Results 41 to 50 of about 4,733 (152)

Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort. [PDF]

PLoS ONE, 2017
Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin ...
Iram Faqir Muhammad, Yan Borné, Gerd Östling, Cecilia Kennbäck, Mikael Gottsäter, Margaretha Persson, Peter M Nilsson, Gunnar Engström   +7 more
doaj   +1 more source

ORM 1 as a biomarker of increased vascular invasion and decreased sorafenib sensitivity in hepatocellular carcinoma

Biomolecules & Biomedicine, 2022
This study aimed to clarify the role of Orosomucoid 1 (ORM1) in the development and therapy resistance in hepatocellular carcinoma (HCC). The mRNA expression level of ORM1 was analyzed via integrative analysis of Gene Express Omnibus (GEO) and The ...
Jiangning Gu, Shiqi Xu, Xiang Chen, Haifeng Luo, Guang Tan, Wenjing Qi, Feng Ling, Chenqi Wang, Feiliyan Maimaiti, Yunlong Chen, Lili Yang, Menghong Yin, Dan Chen   +12 more
doaj   +1 more source

Associations of genotype variants of single nucleotide polymorphism of gene orosomucoid-1-like-protein 3 and atopic diseases at children.

Medičnì Perspektivi, 2019
The paper presents data of the firstly conducted in Ukraine own study of associations of the single nucleotide polymorphism (SNP) rs7216389 of orsomucoid-1-like protein 3 gene (ORMDL3) variants’ with atopic diseases in children.
V. O. Dytiatkovsky, O. E. Abaturov, N. V. Naumenko, N. L. Pinayeva, O. O. Alifirenko   +4 more
doaj   +1 more source

Dynamic changes of serum protein in rats with acute intoxication of Chinese cobra snake venom by proteomic analysis

Forensic Sciences Research, 2020
To elucidate the toxic mechanism of snake venom at the protein level, proteomics technology was applied to investigate the effect of venom on circulation in the mammalian body.
Hui Yan, Ping Xiang, Jingshuo Zhang, Liqi Xie, Min Shen   +4 more
doaj   +1 more source

Promoter characterization and role of cAMP/PKA/CREB in the basal transcription of the mouse ORMDL3 gene. [PDF]

PLoS ONE, 2013
Orosomucoid 1-like 3 (ORMDL3) gene was strongly linked with the development of asthma in genetic association studies, and its expression could be significantly induced by allergen in airway epithelial cells of mice.
Li-Li Zhuang, Rui Jin, Liang-Hua Zhu, Hua-Guo Xu, Yue Li, Shan Gao, Jia-Yin Liu, Guo-Ping Zhou   +7 more
doaj   +1 more source

Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population

Iranian Journal of Allergy, Asthma and Immunology, 2018
Orosomucoid 1-like 3 (ORMDL3) gene, located on chromosome 17q21, is an asthma candidate gene that encodes ORMDL3. This molecule has been reported to play a role in airway remodeling and bronchial hyper-responsiveness.
Ilghar Zeinaly, Naghmeh Vossoughi, Daniel Elieh Ali Komi, Tohid Kazemi, Zohreh Babaloo, Alireza Razavi, Mohammad Sajay-Asbaghi, Mahnaz Sadeghi-Shabestari   +7 more
doaj   +1 more source

Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort

Angewandte Chemie, Volume 137, Issue 46, November 10, 2025.
Validating biomarkers of disease is necessary for clinical use. The Health Surveillance Panel (83 peptides from 57 proteins) was developed as a PRM assay and evaluated using the Stellar‐MS platform. The assay was validated with a large clinical cohort of inflammatory bowel disease patients alongside quality controls.
Qin Fu, Philip M. Remes, Jihyeon Lee, Cristina Jacob, Dalin Li, Manasa Vegesna, Koen Raedschelders, Ali Haghani, Emebet Mengesha, Philip Debbas, Esthelle Hoedt, Sandy Joung, Susan Cheng, Scott Peterman, Justyna Fert‐Bober, Gil Y. Melmed, Dermot P.B. McGovern, Christopher I. Murray, Jennifer E. Van Eyk   +18 more
wiley   +2 more sources

Alpha 1‐acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria. [PDF]

British Journal of Clinical Pharmacology, 1991
1. Plasma concentrations of alpha 1‐acid glycoprotein (AAG) and plasma protein binding of quinine were measured in 97 Thai adults with acute falciparum malaria. There was a linear relationship between log AAG and percentage quinine binding (r = 0.71, P less than 0.001) in vivo, which was similar to that observed in vitro; the slopes and intercepts of ...
Silamut, K, Molunto, P, Ho, M, Davis, T, White, N   +4 more
openaire   +3 more sources

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source