Results 241 to 250 of about 114,312 (393)

Tumor organoids may be more suitable for clinical personalized chemotherapeutic drug screening in lung adenocarcinoma. [PDF]

Front Cell Dev Biol
Yun W, Li Y, Ge Y, Zhang X, Liu H, Chen W, Xiao L.   +6 more
europepmc   +1 more source

Vps35∆/∆ organoids show a growth defect but are competent to respond to Wnt signaling.

, 2013
E. A. de Groot Reinoud, F. Farin Henner, Macůrková Marie, H. van Es Johan, Clevers Hans, C. Korswagen Hendrik   +5 more
openalex   +1 more source

XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer

Advanced Science, EarlyView.
Elevated spliced form of X‐box–binding protein 1 (XBP1) correlates with unfavorable responses to endocrine therapy plus CDK4/6 inhibitors in HR+/HER2− advanced breast cancer. XBP1s facilitates cell proliferation and G1/S transition by transcriptionally activating SND1, thereby activating the E2F1 pathway.
Yuting Sang, Shiyang Liu, Xujie Zhou, Weiru Chi, Min Xiong, Ming Chen, Hengyu Ren, Douwaner Liu, Liyi Zhang, Jingyan Xue, Yayun Chi, Jiong Wu   +11 more
wiley   +1 more source

Intestinal organoid cocultures with microbes

Nature Protocols, 2021
Jens Puschhof, Cayetano Pleguezuelos-Manzano, A. Martínez-Silgado, Ninouk Akkerman, Aurelia Saftien, Charelle Boot, Amy M. de Waal, J. Beumer, Devanjali Dutta, Inha Heo, H. Clevers   +10 more
semanticscholar   +1 more source

Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid culture. [PDF]

Sci Rep
Giles R, Meijer EM, Maas RGC, van Dijk CGM, Verhaar MC, Cheng C.   +5 more
europepmc   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Invasin-functionalized PIC hydrogels enable long-term 3D culture of epithelial organoids. [PDF]

Proc Natl Acad Sci U S A
Wijnakker JJAPM, Lim S, Schreurs R, Faria JF, Korving J, Begthel H, Iyer KK, Kouwer PHJ, Clevers H.   +8 more
europepmc   +1 more source

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

, 2014
Dong Gao, Ian Vela, Andrea Sboner, Phillip J. Iaquinta, Wouter R. Karthaus, Anuradha Gopalan, Catherine Dowling, Jackline Wanjala, Eva A. Undvall, Vivek Arora, John Wongvipat, Myriam Kossaï, Sinan Ramazanoglu, Luendreo P. Barboza, Wei Di, Zhen Cao, Qi Fan Zhang, Inna Sirota, Leili Ran, Theresa Y. MacDonald, Himisha Beltran, Juan‐Miguel Mosquera, Karim Touijer, Peter T. Scardino, Vincent P. Laudone, Kristen Curtis, Dana E. Rathkopf, Michael J. Morris, Daniel C. Danila, Susan F. Slovin, Stephen B. Solomon, James A. Eastham, Ping Chi, Brett S. Carver, Mark A. Rubin, Howard I. Scher, Hans Clevers, Charles L. Sawyers, Yu Chen   +38 more
openalex   +1 more source

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms. [PDF]

Bioact Mater
Zhang C, Shen Y, Huang M, Wang G, Miao Q, Shi H, Gao R, Wang K, Luo M.   +8 more
europepmc   +1 more source