Towards organoid culture without Matrigel
Communications Biology, 2021 Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ function in miniature—are of growing interest in developmental biology and medicine.
M. Kozlowski, C. Crook, H. Ku
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Recent advances in multicellular human liver models [PDF]
Organoid, 2022 The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug ...
Seon Ju Mun +5 more
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Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation [PDF]
, 2017 RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs).
Arora, Vivek K +7 more
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Engineered adipose tissue platforms: recent breakthroughs and future perspectives [PDF]
Organoid, 2023 As overweight and obesity rates have increased worldwide, the prevalence of metabolic disorders has also grown. Due to the lack of physiologically relevant adipose tissue platforms, research in adipose tissue biology has relied on animal models, leading ...
Heejeong Yoon, Tae-Eun Park
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Tumor organoid biobank-new platform for medical research
Scientific Reports, 2023 Organoids are a new type of 3D model for tumor research, which makes up for the shortcomings of cell lines and xenograft models, and promotes the development of personalized precision medicine.
Xuexue Xie, Xin-yu Li, Wei Song
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Induced pluripotent stem cell-derived hematopoietic stem and progenitor cells: potential, challenges, and future perspectives [PDF]
Organoid, 2023 Hematopoietic stem and progenitor cells (HSPCs) are responsible for the lifetime dynamics of hematopoiesis, as they are well known for their self-renewing ability and multipotency to differentiate into all types of blood cells, including both myeloid and
Myoung Hee Han +2 more
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One-step achievement of tumor spheroid-induced angiogenesis in a high-throughput microfluidic platform: one-step tumor angiogenesis platform [PDF]
Organoid, 2023 Research on the development of anti-cancer drugs has progressed, but the low reliability of animal experiments due to biological differences between animals and humans causes failures in the clinical process.
Seonghyuk Park +6 more
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A 3-D in vitro co-culture model of mammary gland involution. [PDF]
, 2014 Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru +5 more
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Genetic engineering in organoids [PDF]
Journal of Molecular Medicine, 2021 AbstractThree-dimensional organoids have been widely used for developmental and disease modeling. Organoids are derived from both adult and pluripotent stem cells. Various types are available for mimicking almost all major organs and tissues in the mouse and human.
Isaree Teriyapirom +2 more
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Microengineered organoids: reconstituting organ-level functions in vitro [PDF]
Organoid, 2023 In vitro miniaturized organoids are innovative tools with varying applications in biomedical engineering, such as drug testing, disease modeling, organ development studies, and regenerative medicine. However, conventional organoid development has several
Sunho Park +6 more
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