Results 1 to 10 of about 60,030 (219)

Organoid Models and Next-Generation Sequencing for Bone Marrow and Related Disorders

Organoids, 2023
Challenges to the musculoskeletal system negatively impact the quality of life of people suffering from them, leading to pain, a decline in mobility, genetic alterations, and potential disorders.
Magdalena Rausch, Neelam Iqbal, Shelly Pathak, Heather E. Owston, Payal Ganguly   +4 more
doaj   +1 more source

Contraindicated Drug Responses in Dravet Syndrome Brain Organoids Utilizing Micro Electrode Array Assessment Methods

Organoids, 2023
Ensuring drug safety for patients with specific neurological disorders is of paramount importance. For instance, certain antiepileptic drugs (AEDs) are contraindicated in Dravet Syndrome (DS), which is characterized by a deficiency in Na+ channel ...
Remi Yokoi, Nami Nagafuku, Yuto Ishibashi, Naoki Matsuda, Ikuro Suzuki   +4 more
doaj   +1 more source

The Rapid Generation of Cell-Laden, FACS-Compatible Collagen Gels

Organoids, 2023
A three-dimensional cell culture in hydrogel beads can support cell growth and differentiation into multi-cellular structures, and these gel beads could be used as building blocks for more complex three-dimensional assemblies.
Yi Xiao, Qiaoling Huang, Jesse W. Collins, Julie Brouchon, Jeffery A. Nelson, Zachary Niziolek, Alison O’Neil, Fangfu Ye, David A. Weitz, John A. Heyman   +9 more
doaj   +1 more source

A Microwell Device for the Efficient Generation of Arrays of Microtissues and Humanized Bone Marrow Micro-Ossicles

Organoids, 2023
(1) Background: There are no high-throughput microtissue platforms for generating bone marrow micro-ossicles. Herein, we describe a method for the assembly of arrays of microtissues from bone marrow stromal cells (BMSC) in vitro and their maturation into
Kathryn Futrega, Md. Shafiullah Shajib, Pamela G. Robey, Michael R. Doran   +3 more
doaj   +1 more source

Development of Matrix-Embedded Bovine Tracheal Organoids to Study the Innate Immune Response against Bovine Respiratory Disease

Organoids, 2023
Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle. Bovine herpesvirus-1 (BHV-1) is one of the main culprits of BRD; however, research on BHV-1 is hampered by the lack of suitable models for infection and ...
Pin Shie Quah, Bang M. Tran, Vincent D.A. Corbin, Jessie J.-Y. Chang, Chinn Yi Wong, Andrés Diaz-Méndez, Carol A. Hartley, Weiguang Zeng, Eric Hanssen, Zlatan Trifunovic, Patrick C. Reading, David C. Jackson, Elizabeth Vincan, Lachlan J.M. Coin, Georgia Deliyannis   +14 more
doaj   +1 more source

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

EMBO Molecular Medicine, 2022
Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive.
Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo   +13 more
doaj   +1 more source

Applications for Colon Organoid Models in Cancer Research

Organoids, 2023
Organoids are 3D organ-like structures grown from stem cells in vitro that mimic the organ or disease from which they are derived. Due to their stem cell origin, organoids contain a heterogeneous population of cells reflecting the diversity of cell types
Matthew J. Munro, Swee T. Tan, Clint Gray   +2 more
doaj   +1 more source

The Next Generation of Organoids Will Be More Complex and Even Closer to Resembling Real Organs: An Interview with Prof. Dr. Hans Clevers

Organoids
In this issue, we are pleased and honored to have an interview with Professor Hans Clevers, who is the Advisory Board Member of Organoids [...]
Süleyman Ergün, Organoids Editorial Office   +1 more
doaj   +1 more source

Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1

Frontiers in Veterinary Science
IntroductionCurrent management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity.
Mengjuan Chen, Mengjuan Chen, Hui Han, Hui Han, Mengke Qin, Mengke Qin, Huixin Li, Huixin Li, Qiqi Lu, Qiqi Lu, Xin Huang, Xin Huang, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +15 more
doaj   +1 more source

Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Journal of Experimental & Clinical Cancer Research
Background The inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival. Response testing on patient-derived organoids (PDOs) is a promising biomarker for treatment efficacy ...
Lidwien P. Smabers, Emerens Wensink, Carla S. Verissimo, Esmee Koedoot, Katerina-Chara Pitsa, Maarten A. Huismans, Celia Higuera Barón, Mayke Doorn, Liselot B. Valkenburg-van Iersel, Geert A. Cirkel, Anneta Brousali, René Overmeer, Miriam Koopman, Manon N. Braat, Bas Penning de Vries, Sjoerd G. Elias, Robert G. Vries, Onno Kranenburg, Sylvia F. Boj, Jeanine M. Roodhart   +19 more
doaj   +1 more source