Results 71 to 80 of about 7,059 (201)

Evaluation of Acephate Metabolites Generated by Zebrafish (Danio rerio) Using LC–HRMS and Metabolomics Approach

Journal of Applied Toxicology, Volume 46, Issue 5, Page 1679-1686, May 2026.
ABSTRACT Acephate is an organophosphate insecticide widely used. This pesticide can be metabolized into methamidophos, a molecule highly toxic. Both have demonstrated the ability to promote serious toxic effects on nontarget organisms and have been identified in surface waters around the world. Therefore, it is important to understand their behavior in
Mariana Laiz Silva de Lima, Lucas Rodrigues Cunha, Karina Taciana Santos Rubio, Maria Elvira Poleti Martucci   +3 more
wiley   +1 more source

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model [PDF]

, 2010
Background: Due to the use of organophosphates (OP) as pesticides and the availability of OP-type nerve agents, an effective medical treatment for OP poisonings is still a challenging problem.
Wagner, Sylvia, Kufleitner, Jürgen, Zensi, Anja, Dadparvar, Miriam, Wien, Sascha, Bungert, Judith, Vogel, Tikva, Worek, Franz, Kreuter, Jörg (Prof. Dr.), Briesen, Hagen von   +9 more
core   +2 more sources

Using deep learning to assess the toxicological effects of sublethal exposure of a novel green pesticide in a stored‐product beetle

Pest Management Science, Volume 82, Issue 5, Page 4319-4331, May 2026.
This study employs an AI‐driven multidisciplinary approach to increase our understanding of the toxicological effects of sublethal concentrations of carlina oxide on Prostephanus truncatus. Sublethal exposure to the carlina oxide induced changes in motor patterns and thigmotaxis, highlighting its potential role in integrated pest management strategies.
Anita Casadei, Maria C. Boukouvala, Gianluca Manduca, Nickolas G. Kavallieratos, Filippo Maggi, Marta Ferrati, Eleonora Spinozzi, Cesare Stefanini, Antonio DeSimone, Donato Romano   +9 more
wiley   +1 more source

Neurological Disorders in Dogs: A Retrospective Analysis of Prevalence, Aetiology, Lesion Locations, and Regional Variations in Northeastern Iran

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This retrospective study evaluated 422 dogs with neurological disorders among 9131 canine referrals over 8.5 years in northeastern Iran. Infectious diseases, particularly canine distemper (33.2%), were the leading cause, followed by trauma and idiopathic conditions. The prosencephalon was the most frequently affected anatomical region.
Ali Behrouzian, Ali Asghar Sarchahi, Hadi Jabbari Noghabi   +2 more
wiley   +1 more source

Acute tetraparesis in a labrador retriever with suspected ectopic insulinoma and paraneoplastic polyneuropathy

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Summary This case report describes a 10‐year‐old, male, neutered labrador retriever that was presented with acute non‐ambulatory tetraparesis, later diagnosed with an ectopic insulinoma and paraneoplastic polyneuropathy. Clinical evaluation revealed severe hypoglycaemia, generalised neuromuscular signs and electromyography findings were consistent with
Laryssa Straub, Janet Kovak McClaran, Emma Laws, Ana Garcia Fernandez   +3 more
wiley   +1 more source

Blood-Brain Barrier Cellular Responses Toward Organophosphates: Natural Compensatory Processes and Exogenous Interventions to Rescue Barrier Properties

Frontiers in Cellular Neuroscience, 2018
Organophosphorus compounds (OPs) are highly toxic chemicals widely used as pesticides (e.g., paraoxon (PX)- the active metabolite of the insecticide parathion) and as chemical warfare nerve agents.
Orly Ravid, Shirin Elhaik Goldman, David Macheto, Yael Bresler, Raquel Ines De Oliveira, Sigal Liraz-Zaltsman, Fabien Gosselet, Lucie Dehouck, Michal Schnaider Beeri, Michal Schnaider Beeri, Michal Schnaider Beeri, Itzik Cooper, Itzik Cooper   +12 more
doaj   +1 more source

Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]

, 2017
Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
core  

Synaptic transmission as a cooperative phenomenon in confined systems [PDF]

, 2017
In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a synaptic ...
Chalyi, A. V., Vasilev, A. N., Zaitseva, E. V.   +2 more
core   +2 more sources

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Seizure and Status Epilepticus in Human Organophosphate Poisoning: A Narrative Review

Neurology International
Organophosphate (OP) exposure can trigger seizures within minutes and can rapidly evolve into status epilepticus (SE). Early seizure generation is plausibly driven by acetylcholinesterase inhibition, leading to central cholinergic overstimulation.
Giuseppe Magro, Oreste Marsico, Federico Tosto, Concetta Lobianco, Laura Rapisarda, Giovanni Mastroianni, Angelo Pascarella   +6 more
doaj   +1 more source