The role of social contacts and original antigenic sin in shaping the age pattern of immunity to seasonal influenza. [PDF]
PLoS Comput Biol, 2012 Recent serological studies of seasonal influenza A in humans suggest a striking characteristic profile of immunity against age, which holds across different countries and against different subtypes of influenza.
Kucharski AJ, Gog JR.
europepmc +2 more sources
Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin. [PDF]
mBio, 2017 Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Rajendran M +9 more
europepmc +2 more sources
An In-Depth Analysis of Original Antigenic Sin in Dengue Virus Infection [PDF]
J Virol, 2011 ABSTRACTThe evolution of dengue viruses has resulted in four antigenically similar yet distinct serotypes. Infection with one serotype likely elicits lifelong immunity to that serotype, but generally not against the other three. Secondary or sequential infections are common, as multiple viral serotypes frequently cocirculate. Dengue infection, although
Midgley C +15 more
europepmc +9 more sources
COVID-19 pandemic and original antigenic sin: Future implications on vaccination policy
Journal of Public Health and Primary Care, 2023 Suraj Kapoor
doaj +2 more sources
Age-specific mortality during the 1918 influenza pandemic: unravelling the mystery of high young adult mortality. [PDF]
, 2013 The worldwide spread of a novel influenza A (H1N1) virus in 2009 showed that influenza remains a significant health threat, even for individuals in the prime of life.
Bourbeau, Robert +6 more
core +15 more sources
Earliest infections predict the age distribution of seasonal influenza A cases
eLife, 2020 Seasonal variation in the age distribution of influenza A cases suggests that factors other than age shape susceptibility to medically attended infection.
Philip Arevalo +3 more
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DISQUISITIONS ON ORIGINAL ANTIGENIC SIN [PDF]
The Journal of Experimental Medicine, 1966 Experiments in rabbits were designed to test the two unproven assumptions of the hypothesis proposed in the companion paper (1): that Original Antigenic Sin is fundamentally a restricted anamnestic response, and that there exists a trapping mechanism capable of deflecting antigen from one kind of cell and guiding it to another.
S. Fazekas de St.Groth, R. G. Webster
openaire +2 more sources
Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus [PDF]
, 2014 The source, timing, and geographical origin of the 1918–1920 pandemic influenza A virus have remained tenaciously obscure for nearly a century, as have the reasons for its unusual severity among young adults.
A. Rambaut +29 more
core +2 more sources
Heterologous prime-boost vaccination with H3N2 influenza viruses of swine favors cross-clade antibody responses and protection [PDF]
, 2017 The emergence of multiple novel lineages of H1 and H3 influenza A viruses in swine has confounded control by inactivated vaccines. Because of substantial genetic and geographic heterogeneity among circulating swine influenza viruses, one vaccine strain ...
Claes, Gerwin +8 more
core +2 more sources
Serological Cross-Reactivity in Zoonotic Flaviviral Infections of Medical Importance
Antibodies, 2023 Flaviviruses are enveloped RNA viruses from the family Flaviviridae that comprise many important human pathogenic arboviruses such as Yellow Fever, Dengue, and Zika viruses.
Priscilla Gomes da Silva +4 more
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