaciones es alcanzar mayor efectividad, en tal sentido su abordaje científico asume diferentes puntos de vista, vinculando la efectividad a otros constructos como productividad, sostenibilidad, y ...
Martha de la Caridad González Cruz   +2 more
doaj  

Análise comparativa de modelos de alinhamento estratégico Comparative analysis of strategic alignment models

open access: yesProduction, 2009
Este trabalho se insere no campo de pesquisa em estratégia organizacional e apresenta uma revisão e análise comparativa dos modelos de alinhamento estratégico. A relevância deste estudo está relacionada à importância da execução da estratégia no contexto
Vanderli Correia Prieto   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Towards an Integrated Framework for Corporate Entrepreneurship

open access: yesProblemy Zarządzania, 2016
Drawing on a resource-based perspective as well as strategic entrepreneurship theory, this empirical study examines how the performance effect of corporate entrepreneurship is mediated by firm strategy and task contingency regarding key environmental ...
Katarzyna Bratnicka   +1 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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