Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation [PDF]
, 2017 RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs).
Arora, Vivek K +7 more
core +2 more sources
Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
core +1 more source
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease
EMBO Molecular Medicine, 2022 Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive.
Chunyue Liu +13 more
doaj +1 more source
Human Brain Organoids and Consciousness: Moral Claims and Epistemic Uncertainty
Organoids, 2023 Human brain organoids provide a remarkable opportunity to model prenatal human brain biology in vitro by recapitulating features of in utero molecular, cellular and systems biology. An ethical concern peculiar to human brain organoids is whether they are
Eliza Goddard +3 more
doaj +1 more source
Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]
, 2013 Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa +12 more
core +4 more sources
A 3-D in vitro co-culture model of mammary gland involution. [PDF]
, 2014 Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru +5 more
core +3 more sources
Bioengineering, 2023 Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature
Hannah A. Strobel +2 more
openaire +3 more sources
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
core +2 more sources
Cornea organoids from human induced pluripotent stem cells. [PDF]
, 2017 The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M +5 more
core +3 more sources
Organoid assessment technologies
Clinical and Translational Medicine, 2023 AbstractDespite enormous advances in the generation of organoids, robust and stable protocols of organoids are still a major challenge to researchers. Research for assessing structures of organoids and the evaluations of their functions on in vitro or in vivo is often limited by precision strategies. A growing interest in assessing organoids has arisen,
Yuyuan Gu +5 more
openaire +3 more sources