Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad-Neutralizing Antibody Response against SARS-CoV-2 Omicron Subvariants. [PDF]
MedComm (2020)Original antigenic sin (OAS), or immune imprinting, triggered by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ancestral (WT) strain vaccine, or infection, has led to weakened neutralizing antibody response against Omicron variant like BA ...
Zhang G +15 more
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Original antigenic sin responses to influenza viruses. [PDF]
J Immunol, 2009 Abstract Most immune responses follow Burnet’s rule in that Ag recruits specific lymphocytes from a large repertoire and induces them to proliferate and differentiate into effector cells. However, the phenomenon of “original antigenic sin” stands out as a paradox to Burnet’s rule of B cell engagement.
Kim JH, Skountzou I, Compans R, Jacob J.
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From Original Antigenic Sin to the Universal Influenza Virus Vaccine. [PDF]
Trends Immunol, 2018 Antibody responses are essential for protection against influenza virus infection. Humans are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that immune history influences the magnitude and quality of the antibody response.
Henry C, Palm AE, Krammer F, Wilson PC.
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A speed limit on serial strain replacement from original antigenic sin. [PDF]
Proc Natl Acad Sci U S AAbstractMany pathogens evolve to escape immunity, yet it remains difficult to predict whether immune pressure will lead to diversification, serial replacement of one variant by another, or more complex patterns. Pathogen strain dynamics are mediated by cross-protective immunity, whereby exposure to one strain partially protects against infection by ...
McGough L, Cobey S.
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Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity. [PDF]
Immune Netw, 2016 The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This
Park MS, Kim JI, Park S, Lee I, Park MS.
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Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin. [PDF]
Nat CommunSeveral studies have suggested the imprinting of SARS-CoV-2 immunity by original immune challenge without addressing the formation of the de novo response to successive antigen exposures.
Pušnik J +6 more
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Antibodies with 'Original Antigenic Sin' Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses. [PDF]
PLoS Pathog, 2016 Human antibodies (Abs) elicited by influenza viruses often bind with a high affinity to past influenza virus strains, but paradoxically, do not bind to the viral strain actually eliciting the response.
Linderman SL, Hensley SE.
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The Doctrine of Original Antigenic Sin: Separating Good From Evil. [PDF]
J Infect Dis, 2017 The term "original antigenic sin" was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. These studies did not suggest a reduction in the response to current antigens but instead suggested anamnestic recall of antibody to earlier influenza ...
Monto AS +3 more
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Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection. [PDF]
PLoS One, 2021 BackgroundThe effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood.ObjectivesWe sought to determine the effects of prior exposure to HCoV Betacoronavirus HKU1 spike ...
Lapp SA +9 more
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Strategies to alleviate original antigenic sin responses to influenza viruses. [PDF]
Proc Natl Acad Sci U S A, 2012 Original antigenic sin is a phenomenon wherein sequential exposure to closely related influenza virus variants reduces antibody (Ab) response to novel antigenic determinants in the second strain and, consequently, impairs the development of immune memory.
Kim JH, Davis WG, Sambhara S, Jacob J.
europepmc +4 more sources