Results 11 to 20 of about 14,422 (161)
The "original antigenic sin" and its relevance for SARS-CoV-2 (COVID-19) vaccination. [PDF]
Clin Immunol Commun, 2021 Imprinting of the specific molecular image of a given protein antigen into immunological memory is one of the hallmarks of immunity. A later contact with a related, but different antigen should not trigger the memory response (because the produced ...
Rijkers GT, van Overveld FJ.
europepmc +2 more sources
Original antigenic sin in dengue - Hoskins effect
APIK Journal of Internal Medicine, 2023 Dengue is a mosquito-borne viral infection found in tropical and subtropical climates worldwide, mostly in urban and semiurban areas. The virus responsible for causing dengue is called dengue virus. There are four dengue virus serotypes, implying that it
Vasantha Kamath, Nisha Davy Olakkengi
doaj +2 more sources
Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19. [PDF]
mSphere, 2021 The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing
Brown EL, Essigmann HT.
europepmc +2 more sources
SARS-CoV-2 vaccination washes away original antigenic sin. [PDF]
Trends Immunol, 2022 According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also
Pillai S.
europepmc +3 more sources
Mapping the Antibody Repertoires in Ferrets with Repeated Influenza A/H3 Infections: Is Original Antigenic Sin Really "Sinful"? [PDF]
Viruses, 2023 The influenza-specific antibody repertoire is continuously reshaped by infection and vaccination. The host immune response to contemporary viruses can be redirected to preferentially boost antibodies specific for viruses encountered early in life, a ...
Einav T +5 more
europepmc +2 more sources
Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS. [PDF]
Front Immunol, 2020 Human coronavirus (HCoV) is one of the most common causes of respiratory tract infections throughout the world. Two phenomena observed so far in the development of the SARS-CoV-2 pandemic deserve further attention. First, the relative absence of clinical
Fierz W, Walz B.
europepmc +2 more sources
"Original Antigenic Sin" in SARS-CoV-2 Vaccination Followed by Infection. [PDF]
Cureus, 2022 Although the "original antigenic sin" (OAS) effects have been predicted against new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), only a few pieces of evidence are available regarding its impact on the safety and effectiveness of coronavirus disease 2019 (COVID-19) vaccines.
Castillo-Aleman YM +4 more
europepmc +3 more sources
Innate immunity and training to subvert original antigenic sin by the humoral immune response. [PDF]
ElifeOriginally defined in the context of influenza vaccines by Thomas Francis Jr. in the late 1950s, original antigenic sin (OAS) refers to the tendency of the immune system to preferentially recall B cell memory against primary antigen after secondary ...
Nait Mohamed FA, Lingwood D.
europepmc +2 more sources
Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies. [PDF]
Proc Natl Acad Sci U S A, 2020 SignificanceHumans are typically infected with influenza viruses in childhood and then continuously exposed to antigenically distinct influenza virus strains throughout life. Antibody responses elicited by initial influenza virus infections can be boosted upon subsequent exposures with antigenically drifted influenza virus strains.
Arevalo CP +10 more
europepmc +4 more sources
Original antigenic sin in dengue revisited. [PDF]
Proc Natl Acad Sci U S A, 2013 The four dengue virus serotypes (DENV-1 to -4) cause the most important arthropod-borne viral disease of humans, with ∼100 million cases each year and over 3 billion people at risk for infection (1). The immune response to DENV infection is complex, because it can be either protective or pathogenic.
Zompi S, Harris E.
europepmc +4 more sources