Results 31 to 40 of about 112,967 (355)
A 3-D in vitro co-culture model of mammary gland involution. [PDF]
, 2014 Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring.
Botos, Laur-Alexandru +5 more
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A brief history of organoids [PDF]
American Journal of Physiology-Cell Physiology, 2020 In vitro cell cultures are crucial research tools for modeling human development and diseases. Although the conventional monolayer cell cultures have been widely used in the past, the lack of tissue architecture and complexity of such model fails to inform the true biological processes in vivo.
Claudia Corrò +2 more
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Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease
EMBO Molecular Medicine, 2022 Aberrant localization of proteins to mitochondria disturbs mitochondrial function and contributes to the pathogenesis of Huntington’s disease (HD). However, the crucial factors and the molecular mechanisms remain elusive.
Chunyue Liu +13 more
doaj +1 more source
Bioengineering, 2023 Tissue organoids hold enormous potential as tools for a variety of applications, including disease modeling and drug screening. To effectively mimic the native tissue environment, it is critical to integrate a microvasculature with the parenchyma and stroma. In addition to providing a means to physiologically perfuse the organoids, the microvasculature
Hannah A. Strobel +2 more
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Science, 2019 Organoids are multicellular structures that can be derived from adult organs or pluripotent stem cells. Early versions of organoids range from simple epithelial structures to complex, disorganized tissues with large cellular diversity. The current challenge is to engineer cellular complexity into organoids in a controlled manner that results in ...
Takanori Takebe, James M. Wells
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Engineering Organoid Vascularization [PDF]
Frontiers in Bioengineering and Biotechnology, 2019 The development of increasingly biomimetic human tissue analogs has been a long-standing goal in two important biomedical applications: drug discovery and regenerative medicine. In seeking to understand the safety and effectiveness of newly developed pharmacological therapies and replacement tissues for severely injured non-regenerating tissues and ...
Grebenyuk, Sergei, Ranga, Adrian
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Metabolism of parathyroid organoids
Frontiers in Endocrinology, 2023 IntroductionWe successfully developed a broad spectrum of patient-derived endocrine organoids (PDO) from benign and malignant neoplasms of thyroid, parathyroid, and adrenal glands. In this study, we employed functionally intact parathyroid PDOs from benign parathyroid tissues to study primary hyperparathyroidism (PHPT), a common endocrine metabolic ...
Konjeti R. Sekhar +7 more
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Organoids, 2023 We evaluated the redox status, precisely glutathione levels, which have a major impact in cellular detoxification and antioxidant defence in IBD-derived and healthy intestinal organoids.
Georg Csukovich +4 more
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Incorporating Immune Cells into Organoid Models: Essential for Studying Human Disease
Organoids, 2023 Organoid-based research has made significant discoveries and contributions to our understanding of human organ function in both health and disease. To continue making progress, it is crucial to acknowledge the crucial role of the immune system in all ...
Ania Bogoslowski +2 more
doaj +1 more source
Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. [PDF]
, 2018 Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration.
Cai, Tao +11 more
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