Results 31 to 40 of about 4,733 (152)

Personalized genotype-associated diagnosis of the progression of atopic march in children

Zdorovʹe Rebenka, 2023
Background. Atopic march (AM) is the progression of atopic lesions (AL) from monoorganic phenotypes (MOPh), usually atopic dermatitis (AD), to a combination with allergic rhinitis/rhinoconjunctivitis (AR/ARC) and bronchial asthma (BA) in the full-scope ...
V.O. Dytiatkovskyi
doaj   +1 more source

Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation [PDF]

International Immunology, 2020
Abstract Chronic allograft rejection is the most common cause of long-term allograft failure. One reason is that current diagnostics and therapeutics for chronic allograft rejection are very limited. We here show that enhanced NFκB signaling in kidney grafts contributes to chronic active antibody-mediated rejection (CAAMR), which is a ...
Higuchi, Haruka, Kamimura, Daisuke, Jiang, Jing-Jing, Atsumi, Toru, Iwami, Daiki, Hotta, Kiyohiko, Harada, Hiroshi, Takada, Yusuke, Kanno-Okada, Hiromi, Hatanaka, Kanako C., Tanaka, Yuki, Shinohara, Nobuo, Murakami, Masaaki   +12 more
openaire   +3 more sources

Urinary Proteomics Identifying Novel Biomarkers for the Diagnosis of Adult-Onset Still’s Disease

Frontiers in Immunology, 2020
Adult-onset Still’s disease (AOSD) is a systemic, multigenic autoinflammatory disease, and the diagnosis of AOSD must rule out neoplasms, infections, and other autoimmune diseases. Development of a rapid and efficient but non-invasive diagnosis method is
Yue Sun, Fan Wang, Zhuochao Zhou, Jialin Teng, Yutong Su, Huihui Chi, Zhihong Wang, Qiongyi Hu, Jinchao Jia, Tingting Liu, Honglei Liu, Xiaobing Cheng, Hui Shi, Yun Tan, Chengde Yang, Junna Ye   +15 more
doaj   +1 more source

Immunolocalization of VEGF-A and orosomucoid-1 in odontogenic myxoma.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2016
The aim of the present study was to determine and establish the immunohistochemical distribution of VEGF-A and ORM-1 protein in odontogenic myxomas to suggest a possible function in the biological behavior of odontogenic myxomas.A total of 33 odontogenic myxoma cases and three tooth germs were included.
Bologna-Molina, Ronell, Mosqueda Taylor, Adalberto, Domínguez Malagón, Hugo, Salazar Rodríguez, Sirced, Tapia-Repetto, Gabriel, González González, Rogelio, Molina-Frechero, Nelly   +6 more
openaire   +3 more sources

ORMDL3 overexpression facilitates FcεRI‐mediated transcription of proinflammatory cytokines and thapsigargin‐mediated PERK phosphorylation in RBL‐2H3 cells

Immunity, Inflammation and Disease, 2021
Introduction The chromosomal region 17q21 harbors the human orosomucoid‐like 3 (ORMDL3) gene and has been linked to asthma and other inflammatory diseases.
Kazuhiro Ogi, Tetsuji Takabayashi, Kaori Tomita, Masafumi Sakashita, Taiyo Morikawa, Takahiro Ninomiya, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda   +8 more
doaj   +1 more source

Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients. [PDF]

Diabetes Metab Res Rev
ABSTRACT Aim The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non‐HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D.
Mertens IM, Keymeulen B, Gorus FK, Van De Casteele M, Belgian Diabetes Registry.   +4 more
europepmc   +2 more sources

Orosomucoid-1 Arises as a Shared Altered Protein in Two Models of Multiple Sclerosis

Neuroscience, 2023
Multiple sclerosis (MS) is a complex autoimmune and neurodegenerative disorder that affects the central nervous system (CNS). It is characterized by a heterogeneous disease course involving demyelination and inflammation. In this study, we utilized two distinct animal models, cuprizone (CPZ)-induced demyelination and experimental autoimmune ...
Sonsoles Barriola, Lina María Delgado-García, Paz Cartas-Cejudo, Ignacio Iñigo-Marco, Joaquín Fernández-Irigoyen, Enrique Santamaría, Laura López-Mascaraque   +6 more
openaire   +3 more sources

pH-dependence of warfarin binding to α1-acid glycoprotein (orosomucoid) [PDF]

Biochemical Journal, 1993
The binding of warfarin to alpha 1-acid glycoprotein (AAG) was found to increase with decreasing pH. The u.v.-visible difference spectra generated upon binding to AAG at pH 5.0 or 7.4 showed warfarin to bind as the anion. Warfarin-binding data were satisfactorily fitted to a model that incorporates the effect of pH and discriminates the association ...
Urien, S, Brée, F, Testa, B, Tillement, J P   +3 more
openaire   +3 more sources

OROSOMUCOID PROTEIN 1 regulation of sphingolipid synthesis is required for nodulation in Aeschynomene evenia

Plant Physiology, 2023
Abstract Legumes establish symbiotic interactions with nitrogen-fixing rhizobia that are accommodated in root-derived organs known as nodules. Rhizobial recognition triggers a plant symbiotic signaling pathway that activates 2 coordinated processes: infection and nodule organogenesis.
Nouwen, Nico, Pervent, Marjorie, El M’chirgui, Franck, Tellier, Frédérique, Rios, Maëlle, Horta Araújo, Natasha, Klopp, Christophe, Gressent, Frédéric, Arrighi, Jean-François   +8 more
openaire   +4 more sources

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Frontiers in Immunology, 2021
Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li   +10 more
doaj   +1 more source