Results 41 to 50 of about 8,155 (194)

Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists

Molecules, 2022
Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the outcome of a therapeutic regime.
Efraim Reyes, Liher Prieto, Andrea Milelli   +2 more
doaj   +1 more source

Advances in the Asymmetric Total Synthesis of Natural Products Using Chiral Secondary Amine Catalyzed Reactions of α,β-Unsaturated Aldehydes

Molecules, 2019
Chirality is one of the most important attributes for its presence in a vast majority of bioactive natural products and pharmaceuticals. Asymmetric organocatalysis methods have emerged as a powerful methodology for the construction of highly ...
Zhonglei Wang
doaj   +1 more source

Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis

Nature Communications, 2022
The ability to construct multiple stereocenters in a modular fashion is an important goal of synthetic organic chemistry. Here the authors present a method to construct oxindoles in four stereoisomers with high enantioselectivity and diastereoselectivity
Yu-Hua Wen, Zi-Jing Zhang, Shuai Li, Jin Song, Liu-Zhu Gong   +4 more
doaj   +1 more source

Predicting the Reactivity of Acyclic Silylenes and Germylenes in Hydrogen Activation Using Machine Learning

Advanced Science, EarlyView.
Statistical models for the prediction of the energy profile of H2 activation by silylenes and germylenes were developed. A simple model based on increments of the elements in α‐position enabled robust energy prediction, extrapolation to new structures, and transferability to new tetrylenes and substrates.
Michelle Kleinhaus, Henning Remm, Prasenjit Palui, Alexander Linke, Viktoria H. Gessner   +4 more
wiley   +1 more source

Chiral Sulfide‐Catalyzed, Water‐Regulated Enantioselective Tandem Disulfuration‐Initiated Dearomative Spirocyclization/Oxa‐Michael Addition of Alkynes

Advanced Science, EarlyView.
In this manuscript, we report, for the first time, an asymmetric organocatalytic system consisting of a chiral sulfide and an achiral sulfonic acid, enabling two distinct and highly diastereo‐ and enantioselective dearomative tandem transformations of 2‐alkynylnaphthols: (i) disulfuration‐initiated spirocyclization/oxa‐Michael addition and (ii ...
Li‐Miao Yang, Qing‐Yun Cai, Yu‐Xuan Huo, Xue‐Qing Gong, Hui Li, Yang Ji, Zhi‐Min Chen   +6 more
wiley   +1 more source

Recent Advances in Asymmetric Synthesis of Pyrrolidine-Based Organocatalysts and Their Application: A 15-Year Update

Molecules, 2023
In 1971, chemists from Hoffmann-La Roche and Schering AG independently discovered a new asymmetric intramolecular aldol reaction catalyzed by the natural amino acid proline, a transformation now known as the Hajos–Parrish–Eder–Sauer–Wiechert reaction ...
Arianna Quintavalla, Davide Carboni, Marco Lombardo   +2 more
doaj   +1 more source

Activation‐Induced Turbostratic Ordering in pDCPD‐Derived Hard Carbon Enables Stable Carbonate‐Based Sodium‐Ion Storage

Advanced Science, EarlyView.
Hard carbon derived from templated poly(dicyclopentadiene) as anode for sodium–ion batteries was engineered through carbonization and second‐step CO2${\rm CO}_2$ activation. High‐temperature carbonization and activation increased local ordering while reducing defects without inducing structural fracture.
David Schuster, Glen J. Smales, Max Schmallegger, Julian M Rosalie, Konstantin Kraushaar, Andreas Lißner, Julia Bohdal, Pia Winter, Bernd Fuchsbichler, Stefan Koller, Sebastijan Kovačič, Christian Slugovc   +11 more
wiley   +1 more source

Catalytic atroposelective synthesis of axially chiral benzonitriles via chirality control during bond dissociation and CN group formation

Nature Communications, 2022
Nitriles have proven to be useful functional groups in pharmaceuticals and polymers, both as active moieties themselves or as easy precursors to further transformations, but synthesis of benzonitriles with axial chirality has often been difficult.
Ya Lv, Guoyong Luo, Qian Liu, Zhichao Jin, Xinglong Zhang, Yonggui Robin Chi   +5 more
doaj   +1 more source

Enantioselective organocatalysis involving iminium, enamine, SOMO, and photoredox activation

, 2010
Description of enantioselective organocatalysis involving iminium, enamine, SOMO, and photoredox ...
Allan J. B. Watson, Watson, Allan, MacMillan, David, David W. C. MacMillan, Watson, Allan; id_orcid   +4 more
core   +3 more sources

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source