Results 11 to 20 of about 60,030 (219)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Preparation and functional validation of rabbit anti-canine CD3ε monoclonal antibody

Frontiers in Veterinary Science
IntroductionCD3, a surface antigen critical for T cell activation and signal transduction, serves as a key diagnostic marker for T cell-associated malignancies and a therapeutic target in immunotherapy.
Huixin Li, Huixin Li, Mengjuan Chen, Mengjuan Chen, Rongmiao Yue, Rongmiao Yue, Sihao Li, Bowen Shi, Mengke Qin, Mengke Qin, Qingda Meng, Qingda Meng, Shanshan Xie, Shanshan Xie   +13 more
doaj   +1 more source

SMAD1 Is Dispensable for CDX2 Induction but Required for the Repression of Ectopic Small-Intestinal Gene Expression in Human-Pluripotent-Stem-Cell-Derived Colonic Organoids

Organoids, 2023
The generation of gastrointestinal tissues from human pluripotent stem cells has provided unprecedented insight into the molecular mechanisms that drive the patterning of the primitive gut tube.
Na Qu, Abdelkader Daoud, Braxton Jeffcoat, Jorge O. Múnera   +3 more
doaj   +1 more source

Vascularizing Organoids to Promote Long-Term Organogenesis on a Chip

Organoids, 2023
Organoids have emerged as a powerful tool for studying organ development, disease modeling, and drug discovery due to their ability to mimic the in vivo structure and function of organs in a three-dimensional in vitro model.
Xinhui Wang, Brent M. Bijonowski, Nicholas A. Kurniawan   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Development of Low-Cost CNC-Milled PMMA Microfluidic Chips as a Prototype for Organ-on-a-Chip and Neurospheroid Applications

Organoids
Improved in vitro models are needed to reduce costs and delays in central nervous system (CNS) drug discovery. The FDA Modernization Acts 2.0 and 3.0 require human-centered alternative testing methods to mitigate animal-based experiments and discovery ...
Sushmita Mishra, Ginia Mondal, Murali Kumarasamy   +2 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Circulating Tumor Cell‐Derived Organoids: Current Progress, Applications, and Future

MedComm – Future Medicine
Circulating tumor cells (CTCs) are malignant cells that detach from primary or metastatic tumors and enter the bloodstream. Organoids, as three‐dimensional in vitro models, can mimic the tumor microenvironment and histopathological characteristics ...
Tiantian Li, Biao Deng, Sheng Li, Yanxia Wu, Zhenghao Lu, Zhu Liang   +5 more
doaj   +1 more source

Organoid Models of Lymphoid Tissues

Organoids
Lymphoid organs are critical for organizing the development of the immune system, generating immune tolerance, and orchestrating the adaptive immune response to foreign antigens.
Ania Bogoslowski, Joice Ren, Clément Quintard, Josef M. Penninger   +3 more
doaj   +1 more source

Human Brain Organoids and Consciousness: Moral Claims and Epistemic Uncertainty

Organoids, 2023
Human brain organoids provide a remarkable opportunity to model prenatal human brain biology in vitro by recapitulating features of in utero molecular, cellular and systems biology. An ethical concern peculiar to human brain organoids is whether they are
Eliza Goddard, Eva Tomaskovic-Crook, Jeremy Micah Crook, Susan Dodds   +3 more
doaj   +1 more source