Results 91 to 100 of about 13,277 (283)

Diagnostic electron microscopy in human infectious diseases – Methods and applications

Journal of Microscopy, Volume 299, Issue 3, Page 186-205, September 2025.
Abstract Diagnostic electron microscopy (EM) is indispensable in all cases of infectious diseases which deserve or profit from the detection of the entire pathogen (i.e. the infectious unit). The focus of its application has shifted during the last decades from routine diagnostics to diagnostics of special cases, emergencies and the investigation of ...
Michael Laue
wiley   +1 more source

Short-Lived Neutralizing Antibody Responses to Monkeypox Virus in Smallpox Vaccine–Naive Persons after JYNNEOS Vaccination

Emerging Infectious Diseases
JYNNEOS, a third-generation smallpox vaccine, is integral to monkeypox virus (MPXV) control efforts, but the durability of this modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccine’s effectiveness is undefined.
Kara Phipps, Jennifer Yates, Jessica Pettit, Sean Bialosuknia, Danielle Hunt, Alan P. DuPuis, Anne Payne, William Lee, Kathleen A. McDonough   +8 more
doaj   +1 more source

Systematic Review On New Face of Monkeypox Virus

Journal of Pure and Applied Microbiology, 2022
A member of the Poxviridae family of orthopoxviruses, the monkeypox virus, is the causative agent of monkeypox, The Democratic Republic of the Congo (DRC), where the disease is thought to be endemic, is one of the most common locations where it occurs in
Shilpa Rana, Pooja Negi, Meena Devi, Mansi Butola, Arif Nur Muhammad Ansori, Vikash Jakhmola   +5 more
doaj   +1 more source

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy [PDF]

, 2017
The use of high-dose interleukin-2 (IL-2) has fallen out of favor due to severe life-threatening side effects. We have recently described a unique way of directly targeting IL-2 to cytotoxic lymphocytes using a virally encoded immune evasion protein and ...
Fremont, Daved H, Ghasemi, Reza, Hein, Sarah M, Krupnick, Alexander Sasha, Lazear, Eric, Watkins, Dan, Westwick, John   +6 more
core   +2 more sources

Serologic Survey of Orthopoxvirus Infection Among Rodents in Hungary [PDF]

Vector-Borne and Zoonotic Diseases, 2015
As a result of discontinuing vaccination against smallpox after the late 1970s, different orthopoxviruses (OPVs), such as cowpox virus (CPXV), have become a re-emerging healthcare threat among zoonotic pathogens. In Hungary, data on OPV prevalence among its rodent host species have been absent.
Oldal, Miklós, Sironen, Tarja, Henttonen, Heikki, Vapalahti, Olli, Madai, Mónika, Horváth, Gyözö, Dallos, Bianka, Kutas, Anna, Földes, Fanni, Kemenesi, Gábor, Németh, Viktória, Bányai, Krisztián, Jakab, Ferenc   +13 more
openaire   +4 more sources

Titrage des anticorps contre le virus de la variole des dromadaires par la méthode de séroréduction des plages sur des cellules IB-RS2 [PDF]

, 1985
Une méthode de séroréduction des plages, sur des cellules IB-RS2 en milieu liquide, a été mise au point et utilisée pour le titrage des anticorps contre le virus de la variole des dromadaires.
Nguyen Ba Vy,, Richard, Didier
core  

Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus

Frontiers in Immunology
Modified vaccinia virus Ankara (MVA) has been widely tested in clinical trials as recombinant vector vaccine against infectious diseases and cancers in humans and animals.
Diana Diaz-Cánova, Ugo Moens, Annika Brinkmann, Andreas Nitsche, Malachy Ifeanyi Okeke   +4 more
doaj   +1 more source

MyD88-Dependent Immunity to a Natural Model of Vaccinia Virus Infection Does Not Involve Toll-Like Receptor 2. [PDF]

, 2014
UNLABELLED: Although the pattern recognition receptor Toll-like receptor 2 (TLR2) is typically thought to recognize bacterial components, it has been described to alter the induction of both innate and adaptive immunity to a number of viruses, including ...
Davies, Michael L, Eisenlohr, Laurence C., Norbury, Christopher C, Roscoe, Felicia, Sei, Janet J, Siciliano, Nicholas A, Sigal, Luis J, Xu, Ren-Huan   +7 more
core   +2 more sources

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, Volume 12, Issue 26, July 10, 2025.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

An Increasing Danger of Zoonotic Orthopoxvirus Infections

PLoS Pathogens, 2013
On May 8, 1980, the World Health Assembly at its 33(rd) session solemnly declared that the world and all its peoples had won freedom from smallpox and recommended ceasing the vaccination of the population against smallpox. Currently, a larger part of the world population has no immunity not only against smallpox but also against other zoonotic ...
openaire   +4 more sources