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Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland

open access: diamondJournal of Education, Health and Sport, 2021
Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir.
Konrad Kania   +4 more
doaj   +3 more sources

Pox-AbDab: the orthopoxvirus antibody database [PDF]

open access: yesFrontiers in Immunology
In August 2024, the World Health Organization declared the mpox orthopoxvirus to be a Public Health Emergency of International Concern for the second time in three years, emphasising the need for continued studies into its microbiology and potential ...
Henriette L. Capel   +4 more
doaj   +2 more sources

Vaccinia and Monkeypox Virus-Neutralizing Antibodies in People Living with HIV: A Serological Study in a Orthopoxvirus-Endemic, Low-Income Region in Brazil [PDF]

open access: yesPathogens
Co-infections of Orthopoxviruses (OPVs), such as vaccinia virus (VACV) and monkeypox virus (MPXV), and the human immunodeficiency virus (HIV) can be associated with severe outcomes.
Thyago José Silva   +10 more
doaj   +2 more sources

An Update of Orthopoxvirus Molecular Evolution

open access: yesViruses, 2022
Although variola virus (VARV) has been eradicated through widespread vaccination, other orthopoxviruses pathogenic for humans circulate in nature. Recently, new orthopoxviruses, including some able to infect humans, have been found and their complete ...
Igor V. Babkin   +2 more
doaj   +1 more source

Priming stroma with a vitamin D analog to optimize viroimmunotherapy for pancreatic cancer

open access: yesMolecular Therapy: Oncolytics, 2022
Pancreatic cancer resistance to immunotherapies is partly due to deficits in tumor-infiltrating immune cells and stromal density. Combination therapies that modify stroma and recruit immune cells are needed.
Sang-In Kim   +13 more
doaj   +1 more source

Human Monkeypox without Viral Prodrome or Sexual Exposure, California, USA, 2022

open access: yesEmerging Infectious Diseases, 2022
We report human monkeypox in a man who returned to the United States from the United Kingdom and reported no sexual contact. He had vesicular and pustular skin lesions but no anogenital involvement.
Abraar Karan   +6 more
doaj   +1 more source

Detecting, Quantifying, and Isolating Monkeypox Virus in Suspected Cases, Spain

open access: yesEmerging Infectious Diseases, 2023
When a monkeypox virus outbreak began in several parts of the world in May 2022, timely and accurate diagnosis became mandatory. In our laboratory, a real-time quantitative PCR was designed and evaluated in several patient samples and compared with ...
Marta E. Álvarez Argüelles   +9 more
doaj   +1 more source

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines

open access: yesmBio, 2023
Vaccinia virus is the active component of all modern smallpox vaccines after the mid-20th century, but it is uncertain to what extent cowpox, vaccinia, and horsepox viruses were used to produce vaccines before then.
Aline R. V. Souza   +4 more
doaj   +1 more source

The French Armed Forces Virology Unit: A Chronological Record of Ongoing Research on Orthopoxvirus

open access: yesViruses, 2017
Since the official declaration of smallpox eradication in 1980, the general population vaccination has ceased worldwide. Therefore, people under 40 year old are generally not vaccinated against smallpox and have no cross protection against orthopoxvirus ...
Déborah Delaune   +4 more
doaj   +1 more source

Ectromelia Virus Infections of Mice as a Model to Support the Licensure of Anti-Orthopoxvirus Therapeutics

open access: yesViruses, 2010
The absence of herd immunity to orthopoxviruses and the concern that variola or monkeypox viruses could be used for bioterroristic activities has stimulated the development of therapeutics and safer prophylactics.
R. Mark Buller   +4 more
doaj   +1 more source

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