Results 51 to 60 of about 4,733 (152)

The diuretic torasemide does not prevent aldosterone-mediated mineralocorticoid receptor activation in cardiomyocytes.

PLoS ONE, 2013
Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid signaling is deleterious during the evolution of cardiac failure, as evidenced by the benefits
Basile Gravez, Antoine Tarjus, Ruben Jimenez-Canino, Soumaya El Moghrabi, Smail Messaoudi, Diego Alvarez de la Rosa, Frederic Jaisser   +6 more
doaj   +1 more source

Childhood Environmental Exposures and Adult Disease

Pediatric Pulmonology, Volume 61, Issue 4, April 2026.
ABSTRACT The association of early life adverse events with worse adult outcomes was first proposed by David Barker, the Developmental Origins of Health and Disease (DOHaD). Subsequently we have learned that adverse exposures are not merely important during pregnancy, but also exert transgenerational effects.
Andrew Bush
wiley   +1 more source

pH-dependency of basic ligand binding to α1-acid glycoprotein (orosomucoid) [PDF]

Biochemical Journal, 1991
The binding interactions of a series of basic ligands with alpha 1-acid glycoprotein (AAG) were examined as a function of pH. The binding to AAG increased with increasing pH, and the binding data were satisfactorily fitted to a model that incorporates the effect of pH and discriminates the association constants of neutral (non-protonated) and ...
Urien, S, Brée, F, Testa, B, Tillement, J P   +3 more
openaire   +3 more sources

Plasma Proteomic Signatures of Pediatric Sepsis Reveal Persistent Inflammation and Phase‐Specific Biomarkers

FASEB BioAdvances, Volume 8, Issue 3, March 2026.
We enrolled a pediatric sepsis cohort at acute and recovery phases for plasma proteomics analysis. Abundantly expressed proteins in sepsis were identified and subjected to machine learning. In addition, the data was compared to adult sepsis and sterile inflammation.
Fahd Alhamdan, Yi‐Cheng Sin, Erik Malm, Hanna Van Pelt, Samuel Kim, LeeAnn Higgins, Yue Chen, Koichi Yuki   +7 more
wiley   +1 more source

Comparison of Lung Inflammatory and Transcriptional Responses in Mice and Rats Following Pulmonary Exposure to a Fiber Paradigm-Compatible and Non-Compatible MWCNT

Nanomaterials
Inhalation of multi-walled carbon nanotubes (MWCNTs) poses potential health risks due to their structural similarity to asbestos and their ability to induce chronic lung inflammation, fibrosis, and lung cancer in animal models.
Laura Aliisa Saarimäki, Pernille Høgh Danielsen, Kristina Bram Knudsen, Sarah Søs Poulsen, Sabina Halappanavar, Henrik Wolff, Pia Anneli Sofia Kinaret, Dario Greco, Ulla Vogel   +8 more
doaj   +1 more source

Measurement of Urinary Gc-Globulin by a Fluorescence ELISA Technique: Method Validation and Clinical Evaluation in Septic Patients—A Pilot Study

Molecules, 2023
A major complication of sepsis is the development of acute kidney injury (AKI). In case of acute tubular damage, Gc-globulin, a known serum sepsis marker is increasingly filtrated into the urine therefore, urinary Gc-globulin (u-Gc) levels may predict ...
Tamás Kőszegi, Zoltán Horváth-Szalai, Dániel Ragán, Brigitta Kósa, Balázs Szirmay, Csilla Kurdi, Gábor L. Kovács, Diána Mühl   +7 more
doaj   +1 more source

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, Volume 604, Issue 4, Page 1558-1574, 15 February 2026.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Level of the proteins of the acute phase as criterions of the antibacterial therapy effectiveness in the E.coli associated experimental peritonitis

Zaporožskij Medicinskij Žurnal, 2013
Introduction. Peritonitis is accompanied by increase of acute-phase proteins levels. C – reactive protein (CRP) is acute – phase protein which is produced in human organism in response to tissue injury, infection or inflammation. CRP is produced in small
V. V. Minukhin, O. Y. Kosilova
doaj   +1 more source

Orosomucoid: a promising biomarker for the assessment of exercise-induced fatigue triggered by basic combat training

BMC Sports Science, Medicine and Rehabilitation, 2022
Background Orosomucoid (ORM) is a positive acute phase protein verified to be upregulated in various forms of exercise-induced fatigued (EIF) rodents. However, its association with EIF among human beings remained unknown.
Yi Ruan, Ke-fa Xiang, Hui-min Zhang, Zhen Qin, Yang Sun, Jing-jing Wan, Wei Gu, Xia Liu   +7 more
doaj   +1 more source

Proteomic Evidence of Complement and Coagulation Pathway Dysregulation in Transfusion‐Dependent Thalassemia

Advances in Hematology, Volume 2026, Issue 1, 2026.
Transfusion‐dependent thalassemia (TDT) is characterized by chronic hemolysis, ineffective erythropoiesis, and iron overload, resulting in persistent oxidative stress and systemic inflammation. Patients with TDT are also at increased risk of thromboembolic complications, suggesting disturbance of hemostatic and immune‐related pathways.
Afshan Sumera, Ammu K. Radhakrishnan, Abdul Aziz Baba, Soon Keng Cheong, Kalyani Sen   +4 more
wiley   +1 more source