Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.
PLoS Computational Biology, 2016 A key feature of multicellular systems is the ability of cells to function collectively in response to external stimuli. However, the mechanisms of intercellular cell signaling and their functional implications in diverse vascular structures are poorly ...
Jian Sun +4 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2020 This article explores and summarizes recent progress in and the characterization of main players in the regulation and cyclic regeneration of hair follicles.
Patrycja Daszczuk +5 more
doaj +2 more sources
PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis [PDF]
Frontiers in ImmunologyThe relationship between calcium oscillation and cell sensitivity is poorly understood. Calcium oscillation can occur spontaneously or be triggered upon receptor-ligand binding.
Xuehua Xu +3 more
doaj +2 more sources
Cell Death Discovery, 2022 Age-related bone loss and disease strongly affect the quality of life of the elderly population. Cellular circadian rhythms have been reported to regulate bone aging, and micro RNAs (miRNAs) play crucial posttranscriptional regulatory roles in the ...
Sa Cha +5 more
doaj +2 more sources
The Roles of Fission Yeast Ase1 in Mitotic Cell Division, Meiotic Nuclear Oscillation, and Cytokinesis Checkpoint Signaling [PDF]
Molecular Biology of the Cell, 2005 The Ase1/Prc1 proteins constitute a conserved microtubule-associated protein family that is implicated in central spindle formation and cytokinesis. Here we characterize a role for fission yeast Ase1. Ase1 localizes to microtubule overlapping zones and displays dynamic alterations of localization during the cell cycle.
Akira, Yamashita +4 more
openaire +3 more sources
An agent-based model of metabolic signaling oscillations in Bacillus subtilis biofilms. [PDF]
PLoS Computational BiologyMicrobes of nearly every species can form biofilms, communities of cells bound together by a self-produced matrix. It is not understood how variation at the cellular level impacts putatively beneficial, colony-level behaviors, such as cell-to-cell ...
Obadiah J Mulder +4 more
doaj +2 more sources
A transcriptomic taxonomy of Drosophila circadian neurons around the clock
eLife, 2021 Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we ...
Dingbang Ma +6 more
doaj +2 more sources
Dynamic expression of Notch signaling genes in neural stem/progenitor cells
Frontiers in Neuroscience, 2011 In neural stem/progenitor cells, expression of the Notch effector Hes1, a transcriptional repressor, oscillates with a period of 2-3 hours by negative feedback, and Hes1 oscillations induce the oscillatory expression of the proneural gene Neurogenin2 ...
Hiromi eShimojo +2 more
doaj +2 more sources
Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation? [PDF]
Stem Cell Research & TherapyBackground Under regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca2+ oscillations), that change, especially in frequency, after the differentiation of the MSCs.
Leslie A. Vallet +8 more
doaj +2 more sources
Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. [PDF]
PLoS ONE, 2009 BACKGROUND:To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making.
Fernando Siso-Nadal +4 more
doaj +2 more sources