Results 41 to 50 of about 12,256 (221)
Molecules, 2019 Chirality is one of the most important attributes for its presence in a vast majority of bioactive natural products and pharmaceuticals. Asymmetric organocatalysis methods have emerged as a powerful methodology for the construction of highly ...
Zhonglei Wang
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Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists
Molecules, 2022 Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the outcome of a therapeutic regime.
Efraim Reyes +2 more
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Organocatalysis in total synthesis [PDF]
, 2015 Peer ...
Herrera, Raquel P. +1 more
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Do We Need Asymmetric Organocatalysis?
CHIMIA, 2007 Asymmetric organocatalysis is a 'fast lane' of the chemical highway: the progress in the last decade is simply spectacular. This introductory article summarizes basic principles, historical background, and discusses basic catalyst classes and ...
Peter I. Dalko
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Development of a general, enantioselective organocatalytic Mukaiyama-Michael reaction with α,β-unsaturated aldehydes [PDF]
, 2009 LUMO-lowering organocatalysis has been extended to promote the conjugate addition of S-alkyl and 1-pyrrolyl silylketene acetals to α,β-unsaturated aldehydes, yielding both, syn and anti Mukaiyama–Michael products with high levels of enantioselectivity ...
Borths, Christopher J. +2 more
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Pursuing Chemical Efficiency by Using Supported Organocatalysts for Asymmetric Reactions under Aqueous Conditions [PDF]
, 2015 Over the past decade, a great effort has been made by the chemical community to improve the efficiency of organic transformations and allow sustainable processes.
Alonso, Diego A. +6 more
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Advances in asymmetric organocatalysis over the last 10 years
Nature Communications, 2020 Organocatalysis has become a major pillar of (asymmetric) catalysis. Here, the authors discuss recent trends in organocatalytic activation modes for challenging stereoselective transformations and the emerging integration with other fields, such as ...
Shao-Hua Xiang, Bin Tan
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Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis
Nature Communications, 2022 The ability to construct multiple stereocenters in a modular fashion is an important goal of synthetic organic chemistry. Here the authors present a method to construct oxindoles in four stereoisomers with high enantioselectivity and diastereoselectivity
Yu-Hua Wen +4 more
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Reaction Mechanism of Organocatalytic Michael Addition of Nitromethane to Cinnamaldehyde: A Case Study on Catalyst Regeneration and Solvent Effects [PDF]
, 2017 The Michael addition of nitromethane to cinnamaldehyde has been computationally studied in the absence of a catalyst and the presence of a biotinylated secondary amine by a combined computational and experimental approach. The calculations were performed
Luk, Louis Y. P. +4 more
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Molecules, 2023 In 1971, chemists from Hoffmann-La Roche and Schering AG independently discovered a new asymmetric intramolecular aldol reaction catalyzed by the natural amino acid proline, a transformation now known as the Hajos–Parrish–Eder–Sauer–Wiechert reaction ...
Arianna Quintavalla +2 more
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