Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling. [PDF]
Biomed Res Int, 2020 Doxorubicin (DOX) is an effective anticancer drug, but its therapeutic use is limited by its cardiotoxicity. The principal mechanisms of DOX‐induced cardiotoxicity are oxidative stress and apoptosis in cardiomyocytes. Orosomucoid 1 (ORM1), an acute‐phase protein, plays important roles in inflammation and ischemic stroke; however, the roles and ...
Cheng X +6 more
europepmc +4 more sources
Targeting ORM1-CCR5 axis inhibits the aggressive phenotype of synovial fibroblasts and alleviates RA [PDF]
Open MedicineThe present study focused on exploring the role of orosomucoid 1 (ORM1) in rheumatoid arthritis (RA).
Liu Min +5 more
doaj +2 more sources
Identification and validation of a nomogram for psoriasis diagnosis: a novel biomarker combination with stable high expression in the early stage [PDF]
Frontiers in MedicineObjectivePsoriasis is a complex chronic inflammatory skin disease. While typical cases are often diagnosed based on clinical features, achieving objective assessment of disease activity and precise early-stage identification remains a clinical focus ...
Juanli Liu +3 more
doaj +2 more sources
The acute phase reactant orosomucoid-1 is a bimodal regulator of angiogenesis with time- and context-dependent inhibitory and stimulatory properties. [PDF]
PLoS ONE, 2012 Tissues respond to injury by releasing acute phase reaction (APR) proteins which regulate inflammation and angiogenesis. Among the genes upregulated in wounded tissues are tumor necrosis factor-alpha (TNFα) and the acute phase reactant orosomucoid-1 ...
Giovanni Ligresti +4 more
doaj +2 more sources
Molecular Dynamics Modeling of Potential Osteoarthritic Biomarkers [PDF]
LifeOsteoarthritis (OA) is one of the most common forms of arthritis and is commonly characterized by the breakdown of the hyaline cartilage and synovial fluid in joints. The body naturally responds by releasing proteins with specific functions to combat the
Joshua Mallets +2 more
doaj +2 more sources
Serum and Urinary Orosomucoid in Young Patients With Type 1 Diabetes [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2016 Orosomucoid is an acute-phase serum protein that is upregulated in urine samples of patients with diabetic nephropathy. We assessed serum and urinary orosomucoid levels in children and adolescents with type 1 diabetes and their relation to microvascular complications and carotid intima–media thickness (CIMT).
Névine G Andrawes +1 more
exaly +3 more sources
The increased excretion of urinary orosomucoid 1 as a useful biomarker for bladder cancer. [PDF]
Am J Cancer Res, 2016 Improving the early detection rate and prediction of bladder cancer remains a great challenge in management of this disease. To examine the value of urinary orosomucoid 1 (ORM1) for the early detection and surveillance of bladder cancer, two-dimensional differential gel electrophoresis (2-DE) and matrix-assisted laser desorption time-of-flight mass ...
Li F +7 more
europepmc +2 more sources
Orosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9 [PDF]
Bioengineered, 2021 Qiong Luo, Jun Yin
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Orosomucoid 2 promotes colorectal cancer liver metastasis by suppressing natural killer cell-mediated antitumor immunity by remodeling the serine and one-carbon metabolism pathway [PDF]
Molecular CancerBackground The liver is the most common site of distant metastasis in colorectal cancer (CRC), and liver metastasis (LM) remains the leading cause of CRC-related mortality.
Jiamin Zhou +9 more
doaj +2 more sources
Conventional and Novel Inflammatory Biomarkers in Chronic Heart Failure Patients with Atrial Fibrillation [PDF]
Medicina(1) Background and Objectives: Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with increased morbidity and mortality both in the general population and heart failure patients.
Gregor Vercek +5 more
doaj +2 more sources