Results 11 to 20 of about 10,956 (235)
Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists [PDF]
Molecules, 2022 Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the outcome of a therapeutic regime.
ANDREA MILELLI +2 more
core +3 more sources
Catalysing (organo-)catalysis: Trends in the application of machine learning to enantioselective organocatalysis. [PDF]
Beilstein J Org ChemOrganocatalysis has established itself as a third pillar of homogeneous catalysis, besides transition metal catalysis and biocatalysis, as its use for enantioselective reactions has gathered significant interest over the last decades.
Schmid SP +3 more
europepmc +2 more sources
ScienceOpen Research, 2015 Organocatalysis, that is the use of small organic molecules to catalyse organic transformations, has been included among the most successful concepts in asymmetric catalysis and it has been used for the enantioselective construction of C-C, C-N, C-O, C-S,
Chiara Palumbo
doaj +5 more sources
Recent Advances in the Enantioselective Radical Reactions
Molecules, 2023 The review covers research published since 2017 and is focused on enantioselective synthesis using radical reactions. It describes recent approaches to the asymmetric synthesis of chiral molecules based on the application of the metal catalysis, dual ...
Tomasz Bauer +2 more
doaj +1 more source
Concentration-Flux-Steered Mechanism Exploration with an Organocatalysis Application [PDF]
Isr. J. Chem. 63 (2023) e202200123, 2022 Investigating a reactive chemical system with automated reaction network exploration algorithms provides a more detailed picture of its chemical mechanism than what would be accessible by manual investigation. In general, exploration algorithms cannot uncover reaction networks exhaustively for feasibility reasons.
arxiv +1 more source
Electroredox carbene organocatalysis with iodide as promoter
Nature Communications, 2022 Oxidative carbene organocatalysis has been developed as a versatile synthetic method, but has been paired with electroredox chemistry in only limited examples.
Peng Zhou +3 more
doaj +1 more source
New advances in asymmetric organocatalysis II. [PDF]
Beilstein J Org ChemŠebesta R.
europepmc +2 more sources
Molecules, 2023 Through the lens of organocatalysis and phase transfer catalysis, we will examine the key components to calculate or predict catalysis-performance metrics, such as turnover frequency and measurement of stereoselectivity, via computational chemistry.
Choon Wee Kee
doaj +1 more source
Whole Cells as Biocatalysts in Organic Transformations
Molecules, 2018 Currently, the power and usefulness of biocatalysis in organic synthesis is undeniable, mainly due to the very high enantiomeric excess reached using enzymes, in an attempt to emulate natural processes.
Fabián Garzón-Posse +3 more
doaj +1 more source