Results 1 to 10 of about 14,403 (142)
Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity. [PDF]
J Clin Invest, 2023 Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and vaccinations targeting the spike protein (S) offer protective immunity against coronavirus disease 2019 (COVID-19).
Aguilar-Bretones M +3 more
europepmc +5 more sources
Is 'original antigenic sin' complicating indian vaccination drive against Covid-19? [PDF]
Hum Vaccin Immunother, 2021 India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge.
Vashishtha VM.
europepmc +5 more sources
Original Antigenic Sin and Respiratory Syncytial Virus Vaccines. [PDF]
Vaccines (Basel), 2019 The original antigenic sin (OAS) theory considers the outcome of the first encounter with an antigen. It favors a memory response to the original antigen upon exposure to a similar or related antigen, and includes both positive and negative impacts of ...
Tripp RA, Power UF.
europepmc +7 more sources
SARS-CoV-2 vaccination in the context of original antigenic sin. [PDF]
Hum Vaccin Immunother, 2022 Immunological memory is the ability of the adaptive immune system to ensure a persistent protective effect after immunization. However, it can also be a limitation to building a sufficient level of protective antibodies specific to new mutations of the ...
Petráš M, Králová Lesná I.
europepmc +5 more sources
Original antigenic sin and pandemic (H1N1) 2009. [PDF]
Emerg Infect Dis, 2010 To the Editor: While pandemic (H1N1) 2009 was in its earliest stages, age distribution data indicated surprisingly few cases among persons >65 years of age. The initial assumption was that few persons >65 years of age had yet to be exposed. However, as more data became available from Mexico, Australia, and the United States, the age distribution ...
Adalja AA, Henderson DA.
europepmc +4 more sources
Thyroid Autoantibodies Display both "Original Antigenic Sin" and Epitope Spreading. [PDF]
Front Immunol, 2017 Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A ...
McLachlan SM, Rapoport B.
europepmc +5 more sources
Understanding original antigenic sin in influenza with a dynamical system. [PDF]
PLoS One, 2011 Original antigenic sin is the phenomenon in which prior exposure to an antigen leads to a subsequent suboptimal immune response to a related antigen. Immune memory normally allows for an improved and rapid response to antigens previously seen and is the ...
Pan K.
europepmc +5 more sources
The wages of original antigenic sin. [PDF]
Emerg Infect Dis, 2010 Morens DM, Burke DS, Halstead SB.
europepmc +4 more sources
Original Antigenic Sin: How Original? How Sinful? [PDF]
Cold Spring Harb Perspect Med, 2021 We review the phenomenon of "original antigenic sin" (OAS) in antibody responses to influenza A virus (IAV) infection or vaccination. OAS refers to the preferential induction of antibodies with higher affinity to priming versus boosting immunogens. We emphasize its mechanistic basis and origins in the basic immunobiology of B-cell responses to myriad ...
Yewdell JW, Santos JJS.
europepmc +4 more sources
Original antigenic sin: not so sinful after all. [PDF]
Trends Immunol, 2023 'Original antigenic sin' predicts that antibody responses to secondary infections with escape mutants are dominated by specificities to the original pathogen. Using transgenic mice in which antibodies are tagged based on cellular origins and kinetics, Schiepers et al.
Baumgarth N.
europepmc +3 more sources