Results 41 to 50 of about 7,574,805 (294)

La Innovación Organizativa y de Gestión como Motor de Dinamización Empresarial

Journal of Technology Management & Innovation, 2013
Management, also called organizational innovation is an essential driver of business renewal, notably in the case of service firms, where technological innovations and scientifically based R&D are of less relevance than in manufacturing. In this article,
Eva Parga-Dans, Carlos Martín-Ríos, Felipe Criado-Boado   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The psychometric properties of a workplace boredom scale (DUBS) within the South African context

SA Journal of Industrial Psychology, 2016
Orientation: Boredom at work has been shown to be a concern for individuals and organisations. At the time of this research, no validated scale was available to measure and investigate workplace boredom within the South African context. Research purpose:
Sumarie M. van Wyk, Leon T. de Beer, Jaco Pienaar, Wilmar B. Schaufeli   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A Guiding Conceptual Framework for Individualized Knowledge Management Model Building

Management Dynamics in the Knowledge Economy, 2018
This paper presents a conceptual framework for use, by organizational researchers, knowledge management practitioners and business analysts, as a guide to building Knowledge Management (KM) models.
Enis ELEZI, Christopher BAMBER
doaj  

Perceived Medical School stress of undergraduate medical students predicts academic performance: an observational study

BMC Medical Education, 2017
Background Medical students are exposed to high amounts of stress. Stress and poor academic performance can become part of a vicious circle. In order to counteract this circularity, it seems important to better understand the relationship between stress ...
Thomas Kötter, Josefin Wagner, Linda Brüheim, Edgar Voltmer   +3 more
doaj   +1 more source

International Energy Security Risk Index—Analysis of the Methodological Settings

Energies, 2020
The main objective of this paper is to analyze model settings of the International Energy Security Risk Index developed by the U.S. Chamber of Commerce.
Iztok Podbregar, Goran Šimić, Mirjana Radovanović, Sanja Filipović, Polona Šprajc   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source