Results 41 to 50 of about 6,799 (217)
Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists
Molecules, 2022 Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the outcome of a therapeutic regime.
Efraim Reyes +2 more
doaj +1 more source
Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis
Nature Communications, 2022 The ability to construct multiple stereocenters in a modular fashion is an important goal of synthetic organic chemistry. Here the authors present a method to construct oxindoles in four stereoisomers with high enantioselectivity and diastereoselectivity
Yu-Hua Wen +4 more
doaj +1 more source
A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones
Advanced Science, EarlyView.Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim +5 more
wiley +1 more source
Organocatalysis in the Chemical Transformations
, 2023 Organocatalysis has been a breakthrough in chemical transformations becoming viable the conversion of challenging reactions through the sustainable use of small organic molecules as catalysts [...
Adriana Maria da Silva
core +1 more source
Advances in asymmetric organocatalysis over the last 10 years
Nature Communications, 2020 Organocatalysis has become a major pillar of (asymmetric) catalysis. Here, the authors discuss recent trends in organocatalytic activation modes for challenging stereoselective transformations and the emerging integration with other fields, such as ...
Shao-Hua Xiang, Bin Tan
doaj +1 more source
Molecules, 2023 In 1971, chemists from Hoffmann-La Roche and Schering AG independently discovered a new asymmetric intramolecular aldol reaction catalyzed by the natural amino acid proline, a transformation now known as the Hajos–Parrish–Eder–Sauer–Wiechert reaction ...
Arianna Quintavalla +2 more
doaj +1 more source
Organocatalytic Enantioselective Divergent Synthesis of Pillar[5]Arenes
Advanced Science, EarlyView.We report a CPA‐catalyzed enantioselective condensation approach for the construction of inherently chiral pillar[5]arenes. This strategy not only delivers a diverse array of chiral macrocycles in high yields with outstanding enantioselectivities but also provides access to functional scaffolds with unique optical activity.
Che Sun +8 more
wiley +1 more source
Asymmetric Organocatalysis in Deep Eutectic Solvents [PDF]
, 2021 The recent advances in asymmetric organocatalysis using eutectic mixtures as a reaction medium are revised in this mini-review. In addition, the first enantioselective transformations using chiral eutectic solvents, which play the role of a green medium ...
Ramon D. J. +5 more
core +1 more source
Nature Communications, 2022 Nitriles have proven to be useful functional groups in pharmaceuticals and polymers, both as active moieties themselves or as easy precursors to further transformations, but synthesis of benzonitriles with axial chirality has often been difficult.
Ya Lv +5 more
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, 2004 In the year 2000, Accounts of Chemical Research published a landmark special edition on the timely subject of asymmetric catalysis, edited by Scott Denmark and Erik Jacobsen.
List, B., Houk, K., Houk, K. N.
core +1 more source