Results 31 to 40 of about 114,312 (393)
Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]
, 2021 ABSTRACTOver the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling +6 more
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Recent advances in lung organoid development and applications in disease modeling
Journal of Clinical Investigation, 2023 Over the last decade, several organoid models have evolved to acquire increasing cellular, structural, and functional complexity. Advanced lung organoid platforms derived from various sources, including adult, fetal, and induced pluripotent stem cells ...
A. Vazquez-Armendariz, P. R. Tata
semanticscholar +1 more source
Whole Organ Engineering: Approaches, Challenges, and Future Directions
Applied Sciences, 2020 End-stage organ failure remains a leading cause of morbidity and mortality across the globe. The only curative treatment option currently available for patients diagnosed with end-stage organ failure is organ transplantation.
Sogu Sohn +4 more
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Fundamental signaling pathways for glioblastoma drug resistance and developing robust organoid models for drug discovery [PDF]
Organoid, 2022 This article presents a review of the current literature on the molecular mechanisms of treatment resistance in glioblastoma. As mounting research continues to explore novel methods of treating glioblastoma, from using organoid models for drug screening ...
Athira Pratap +3 more
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Organoids in Translational Oncology [PDF]
Journal of Clinical Medicine, 2020 Translational medicine aims to translate the most promising preclinical research into clinical practice. Oncology is a continuously growing medical field: the scientific research on cancer biology is currently based on in vitro experiments, carried out on tissue culture plates (TCPs) and other 2D samples.
Benedetta Marrelli +9 more
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Towards a better understanding of diabetes mellitus using organoid models
Nature Reviews Endocrinology, 2023 Pancreas and islet organoids enable the study of monogenic forms of diabetes mellitus, notably neonatal diabetes mellitus. For type 1 diabetes mellitus, platforms mixing patient-relevant islets and immune cells are expanding. Organoid models are emerging
Belin Selcen Beydag-Tasöz +2 more
semanticscholar +1 more source
Three-dimensional cardiac organoid formation accelerates the functional maturation of human induced pluripotent stem cell-derived cardiomyocytes [PDF]
Organoid, 2022 Background Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) offer a promising source for heart disease modeling and drug screening.
Hanbyeol Lee +7 more
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Standardization of organoid culture in cancer research
Cancer Medicine, 2023 Establishing a valid in vitro model to represent tumor heterogeneity and biology is critical but challenging. Tumor organoids are self‐assembled three‐dimensional cell clusters which are of great significance for recapitulating the histopathological ...
Changchun Zhou +10 more
semanticscholar +1 more source
Molecular Autism, 2020 The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds of genes, converging at the functional level on selective biological domains such as epigenetic ...
Cristina Cheroni +2 more
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Understanding the cellular pathogenesis of COVID-19 symptoms using organoid technology [PDF]
Organoid, 2022 Patients with coronavirus disease 2019 (COVID-19), which has recently caused a pandemic, have reported symptoms of coronavirus infection that are not well understood by the medical community in general. After severe acute respiratory syndrome coronavirus
Young Hyun Che, Yong Jun Kim
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