Results 161 to 170 of about 119,102 (282)

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka   +12 more
wiley   +1 more source

Differences of Gradient Connectivity and Ventricle Volumes in Long‐Term Sensorineural Hearing Loss Related Cognitive Impairment Correlate With Transcriptional Signatures

open access: yesHuman Brain Mapping, Volume 47, Issue 5, 1 April 2026.
Long‐term hearing loss with cognitive decline shows altered brain gradients, enlarged choroid plexus, and ventricles. These are linked to transcriptomic changes in synaptic, metabolic, and neurodegenerative pathways. ABSTRACT Long‐term sensorineural hearing loss (SNHL) is a prevalent condition associated with an increased risk of cognitive impairment ...
Xiao‐Min Xu   +8 more
wiley   +1 more source

A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer Progression

open access: yesMolecular Carcinogenesis, Volume 65, Issue 4, Page 508-522, April 2026.
ABSTRACT Prostate cancer (PCa) is the second most common cancer and second leading cause of cancer death for American men. Chemoprevention by using phytochemicals offers a promising approach to improve outcomes due to their ability to act on cancer cell metabolism and growth while maintaining low toxicity profiles.
Rachel Clark   +6 more
wiley   +1 more source

Supplementary parenteral arginine corrects hypoargininaemia and rebalances plasma amino acid profiles in very preterm infants receiving parenteral nutrition: A prospective study

open access: yesNutrition in Clinical Practice, Volume 41, Issue 2, Page 619-632, April 2026.
Abstract Background Plasma amino acid (AA) profiles in parenteral nutrition (PN)–dependent very preterm infants (VPIs) consistently show overprovision of essential AA (EAA) and arginine deficiency. This may have implications for growth and immune/inflammatory responses.
Frances Callaghan   +6 more
wiley   +1 more source

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