Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice [PDF]
Pulmonary Circulation, 2020 Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of
P.H. Gebauer +4 more
doaj +2 more sources
DMSO-tolerant ornithine decarboxylase (ODC) tandem assay optimised for high-throughput screening [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ornithine decarboxylase (ODC), the first rate-limiting enzyme in polyamine synthesis, has emerged as a therapeutic target for cancer and Alzheimer’s disease (AD).
Mingu Gordon Park +2 more
doaj +2 more sources
Metabolic Characterization of Hyoscyamus niger Ornithine Decarboxylase [PDF]
Frontiers in Plant Science, 2019 Ornithine decarboxylase (ODC) catalyzes ornithine decarboxylation to yield putrescine, a key precursor of polyamines, and tropane alkaloids (TAs). Here, to investigate in depth the role of ODC in polyamine/TA biosynthesis and to provide a candidate gene ...
Tengfei Zhao +9 more
doaj +2 more sources
Target of Rapamycin Mediated Ornithine Decarboxylase Antizyme Modulate Intracellular Putrescine and Ganoderic Acid Content in Ganoderma lucidum [PDF]
Microbiology Spectrum, 2022 Putrescine (Put) has been shown to play an important regulatory role in cell growth in organisms. As the primary center regulating the homeostasis of polyamine (PA) content, ornithine decarboxylase antizyme (AZ) can regulate PA content through feedback ...
Tao Wu +12 more
doaj +2 more sources
Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase. [PDF]
PLoS ONE, 2019 Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, organic cations that are implicated in many cellular processes. The enzyme is regulated at the post-translational level by an unusual system that includes antizymes (AZs ...
Ana Lambertos, Rafael Peñafiel
doaj +2 more sources
Ornithine decarboxylase as a therapeutic target for endometrial cancer. [PDF]
PLoS ONE, 2017 Ornithine Decarboxylase (ODC) a key enzyme in polyamine biosynthesis is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. We noted ubiquitous expression of ODC1 in our published endometrial cancer gene array data and
Hong Im Kim +9 more
doaj +2 more sources
A safety catch for ornithine decarboxylase degradation [PDF]
Microbial Cell, 2015 Christof Taxis
doaj +2 more sources
Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate. [PDF]
PLoS ONE, 2015 The prostate is a male accessory sex gland that produces secretions in seminal fluid to facilitate fertilization. Prostate secretory function is dependent on androgens, although the mechanism by which androgens exert their effects is still unclear ...
Melissa Gamat +4 more
doaj +1 more source
The effect of folic acid treatment on the post-harvest life of cucumber through influencing the activity of enzymes involved in the biosynthesis of proline, polyamine, and chlorophyll-degradation [PDF]
فیزیولوژی محیطی گیاهی, 2022 In this study, the mechanism of cold stress tolerance in cucumber fruits pretreated with folic acid was investigated. Control group and the group treated with 5 mgL-1 folic acid were stored for 15 days at 4 °-C.
Parviz Malekzadeh
doaj +1 more source
Production of Putrescine and Cadaverine by Paucilactobacillus wasatchensis
Frontiers in Microbiology, 2022 Lactic acid bacteria (LAB) play a key role in many food fermentations. However, some LAB species can also cause food spoilage, e.g., through the formation of biogenic amines.
Hélène Berthoud +2 more
doaj +1 more source