Results 181 to 190 of about 81,019 (308)

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont   +3 more
wiley   +1 more source

Detection of a Target Nucleic Acid by Ligation‐Assisted Fluorescence Enhancement of a Peptide Nucleic Acid (PNA) Twin Probe via Disulfide Binding

open access: yesBiopolymers, Volume 117, Issue 4, July 2026.
Target‐induced disulfide ligation of PNA twin probes promotes pyrene excimer formation for nucleic acid detection. ABSTRACT The development of methods for detecting specific nucleic acids is important for early diagnosis and treatment of diseases at the genetic level.
Yutaka Ouchi   +9 more
wiley   +1 more source

Recent advances in nonprotein amino acids: insights from function to biosynthesis. [PDF]

open access: yesJ Anim Sci Biotechnol
Zou Y   +9 more
europepmc   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri   +26 more
wiley   +1 more source

THE PREPARATION OF CRYSTALLINE ORNITHINE. THE PICRATES AND MONOSULFATES OF ORNITHINE

open access: yesJournal of Biological Chemistry, 1931
Hubert Bradford Vickery, Charles A. Cook
openaire   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva   +5 more
wiley   +1 more source

Correction: Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase. [PDF]

open access: yesActa Pharmacol Sin
Gong L   +13 more
europepmc   +1 more source

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