Results 81 to 90 of about 7,059 (201)

Rational Design and Directed Evolution of Human Paraoxonase I (huPON1) for Increased Solubility and Stability in E. coli [PDF]

, 2009
Paraoxonase I (PON1) is a serum hydrolase that has been found to hydrolyze organophosphates (OP), such as VX and sarin. Because human PON1 (huPON1) is a human protein with reasonable activity, it seems like a promising therapeutic agent against OP ...
Matic, George, Jr.
core  

Environmental Exposures and Parkinson's Disease. [PDF]

, 2016
Parkinson's disease (PD) affects millions around the world. The Braak hypothesis proposes that in PD a pathologic agent may penetrate the nervous system via the olfactory bulb, gut, or both and spreads throughout the nervous system. The agent is unknown,
Litvan, Irene, Nandipati, Sirisha
core   +2 more sources

Recent Development of Nanoparticle Platforms for Organophosphate Nerve Agent Detoxification

Langmuir
Poisoning by organophosphate (OP) nerve agents remains a pressing global threat due to their extensive use in chemical warfare agents and pesticides, potentially causing high morbidity and mortality worldwide. This urgent need for effective countermeasures has driven considerable interest in innovative detoxification approaches.
Kailin Feng, Jiayuan Alex Zhang, Wei-Ting Shen, Tianle Leng, Zhidong Zhou, Yiyan Yu, Weiwei Gao, Liangfang Zhang   +7 more
openaire   +4 more sources

Zebrafish models for human acute organophosphorus poisoning [PDF]

, 2015
Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war ...
Arick II, Mark, Arick II, Mark, Babin, Patrick J., Cachot, Jérôme, Escalon, B. Lynn, Faria, Melissa, Garcia-Reyero, Natàlia, Knoll-Gellida, Anja, Le Bihanic, Florane, Le Bihanic, Florane, Mathieu, Guilaine, Padrós, Francesc, Prats, Eva, Raldúa, Demetrio, Rial, Eduardo, Sebastián, David, Soares, Amadeu M. V. M., Zorzano, Antonio   +17 more
core   +4 more sources

The Impact of Chemical Toxicants and Air Pollutants on Neurodegenerative Disorders and Their Underlying Potential Mechanisms: A Literature Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Neurodegenerative disorders are marked by progressive deterioration of neurons, affecting cognitive, memory, and motor functions. This decline creates substantial personal and social challenges, making early identification of risk factors essential for effective intervention.
Sameeha Fatima Khan, Warda Rasool, Muhammad Hamza Khan, Ganesh Kumar, Azka Ijaz, Maryam Amjad, Mahin Qudeer Sheikh, Shree Rath, Digbijay Kunwar, Anum Akbar   +9 more
wiley   +1 more source

Pesticide prioritization based on risk and model diet proposals for assessing cumulative exposure to pesticide residues in the Brazilian population through food consumption

Pest Management Science, Volume 82, Issue 4, Page 3853-3873, April 2026.
A risk classification of registered pesticides in Brazil was conducted, and the contribution of food to cumulative pesticide exposure was evaluated. Model diets were proposed, based on Brazilian consumption patterns. Abstract BACKGROUND Pesticide residue exposure assessments can be carried out during both the pre‐regulation and post‐regulation phases ...
Bianca Figueiredo de Mendonça Pereira, Bernardete Ferraz Spisso   +1 more
wiley   +1 more source

Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication [PDF]

, 2014
Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality.
Blair, Robert E., Carter, Dawn S., DeLorenzo, Robert J., Deshpande, Laxmikant Sudhir, Phillips, Kristin   +4 more
core   +2 more sources

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, Volume 101, Issue 2, Page 580-601, April 2026.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source

Proinflammatory cytokines, oxidative stress, and organ function as biomarkers of soman (GD) chronic neurotoxicity

Scientific Reports
Organophosphate (OP) nerve agents, such as soman (GD), pose great risk to neurological health by inhibiting acetylcholinesterase, leading to seizures, epilepsy, and behavioral deficits.
Nyzil Massey, Suraj S. Vasanthi, Luis G. Gimenez-Lirola, Harm Tyler, Thimmasettappa Thippeswamy   +4 more
doaj   +1 more source

New views on physiological functions and regulation of butyrylcholinesterase and potential therapeutic interventions

Frontiers in Molecular Biosciences
Butyrylcholinesterase (BChE) is widely distributed in human tissues, although its physiological roles remain incompletely defined. It contributes modestly to cholinergic transmission and participates in lipid and ghrelin metabolism.
Samaneh Hajimohammadi, Samaneh Hajimohammadi, Oksana Lockridge, Patrick Masson   +3 more
doaj   +1 more source