Results 61 to 70 of about 4,733 (152)

Association between peripheral blood mononuclear cell expression and the asthma predictive index in preschool children

Journal of International Medical Research, 2019
Objective This study aimed to assess whether orosomucoid 1-like 3 (ORMDL3) expression and environmental and clinical factors are associated with wheezing episodes in preschool children.
Yaqin Li, Lanfang Cao, Qing Yu, Haiyan Xue, Yanming Lu   +4 more
doaj   +1 more source

Inflammatory tone in liver and adipose tissue in dairy cows experiencing a healthy transition from late pregnancy to early lactation

Journal of Dairy Science, 2023
: The transition from late pregnancy (LP) to early lactation (EL) in dairy cows is characterized by a major reorganization of the metabolic activities of liver and adipose tissue in support of milk synthesis.
M.M. McGuckin, S.L. Giesy, T.R. Overton, Y.R. Boisclair   +3 more
doaj   +1 more source

Serum Sialic Acid as a Biomarker of Inflammation and Infection: Insights From Veterinary Medicine

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Serum sialic acid (SSA) levels, including total sialic acid (TSA), lipid‐bound sialic acid (LBSA), and protein‐bound sialic acid (PBSA), have been extensively studied as biomarkers of inflammation and infection across various species and diseases. In parasitemic sheep, elevated SSA levels likely reflect host–pathogen interactions and immune activation.
Tina Yaghoobpour, Milad Faraji, Saeed Nazifi, Antonio Ortega-Pacheco   +3 more
wiley   +1 more source

Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib

International Journal for Parasitology: Drugs and Drug Resistance, 2014
In the search for new drugs and drug targets to treat the flatworm disease schistosomiasis, protein kinases (PKs) have come under particular scrutiny because of their essential roles in developmental and physiological processes in schistosome parasites ...
Svenja Beckmann, Thavy Long, Christina Scheld, Rudolf Geyer, Conor R. Caffrey, Christoph G. Grevelding   +5 more
doaj   +1 more source

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, Volume 292, Issue 22, Page 6054-6074, November 2025.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?

Therapeutics and Clinical Risk Management, 2019
Balázs Németh,1,2 Iván Péter,1 Imre Boncz,1 Anna Jagicza,1 István Kiss,2 Ágnes Csergő,2 Tamás Kőszegi,3,4 Péter Kustán,3,4 Iván G Horváth,5 Zénó ...
Németh B, Péter I, Boncz I, Jagicza A, Kiss I, Csergő Á, Kőszegi T, Kustán P, Horváth IG, Ajtay Z   +9 more
doaj  

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1598-1615, October 2025.
ABSTRACT Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations.
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
wiley   +1 more source

A chronic fatigue syndrome – related proteome in human cerebrospinal fluid

BMC Neurology, 2005
Background Chronic Fatigue Syndrome (CFS), Persian Gulf War Illness (PGI), and fibromyalgia are overlapping symptom complexes without objective markers or known pathophysiology. Neurological dysfunction is common.
Baraniuk James N, Casado Begona, Maibach Hilda, Clauw Daniel J, Pannell Lewis K, Hess S Sonja   +5 more
doaj   +1 more source

Society for Endocrinology Clinical Practice Guideline for the Evaluation of Androgen Excess in Women

Clinical Endocrinology, Volume 103, Issue 4, Page 540-566, October 2025.
ABSTRACT Context Androgen excess is common in women and refers to clinical or biochemical evidence of elevated androgenic steroids such as testosterone. It is associated with underlying polycystic ovary syndrome in the majority of cases. However severe androgen excess is less common and may indicate the presence of underlying adrenal or ovarian ...
Yasir S. Elhassan, James M. Hawley, Leanne Cussen, Ali Abbara, Sophie A. Clarke, Punith Kempegowda, Rima K. Dhillon‐Smith, Puja Thadani, Maureen Busby, Lucy Owusu‐Darkwah, Rachel Marrington, W. Colin Duncan, Robert K. Semple, Richard Quinton, Michael W. O'Reilly   +14 more
wiley   +1 more source

Network Modeling of Biomarker Systems in Liver Steatosis and Fibrosis

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease causes hepatic fat accumulation (steatosis) and fibrosis, which can be measured with ultrasound elastography imaging. The dependencies of elastography‐derived hepatic steatosis and fibrosis measures with chronic inflammation, disease states, and physiological determinants of drug dosing ...
Amruta Gajanan Bhat, Murali Ramanathan
wiley   +1 more source