Results 151 to 160 of about 7,859 (293)

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Firm‐Level Corporate Social Responsibility and Employees' Affective Outcomes: A Multilevel Approach

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study advances research on corporate social responsibility (CSR) and employees' work attitudes by distinguishing between employee‐level CSR perceptions and firm‐level CSR practices. Prior research has mainly focused on how employees' perceptions of CSR relate to their affective outcomes; this study extends that perspective by jointly ...
Alexander C. Kraaij, Agnieszka Paruzel, Arnoud de Jong   +2 more
wiley   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Développement de Plasmides OriC chez les mollicutes, réplication, spécificité d'hôte et utilisation pour la génomique fonctionnelle

, 2003
Des plasmides réplicatifs oriC contenant l'origine de réplication chromosomique ont été construits pour quatre mycoplasmes responsables de maladies animales : Mycoplasma pulmonis, Mycoplasma mycoides subsp. mycoides LC (MmmLC), Mycoplasma mycoides subsp.
BLANCHARD, Alain, LARTIGUE, Carole
core  

Tailoring surface structures for enhanced single‐droplet jumping condensation

Droplet, EarlyView.
Hierarchically structured superhydrophobic surfaces enable single‐droplet jumping during condensation, promoting continuous surface refreshment and enhanced heat transfer. By combining micro‐ and nano‐scale textures, the optimized design of micropillars enhances the frequency and efficiency of single‐droplet jumping events.
Parsa Faghihi, Jiazheng Liu, Sujan Dewanjee, Siyan Yang, Qiwei Huang, Mohammad Jahidul Hoque, Xiao Yan, Paul V. Braun, Nenad Miljkovic   +8 more
wiley   +1 more source

Uniaxial compressive strength prediction and ratio parameter optimization of titanium tailings composite backfill materials using intelligent hybrid models

Deep Underground Science and Engineering, EarlyView.
Based on the 90 datasets, ERT and four optimization algorithms were used to build four hybrid models to predict the UCS of the backfill body. The SMA‐ERT model was the most effective model, and it can reliably guide the design of the backfill ratio parameters. Abstract This study analyzed the feasibility of using titanium (Ti) tailings as a backfilling
Weijun Liu, Zida Liu, Zhixiang Liu
wiley   +1 more source

Explainable hybrid stacking ensemble method for hard rock pillar stability prediction and engineering applications

Deep Underground Science and Engineering, EarlyView.
This research proposes an interpretable hybrid stacking ensemble framework, optimized by the Sparrow Search Algorithm, to enhance hard rock pillar stability prediction. By integrating six machine learning models—k‐nearest neighbors, support vector machines, random forests, Gradient Boosting Decision Tree, eXtreme Gradient Boosting, and Light Gradient ...
Ning Wang, Guoyan Zhao, Meng Wang, Taraka Pattela   +3 more
wiley   +1 more source

Developing a universal tunnel span classification from global tunnel databases

Deep Underground Science and Engineering, EarlyView.
A universal tunnel span classification system is introduced that incorporates tunnel span, cross‐sectional area, typical tunnel types, and intended uses. Representative flatness ratio values are also provided for each span class. The classification is derived from a comprehensive database of 450 tunnel profiles from 47 countries.
Simon Heru Prassetyo, Inzagi Suhendar, Semmy Andrew Anugerah Djawa Tagi, Bonifacio Bondan Satryojati, Dzakwan Naufal Pratama, Yeremia Sintong Damero, Yudhidya Wicaksana, Erwin Lim, Ridho Kresna Wattimena   +8 more
wiley   +1 more source

Recovery and Repurposing of End‐of‐Life Graphitic Anodes for Green Lithium‐Ion Batteries

EcoEnergy, EarlyView.
This review summarizes the degradation mechanisms of spent graphite anodes in lithium‐ion batteries and highlights key recycling, regeneration, and modification strategies, including hydrometallurgical and pyrometallurgical approaches. It also discusses recent advances in surface engineering, structural regulation, and material hybridization, offering ...
Wei Wei, Weiguo Liu, Jiangqi Zhou
wiley   +1 more source

Sustainable Revival of Spent Lithium Iron Phosphate Cathodes in Li‐Ion Batteries: Recycling and Surface Engineering Approaches

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Schematic illustration of the lifecycle of LiFePO4 cathodes. Lithiation and delithiation reactions happen through its discharging and charging processes. Recycling pathways including hydrometallurgy, pyrometallurgy, and direct regeneration enable sustainable reuse of spent LFP materials. Surface modification approaches (carbon, polymer, and metal/metal
Yan He, Ruigang Wang
wiley   +1 more source