Results 41 to 50 of about 24,134 (239)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles

Journal of Lipid Research, 2002
The CYP27 gene is expressed in arterial endothelium, macrophages, and other tissues. The gene product generates sterol intermediates that function as ligands for nuclear receptors prior to their transport to the liver for metabolism, mostly to bile acids.
Norman B. Javitt
doaj   +1 more source

Role of the nuclear receptor subfamily 4a in mast cells in the development of irritable bowel syndrome

Computational and Structural Biotechnology Journal, 2022
The activation of mast cells (MCs) and mediator release are closely related to the pathophysiology of irritable bowel syndrome (IBS). However, the exact underlying mechanisms are still not completely understood.
Ruidi Li, Shuhui Chen, Xinpei Gu, Shuhong An, Zhaojin Wang   +4 more
doaj   +1 more source

The Atypical Orphan Nuclear Receptor DAX-1 Interacts with Orphan Nuclear Receptor Nur77 and Represses Its Transactivation [PDF]

Molecular Endocrinology, 2004
DAX-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1) (NROB1) is an atypical member of the nuclear receptor family, which lacks the classical zinc finger DNA binding domain and acts as a coregulator of a number of nuclear receptors.
Kwang-Hoon, Song, Yun-Young, Park, Ki Cheol, Park, Cheol Yi, Hong, Jin Hee, Park, Minho, Shong, Keesook, Lee, Hueng-Sik, Choi   +7 more
openaire   +2 more sources

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Nuclear Orphan Receptors Control Cholesterol Catabolism [PDF]

Cell, 1999
The multiple roles of metabolites and nuclear orphan receptors in regulating cholesterol homeostasis are summarized in Figure 3Figure 3. A complex interplay of intermediates and transcription factors serves to regulate the expression of dozens of genes, all in an attempt to control the levels of potentially toxic but essential hydrophobic molecules ...
openaire   +2 more sources

The Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear Receptor [PDF]

Journal of Biological Chemistry, 2011
Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors.
X Edward, Zhou, Kelly M, Suino-Powell, Yong, Xu, Cee-Wah, Chan, Osamu, Tanabe, Schoen W, Kruse, Ross, Reynolds, James Douglas, Engel, H Eric, Xu   +8 more
openaire   +2 more sources

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

Advanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang, Tingting Qu, Qibing Sun, Ran Li, Junfei Dong, Yuming Du, Ziyin Xuan, Lei Wang, Hanli Li, Jianyun Sun, Fangliang Chen, Jinshuai Liu, Zifan Yang, Jianxiang Lei, Qian Yang, Bin Wang, Zhiming Zhou, Yu Wang   +17 more
wiley   +1 more source

The expanding roles of Nr6a1 in development and evolution

Frontiers in Cell and Developmental Biology
The Nuclear Receptor (NR) family of transcriptional regulators possess the ability to sense signalling molecules and directly couple that to a transcriptional response.
Jingxuan Li, Pauline Mascarinas, Edwina McGlinn   +2 more
doaj   +1 more source

Active nuclear receptors exhibit highly correlated AF-2 domain motions. [PDF]

PLoS Computational Biology, 2008
Nuclear receptor ligand binding domains (LBDs) convert ligand binding events into changes in gene expression by recruiting transcriptional coregulators to a conserved activation function-2 (AF-2) surface.
Denise G Teotico, Monica L Frazier, Feng Ding, Nikolay V Dokholyan, Brenda R S Temple, Matthew R Redinbo   +5 more
doaj   +1 more source