Signaling Pathways Underlying Muscarinic Receptor-induced [Ca2+] Oscillations in HEK293 Cells [PDF]
Journal of Biological Chemistry, 2001 We have investigated the signaling pathways underlying muscarinic receptor-induced calcium oscillations in human embryonic kidney (HEK293) cells. Activation of muscarinic receptors with a maximal concentration of carbachol (100 microm) induced a biphasic rise in cytoplasmic calcium ([Ca2+]i) comprised of release of Ca2+ from intracellular stores and ...
Dali Luo +3 more
openaire +5 more sources
Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes. [PDF]
PLoS ONE, 2008 The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1 diabetes.
Yunzhao R Ren +10 more
doaj +2 more sources
Clock-modified mesenchymal stromal cells therapy rescues molecular circadian oscillation and age-related bone loss via miR142-3p/Bmal1/YAP signaling axis [PDF]
Cell Death Discovery, 2022 Age-related bone loss and disease strongly affect the quality of life of the elderly population. Cellular circadian rhythms have been reported to regulate bone aging, and micro RNAs (miRNAs) play crucial posttranscriptional regulatory roles in the ...
Sa Cha +5 more
doaj +2 more sources
Autonomous Ca2+ Oscillations Reflect Oncogenic Signaling in B-ALL Cells
Blood, 2019 Background: Engagement of the B-cell receptor (BCR) results in Ca2+ flux and is linked to B-cell survival based on store-operated Ca2+ entry (SOCE), which is triggered by ORAI1 and stromal interaction molecule-1 (STIM1). While normal B-cells release Ca2+ only in response to external stimuli (e.g. BCR-engagement), we recently observed that transformed B-
Kohei Kume +3 more
openaire +3 more sources
A transcriptomic taxonomy of Drosophila circadian neurons around the clock
eLife, 2021 Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we ...
Dingbang Ma +6 more
doaj +2 more sources
Purinergic signalling is required for calcium oscillations in migratory chondrogenic progenitor cells [PDF]
Pflügers Archiv - European Journal of Physiology, 2014 Osteoarthritis (OA) is the most common form of chronic musculoskeletal disorders. A migratory stem cell population termed chondrogenic progenitor cells (CPC) with in vitro chondrogenic potential was previously isolated from OA cartilage. Since intracellular Ca(2+) signalling is an important regulator of chondrogenesis, we aimed to provide a detailed ...
Matta, C +8 more
openaire +8 more sources
Synergid cell calcium oscillations refine understanding of FERONIA/LORELEI signaling during interspecific hybridization [PDF]
Plant Reproduction, 2023 Abstract Key message Pollen tubes from closely related species and mutants lacking pollen tube MYB transcription factors are able to initiate FER/LRE-dependent synergid cell calcium oscillations. Abstract Reproductive isolation leads to the evolution of new species; however,
Nathaniel Ponvert, Mark A. Johnson
openaire +3 more sources
Role of Regulator of G Protein Signaling 2 (RGS2) in Ca2+ Oscillations and Adaptation of Ca2+ Signaling to Reduce Excitability of RGS2–/– Cells [PDF]
Journal of Biological Chemistry, 2004 Regulators of G protein signaling (RGS) proteins accelerate the GTPase activity of Galpha subunits to determine the duration of the stimulated state and control G protein-coupled receptor-mediated cell signaling. RGS2 is an RGS protein that shows preference toward Galpha(q).
Xiang Luo +4 more
openaire +4 more sources
PLOS ONE, 2016 Circadian clocks impact vital cardiac parameters such as blood pressure and heart rate, and adverse cardiac events such as myocardial infarction and sudden cardiac death. In mammals, the central circadian pacemaker, located in the suprachiasmatic nucleus of the hypothalamus, synchronizes cellular circadian clocks in the heart and many other tissues ...
Stephen Beesley +3 more
openaire +8 more sources
ATP-Independent Luminal Oscillations and Release of Ca2+ and H+ from Mast Cell Secretory Granules: Implications for Signal Transduction [PDF]
Biophysical Journal, 2003 InsP(3) is an important link in the intracellular information network. Previous observations show that activation of InsP(3)-receptor channels on the granular membrane can turn secretory granules into Ca(2+) oscillators that deliver periodic trains of Ca(2+) release to the cytosol (T. Nguyen, W. C. Chin, and P.
Wei-Chun Chin +2 more
openaire +4 more sources