Results 241 to 250 of about 90,274 (350)

Discovery ofPotent and Selective Pyrrolo[2,3‑d]Pyrimidine-BasedAurora A Inhibitors with DemonstratedEfficacy against Patient-Derived Gastric Cancer Organoids

Rong Zhang (44942), Tao Yu (176965), Manzhan Zhang (22246361), Jiatong Li (5910524), Ao Gu (22246364), Muerzhate Aimaiti (22246367), Shiliang Li (298790), Huan He (548057), Yingbin Liu (197365), Honglin Li (19441)   +9 more
openalex   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Time evolution of the organoid growth process.

Sakurako Tanida (22076056), Kana Fuji (22076059), Linjie Lu (7180379), Tristan Guyomar (22076062), Byung Ho Lee (2685499), Alf Honigmann (1661323), Anne Grapin-Botton (186660), Daniel Riveline (371781), Tetsuya Hiraiwa (9192386), Makiko Nonomura (325442), Masaki Sano (269338)   +10 more
openalex   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Single molecule nanopore counting assay targeting small extracellular vesicle cargo for non-invasive monitoring of cerebral organoid development and health. [PDF]

Sci Rep
Saiduzzaman SM, Xu R, Sampad MJN, Hoffman RN, Seiler ST, Brail Q, Yurevych V, Walker ZJ, Wells TN, Ong EM, Yuzvinsky TD, Hawkins AR, Salama SR, Teodorescu M, Haussler D, Schmidt H.   +15 more
europepmc   +1 more source

Generation of patient-derived organoids.

Wei Ni Yew (22439334), Christopher James Dean (22439337), Dedrick Kok Hong Chan (22439340)   +2 more
openalex   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Advances in three-dimensional modeling of ischemic injury. [PDF]

J Cereb Blood Flow Metab
Halkoluoto A, Dhungana H, Keuters MH.
europepmc   +1 more source

Beyond the tooth: Cross-talk between oral and gut/brain organoids

Long Bai, Jiacan Su
openalex   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source