Results 51 to 60 of about 120,310 (351)

Development of Low-Cost CNC-Milled PMMA Microfluidic Chips as a Prototype for Organ-on-a-Chip and Neurospheroid Applications

Organoids
Improved in vitro models are needed to reduce costs and delays in central nervous system (CNS) drug discovery. The FDA Modernization Acts 2.0 and 3.0 require human-centered alternative testing methods to mitigate animal-based experiments and discovery ...
Sushmita Mishra, Ginia Mondal, Murali Kumarasamy   +2 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Organoid Models of Lymphoid Tissues

Organoids
Lymphoid organs are critical for organizing the development of the immune system, generating immune tolerance, and orchestrating the adaptive immune response to foreign antigens.
Ania Bogoslowski, Joice Ren, Clément Quintard, Josef M. Penninger   +3 more
doaj   +1 more source

Applications for Colon Organoid Models in Cancer Research

Organoids, 2023
Organoids are 3D organ-like structures grown from stem cells in vitro that mimic the organ or disease from which they are derived. Due to their stem cell origin, organoids contain a heterogeneous population of cells reflecting the diversity of cell types
Matthew J. Munro, Swee T. Tan, Clint Gray   +2 more
doaj   +1 more source

Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine [PDF]

, 2017
Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin
Aladegbami, Bola, Bao, James, Barron, Lauren, Colasanti, Jason, Erwin, Christopher R, Guo, Jun, Warner, Brad W   +6 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Circulating Tumor Cell‐Derived Organoids: Current Progress, Applications, and Future

MedComm – Future Medicine
Circulating tumor cells (CTCs) are malignant cells that detach from primary or metastatic tumors and enter the bloodstream. Organoids, as three‐dimensional in vitro models, can mimic the tumor microenvironment and histopathological characteristics ...
Tiantian Li, Biao Deng, Sheng Li, Yanxia Wu, Zhenghao Lu, Zhu Liang   +5 more
doaj   +1 more source

Trophoblast Organoids: Capturing the Complexity of Early Placental Development In Vitro

Organoids
First trimester placental development comprises some of the most critical yet understudied events that impact fetal development. Improper placentation leads to a host of health issues that not only impact the fetal period but also influence offspring ...
Brady M. Wessel, Jenna N. Castro, Victoria H. J. Roberts   +2 more
doaj   +1 more source

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. [PDF]

, 2014
Intestinal crypt fission is a homeostatic phenomenon, observable in healthy adult mucosa, but which also plays a pathological role as the main mode of growth of some intestinal polyps.
A. Patrick Gunning, Aimee Parker, Andreu, Arber, Barker, Barker, Bashir, Berlanga-Acosta, Buczacki, Buske, Buske, Cairnie, Carmen Pin, Cheng, Cheng, Clarke, Clevers, Cummins, Cummins, Dehmer, Dekaney, Drasdo, Drasdo, Dunn, Durand, Edwards, Fauser, Galle, Hannezo, Haramis, Hirata, Humphries, Humphries, Hutter, Ian T. Johnson, Leushacke, Li, Li, Loeffler, Loeffler, Loeffler, Loeffler, Meineke, Milicic, Miyoshi, Nelson, Nelson, Ootani, Osborne, Pin, Pitt-Francis, Potten, Roth, Rothenberg, Sato, Sato, Sato, Sato, Simon R. Carding, Snippert, St Clair, Toshiro Sato, Totafurno, van Es, Wasan, Wong, Wright, Wright, Wright, Yuki Ohta   +69 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source