Results 191 to 200 of about 87,049 (284)

miR-9394b from Lactobacillus paracasei extracellular vesicles targets iNOS to reprogram host NO-ornithine metabolism and ameliorate DSS-induced murine colitis. [PDF]

NPJ Biofilms Microbiomes
Ding H, Zhang H, Li D, Hu Z, Xiang G, Nie Q, Liu Q, Liang Y, Wang S, Tao S, Li Y.   +10 more
europepmc   +1 more source

Cytotoxic Effects of Medicinal Plant Extracts on HeLa Cells via Redox Imbalance, L‐Arginine Metabolic Reprogramming, and Glycolytic Suppression

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Cancer cells undergo metabolic reprogramming to sustain proliferation, resist apoptosis, and adapt to oxidative stress. In the present study, we comparatively evaluated the anticancer effects of four medicinal plant extracts (Inula helenium, Hypericum alpestre, Rumex obtusifolius, and Alchemilla smirnovii) on HeLa cervical cancer cells, with ...
Mery Kocharyan, Gohar Sevoyan, Hasmik Karapetyan, Anzhela Sargsyan, Mikayel Ginovyan, Nikolay Avtandilyan, Hayarpi Javrushyan   +6 more
wiley   +1 more source

Enhancement and balance of 1,4-butanediamine biosynthesis in Escherichia coli based on modular metabolic engineering. [PDF]

J Genet Eng Biotechnol
Sun X, Li Z, Sun Y, Li D, Zhao K, Ma D, Jiao Y, Lu F, Li M.   +8 more
europepmc   +1 more source

Pyrroloquinoline Quinone Attenuates Traumatic Brain Injury‐Induced Secondary Damage by Activating PINK1/Parkin‐Mediated Mitophagy and Suppressing ASS1/CPS1‐Driven Arginine Biosynthesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Pyrroloquinoline quinone (PQQ) attenuates traumatic brain injury in mice. Multi‐omics integration and molecular docking reveal that PQQ activates PINK1/Parkin‐mediated mitophagy to restore mitochondrial homeostasis while suppressing ASS1/CPS1‐driven arginine biosynthesis to dampen neuroinflammation, identifying a dual‐axis therapeutic mechanism for TBI.
Yanan He, Lu Yu, Yixun Lu, Zhikang Zhou, Ao Li, Lu Wang, Zhili Huang, Yanhong Liu, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source

Active components of <i>Patrinia scabiosifolia</i> and mechanisms of action against methicillin-resistant <i>Staphylococcus Epidermidis</i>. [PDF]

Front Cell Infect Microbiol
Luo Q, Cui W, Ni M, Yang Y, Zhou Y, An L, Liu X.   +6 more
europepmc   +1 more source

Arginase 2 deficiency mitigates sepsis‐associated acute kidney injury by alleviating lipid accumulation

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Spatiotemporal multi‐omics atlas reveals regional metabolic and proteomic specificity during sepsis‐to‐S‐AKI progression. 2. Arginine metabolism is central to S‐AKI pathogenesis, with declining arginine levels correlating with worsening renal function. 3. ARG2 upregulation in renal tubules and macrophages drives tubular lipid accumulation and kidney
Yu Xin, Yanqi Liu, Ning Zhang, Pengfei Huang, Qianqian Zhang, Yinghao Luo, Xinran Wang, Xiuhua Zhang, Tao Wu, Fengye Liu, Yu Xiao, Lifeng Shen, Weiting Zhang, Xibo Wang, Xianglin Meng, Yuping Bai, Xuan Wang, Nan Zhang, Qianghong Xu, Hongxue Meng, Xubin Zheng, Lixin Cheng, Kaijiang Yu, Changsong Wang   +23 more
wiley   +1 more source

Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer. [PDF]

Nat Commun
Pan S, Wang J, Wang B, Wang F, Chen Q, Liu T, Zhang A, Wu S, Li B, Hu H, Yang M, Tao Z, Hu X.   +12 more
europepmc   +1 more source

Ornithine Measurement [PDF]

, 2020
openaire   +1 more source

Testicular toll with viral intrusion: Molecular insights into the impact of chronic HIV infection on male fertility

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
The molecular mechanisms contributing to impaired fertility in HIV+ males remain poorly defined. Using a human immunodeficiency virus (HIV) transgenic (Tg) rat model, we demonstrate key structural and functional sperm regulators including cation channel of sperm (CatSper)1–4 channels and mitochondrial biogenesis genes were markedly downregulated ...
Tousif Ahmed Hediyal, Elizabeth M. Stone, Omar Shukri, Victoria L. Schaal, Amin Foroughi‐Nezhad, Murali Devanaboyina, Josef S. Crenshaw, Amir Elrefaie, Sree Kolli, Camryn N. Davis, Dinesh Pradhan, Sowmya V. Yelamanchili, Gurudutt Pendyala   +12 more
wiley   +1 more source

Dysregulated Metabolism in People Living With HIV in the Modern ART-Era: A Systematic Review of Targeted Metabolomics Studies. [PDF]

Rev Med Virol
Asia LK, Loots DT, Mason S, Jansen Van Vuren E, Williams ME.   +4 more
europepmc   +1 more source