Results 11 to 20 of about 120,310 (351)

Organoid Models and Next-Generation Sequencing for Bone Marrow and Related Disorders

Organoids, 2023
Challenges to the musculoskeletal system negatively impact the quality of life of people suffering from them, leading to pain, a decline in mobility, genetic alterations, and potential disorders.
Magdalena Rausch, Neelam Iqbal, Shelly Pathak, Heather E. Owston, Payal Ganguly   +4 more
doaj   +1 more source

Contraindicated Drug Responses in Dravet Syndrome Brain Organoids Utilizing Micro Electrode Array Assessment Methods

Organoids, 2023
Ensuring drug safety for patients with specific neurological disorders is of paramount importance. For instance, certain antiepileptic drugs (AEDs) are contraindicated in Dravet Syndrome (DS), which is characterized by a deficiency in Na+ channel ...
Remi Yokoi, Nami Nagafuku, Yuto Ishibashi, Naoki Matsuda, Ikuro Suzuki   +4 more
doaj   +1 more source

The Rapid Generation of Cell-Laden, FACS-Compatible Collagen Gels

Organoids, 2023
A three-dimensional cell culture in hydrogel beads can support cell growth and differentiation into multi-cellular structures, and these gel beads could be used as building blocks for more complex three-dimensional assemblies.
Yi Xiao, Qiaoling Huang, Jesse W. Collins, Julie Brouchon, Jeffery A. Nelson, Zachary Niziolek, Alison O’Neil, Fangfu Ye, David A. Weitz, John A. Heyman   +9 more
doaj   +1 more source

Single organoid RNA-sequencing reveals high organoid-to-organoid variability [PDF]

, 2021
ABSTRACTOver the last decades, organoids have been established from the majority of tissue resident stem and iPS cells. They hold great promise for our understanding of mammalian organ development, but also for the study of disease or even personalized medicine.
Kristin Gehling, Swati Parekh, Farina Schneider, Marcel Kirchner, Vangelis Kondylis, Chrysa Nikopoulou, Peter Tessarz   +6 more
openaire   +1 more source

A Microwell Device for the Efficient Generation of Arrays of Microtissues and Humanized Bone Marrow Micro-Ossicles

Organoids, 2023
(1) Background: There are no high-throughput microtissue platforms for generating bone marrow micro-ossicles. Herein, we describe a method for the assembly of arrays of microtissues from bone marrow stromal cells (BMSC) in vitro and their maturation into
Kathryn Futrega, Md. Shafiullah Shajib, Pamela G. Robey, Michael R. Doran   +3 more
doaj   +1 more source

Development of Matrix-Embedded Bovine Tracheal Organoids to Study the Innate Immune Response against Bovine Respiratory Disease

Organoids, 2023
Bovine respiratory disease (BRD) is the leading cause of morbidity and mortality in feedlot cattle. Bovine herpesvirus-1 (BHV-1) is one of the main culprits of BRD; however, research on BHV-1 is hampered by the lack of suitable models for infection and ...
Pin Shie Quah, Bang M. Tran, Vincent D.A. Corbin, Jessie J.-Y. Chang, Chinn Yi Wong, Andrés Diaz-Méndez, Carol A. Hartley, Weiguang Zeng, Eric Hanssen, Zlatan Trifunovic, Patrick C. Reading, David C. Jackson, Elizabeth Vincan, Lachlan J.M. Coin, Georgia Deliyannis   +14 more
doaj   +1 more source

[Lung organoids].

Medecine sciences : M/S, 2020
As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions ...
Bourguignon, Chloé, Vernisse, Charlotte, Mianné, Joffrey, Fieldes, Mathieu, Ahmed, Engi, Petit, Aurélie, Vachier, Isabelle, Bertrand, Thierry Lavabre, Assou, Said, Bourdin, Arnaud, de Vos, John   +10 more
openaire   +3 more sources

Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]

, 2020
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois, Glickman, Randolph D, Nasonkin, Igor O, Petersen-Jones, Simon M, Seiler, Magdalene, Singh, Ratnesh K, Winkler, Paige   +6 more
core   +1 more source

SMAD1 Is Dispensable for CDX2 Induction but Required for the Repression of Ectopic Small-Intestinal Gene Expression in Human-Pluripotent-Stem-Cell-Derived Colonic Organoids

Organoids, 2023
The generation of gastrointestinal tissues from human pluripotent stem cells has provided unprecedented insight into the molecular mechanisms that drive the patterning of the primitive gut tube.
Na Qu, Abdelkader Daoud, Braxton Jeffcoat, Jorge O. Múnera   +3 more
doaj   +1 more source

Vascularizing Organoids to Promote Long-Term Organogenesis on a Chip

Organoids, 2023
Organoids have emerged as a powerful tool for studying organ development, disease modeling, and drug discovery due to their ability to mimic the in vivo structure and function of organs in a three-dimensional in vitro model.
Xinhui Wang, Brent M. Bijonowski, Nicholas A. Kurniawan   +2 more
doaj   +1 more source