Results 21 to 30 of about 4,733 (152)

Orosomucoid 1 Participates in Alveolar Hypercoagulation and Fibrinolytic Inhibition Involving NF-κB Signaling Pathway in LPS-Induced ARDS. [PDF]

FASEB J
ORM1 promotes LPS‐induced ARDS by activating NF‐κB in alveolar epithelial II cells, upregulating TF/PAI‐1 to cause hypercoagulation and fibrinolysis inhibition, leading to lung injury. ORM1 knockdown reverses these effects, indicating therapeutic potential.
Chen X, Liu Y, Mu S, Chen T, Yuan J, Xiao C, Dong Q, Li Q, Wang Y, Chen Q, Li S, Li W, Shen F.   +12 more
europepmc   +2 more sources

Proteomic analysis reveals candidate molecules to mediate cortical pathology and identify possible biomarkers in an animal model of multiple sclerosis [PDF]

Frontiers in Immunology
IntroductionMultiple Sclerosis (MS) is a complex neurodegenerative disease marked by recurring inflammatory episodes, demyelination, axonal damage, and subsequent loss of function.
Berenice Anabel Silva, María Celeste Leal, María Isabel Farias, Agustín Nava, Agustín Nava, Daniela Inés Galván, Elmer Fernandez, Elmer Fernandez, Fernando Juan Pitossi, Carina Cintia Ferrari   +9 more
doaj   +2 more sources

Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: A useful tool for precision medicine strategies

Frontiers in Medicine, 2022
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity.
Cristina Ruiz-Romero, Cristina Ruiz-Romero, Patricia Fernández-Puente, Lucía González, Anna Illiano, Anna Illiano, Lucía Lourido, Rocío Paz, Patricia Quaranta, Eva Perez-Pampín, Antonio González, Francisco J. Blanco, Francisco J. Blanco, Valentina Calamia   +13 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Association Between Levels of the Acute Phase Proteins Alpha-1-Acid Glycoprotein and C-Reactive Protein and Serum Concentrations of Clozapine: A Study of 1106 Therapeutic Drug Monitoring Samples. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Several publications have reported elevated clozapine concentrations in patients experiencing infections or inflammatory reactions. Proposed mechanisms include increased levels of pro‐inflammatory cytokines that may inhibit clozapine metabolism and enhanced binding of clozapine to the acute phase protein alpha‐1‐acid glycoprotein (AGP).
Espnes KA, Spigset O, Bratt GE, Tilrem M, Hamnes S, Skogvoll E, Skråstad RB.   +6 more
europepmc   +2 more sources

Air pollution and biomarkers of cardiovascular disease and inflammation in the Malmö Diet and Cancer cohort

Environmental Health, 2022
Introduction Air pollution is associated with increased risk of cardiovascular disease, possibly through chronic systemic inflammation that promotes the progression of atherosclerosis and the risk of cardiovascular events. This study aimed to investigate
Mehjar Azzouz, Yiyi Xu, Lars Barregard, Björn Fagerberg, Bengt Zöller, Peter Molnár, Anna Oudin, Mårten Spanne, Gunnar Engström, Leo Stockfelt   +9 more
doaj   +1 more source

Study of urinary markers of different podocytopathies by proteomic analysis

Терапевтический архив, 2023
Background. Focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy characterized by primary podocyte detection and high proteinuria. The search for biomarkers and factors associated with the progression of this disease is an important task ...
Anatoliy A. Vinogradov, Natalia V. Chebotareva, Anna E. Bugrova, Alexander G. Brzhozovskiy, Tatiana N. Krasnova, Karina Z. Nasibullina, Alexey S. Kononikhin, Sergey V. Moiseev   +7 more
doaj   +1 more source

Identification of Potential Drug Targets for Antiplatelet Therapy Specifically Targeting Platelets of Old Individuals through Proteomic Analysis

Biomedicines, 2023
Aging is a growing problem worldwide, and the prevalence and mortality of arterial and venous thromboembolism (VTE) are higher in the elderly than in the young population. To address this issue, various anticoagulants have been used. However, no evidence
Seung Hee Lee, Suyeon Cho, Jong Youl Lee, Jung Yeon Hong, Suji Kim, Myong-Ho Jeong, Won-Ho Kim   +6 more
doaj   +1 more source

INFLUENCE OF ALPHA-1-ACID GLYCOPROTEIN UPON PRODUCTION OF CYTOKINES BY PERIPHERAL BLOOD MONONUCLEARS

Медицинская иммунология, 2014
. Alpha-1-acid glycoprotein (orosomucoid) is a multifunctional acute phase reactant belonging to the family of lipocalines from plasma alpha-2 globulin fraction.
М. V. Osikov, L. V. Krivohizhina, E. V. Makarov, V. Yu. Akhmatov   +3 more
doaj   +1 more source

Inheritance of human α1-acid glycoprotein (orosomucoid) variants [PDF]

Journal of Clinical Investigation, 1969
Although variants of sialic acid-free alpha(1)-acid glycoprotein have been described in human beings, the mode of inheritance of these types has not been reported previously. With the use of a new technique of immunofixation after agarose gel electrophoresis of neuraminidase-treated whole serum, the present study demonstrates that the types of alpha(1)-
A M, Johnson, K, Schmid, C A, Alper
openaire   +2 more sources