Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis [PDF]
Advanced ScienceTemporomandibular joint osteoarthritis (TMJOA) is one of the most complex temporomandibular disorders. Cartilage matrix degradation results in the infiltration of nerves, blood vessels, and inflammatory cells, which disrupts chondrocyte function ...
Dahe Zhang +5 more
doaj +5 more sources
Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes [PDF]
EBioMedicine, 2017 The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in serum
Xian-Yang Qin +2 more
exaly +7 more sources
Salivary orosomucoid 1 as a biomarker of hepatitis B associated hepatocellular carcinoma [PDF]
Scientific Reports, 2022 Saliva is rich in proteins, DNA, RNA and microorganisms, and can be regarded as a biomarker library. In order to explore a noninvasive and simple means of early screening for liver cancer, proteomics was used to screen salivary markers of hepatitis B ...
Jiaoxia He +5 more
doaj +4 more sources
Orosomucoid 1 is a Potential Prognostic Biomarker for Uterine Sarcoma [PDF]
Technology in Cancer Research & TreatmentIntroduction Uterine sarcoma (US) is a rare tumor characterized by high aggressiveness, a tendency for recurrence and distant metastasis, and an extremely poor prognosis.
Dan Yuan MS +5 more
doaj +4 more sources
Excretion of urinary orosomucoid 1 protein is elevated in patients with chronic heart failure. [PDF]
PLoS ONE, 2014 Easily screening markers for early detection of chronic heart failure (CHF) are lacking. We identified twenty differently expressed proteins including orosomucoid 1(ORM1) in urine between patients with CHF and normal controls by proteomic methods ...
Li-na Hou +8 more
doaj +5 more sources
Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer [PDF]
Cell Adhesion & MigrationThe research endeavors to expound the role of ORM1 in bladder cancer (BCa) and the implied response mechanism. RT-qPCR and Western blotting examined ORM1 and S100A12 expression. Functional experiments assessed the cellular phenotypes.
Zhe Liu, Xiaofeng Pu
doaj +4 more sources
Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization [PDF]
Scientific Reports, 2023 Approximately 25–30% of those affected by colorectal cancer (CRC), the most prevalent gastrointestinal malignancy, develop metastases. The survival rate of patients with liver metastasis of CRC (CRLM) remains low owing to its unpredictability and a lack ...
Lei Yue +7 more
doaj +2 more sources
Orosomucoid-1 Expression in Ameloblastoma Variants. [PDF]
Int J Mol Cell Med, 2016 Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus.
García-Muñoz A +7 more
europepmc +4 more sources
The orosomucoid 1 protein (α1 acid glycoprotein) is overexpressed in odontogenic myxoma. [PDF]
Proteome Sci, 2012 AbstractBackgroundOdontogenic myxoma (OM) is a benign, but locally invasive, neoplasm occurring in the jaws. However, the molecules implicated in its development are unknown. OM as well as Dental Follicle (DF), an odontogenic tissue surrounding the enamel organ, is derived from ectomesenchymal/mesencyhmal elements.
García-Muñoz A +8 more
europepmc +6 more sources
Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype. [PDF]
Cytokine, 2015 Orosomucoid (ORM, composed of two isoforms, ORM1 and ORM2) has been described as an inducer of M2 macrophages, which are cells that decrease host antibacterial innate immunities. However, it is unknown which phenotypes of M2 macrophages are induced by ORM.
Nakamura K +4 more
europepmc +4 more sources