Results 191 to 200 of about 81,019 (308)

Prevalence, Disease Onset and Clinical Outcome in Arginase 1 Deficiency: Cross‐Border Surveillance in Germany, Austria, and Switzerland

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Arginase 1 deficiency (ARG1‐D) is an ultra‐rare urea cycle disorder characterized by progressive spastic paraplegia, developmental delay, epilepsy, and episodic hyperammonemia. Evidence on prevalence and clinical presentation is scarce. Therefore, epidemiology and the phenotypical spectrum were assessed in Germany, Austria, and Switzerland ...
Svenja Scharre, Annette L. Hess, Florian Gleich, Sven F. Garbade, Patrik Feyh, Daniela Karall, Anna Baghdasaryan, Martina Huemer, Julia B. Hennermann, Andreas Hahn, Martin Lindner, Gwendolyn Gramer, Thomas Luecke, Nils Kleinelanghorst, Johannes Haeberle, Amelie S. Lotz‐Havla, Georg F. Hoffmann, Juergen G. Okun, Ulrike Muetze, Stefan Kölker   +19 more
wiley   +1 more source

Identification of Distinct Interacting Proteins of Giardia lamblia Centrins Using Yeast Two‐Hybrid Assays

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Giardia lamblia, a protozoan parasite that causes diarrhea in humans, contains two centrins implicated in cellular morphology and cell division. To identify proteins interacting with each G. lamblia centrin (GlCent), we performed a yeast two‐hybrid assay.
Mee Young Shin, Juri Kim, Soon‐Jung Park   +2 more
wiley   +1 more source

Fatal Late-Onset Ornithine Transcarbamylase Deficiency in an Adolescent: A Case Report. [PDF]

Cureus
Christou E, Ntouzepi K, Machaira M, Tziouvas K, Patsoura A.   +4 more
europepmc   +1 more source

Endophyte‐induced systemic spatial reprogramming of metabolism in Populus trichocarpa roots under drought

New Phytologist, Volume 251, Issue 1, Page 438-454, July 2026.
Summary Beneficial, facultative endophytes help plants thrive in challenging environments by altering their host's metabolism, but how these cellular scale metabolic changes propagate to the systems biology scale is unknown. In this work, we employed a high‐resolution chemical imaging approach to map metabolic changes at the Populus trichocarpa root ...
Jayde Aufrecht, Dušan Veličković, Robert Tournay, Sneha Couvillion, Vimal Balasubramanian, Tanya Winkler, Daisy Herrera, Robert Stanley, Sharon L. Doty, Amir H. Ahkami   +9 more
wiley   +1 more source

Nitrogen Isotope Effects in Urea Metabolism: From Biochemistry to ¹⁵N Natural Abundance in Cancer. [PDF]

Int J Mol Sci
Tea I, Tcherkez G.
europepmc   +1 more source

Hofmann Degradation of Asparagine and Glutamine as an Efficient Approach for the Synthesis of Derivatized Lysine Homologs

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
A practical and scalable route to C1 and C2 lysine homologs has been developed using Hofmann degradation of N‐protected L‐asparagine and L‐glutamine as the key step. These short‐tether scaffolds enable efficient synthesis of diverse Fmoc‐protected noncanonical amino acids (ncAAs) bearing donor, acceptor, redox‐active, and fluorescent residues.
Adelaide R. Mashweu, François J. De Beer, Jolien Bertouille, Steven Ballet, Charlotte Martin, Ulrich Hennecke, Charlene Marais, Vladimir A. Azov   +7 more
wiley   +1 more source

A Complex Case of Ornithine Transcarbamylase Deficiency in a Patient With Severe Comorbid Conditions. [PDF]

Clin Case Rep
Khan M, Rafique SA, Khan S, Shah A, Karan A, Khalid AA, Afridi A, Tamim H, Talukder MRT.   +8 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, Volume 16, Issue 6, Page 1060-1073, June 2026.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Acetate uptake alleviates propionate-mediated growth restriction in <i>Yersinia enterocolitica</i>. [PDF]

Infect Immun
Muramatsu MK, Cole D, Perez-Orozco SJ, Winter SE.   +3 more
europepmc   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an In Vivo Murine Burn Model Study

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source