Results 21 to 30 of about 300,586 (313)

Histamine-H1-receptor-mediated phosphoinositide hydrolysis, Ca2+ signalling and membrane-potential oscillations in human HeLa carcinoma cells [PDF]

Biochemical Journal, 1990
In human HeLa carcinoma cells, histamine causes a dose-dependent formation of inositol phosphates, production of diacylglycerol and a transient rise in intracellular [Ca2+]. These responses are completely blocked by the H1-receptor antagonist pyrilamine.
Ben C. Tilly, Leon G.J. Tertoolen, A.C. Lambrechts, R Remorie, Siegfried W. de Laat, Wouter H. Moolenaar   +5 more
openalex   +4 more sources

A case report of a family with developmental arrest of human prokaryotic stage zygote [PDF]

Frontiers in Cell and Developmental Biology
To study the genetic variation leading to the arrest phenotype of pronuclear (PN) zygotes. We recruited a family characterized by recurrent PN arrest during in vitro fertilization (IVF) and intracytoplasmic sperm injection cycles (ICSI) and performed ...
Tianzhong Ma, Songxia Zhou, Xuezhen Xie, Jingyao Chen, Jing Wang, Guohong Zhang   +5 more
doaj   +2 more sources

Autonomous Ca2+ Oscillations Reflect Oncogenic BCR-Signaling in Multiple B-Cell Malignancies and Are Essential for Survival and Proliferation

Blood, 2018
Abstract Background: Nuclear factor of activated T cells (NFAT) factors regulate activation and Ca2+ signaling in B-cells. Store-operated Ca2+ entry (SOCE) is regulated by Orai1 and Stim1 and upstream of NFAT. We previously reported on the observation of autonomous oscillatory Ca2+ signal activity in BCR-ABL1-driven B-ALL. Autonomous Ca2+
Kohei Kume, Liting Chen, Jae-Woong Lee, Markus Müschen   +3 more
openalex   +3 more sources

Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes

Acta Biochimica et Biophysica Sinica, 2021
The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min, Wu Xiaoan, Du Genlai, Chen Weiyi, Zhang Quanyou   +4 more
doaj   +1 more source

Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

Frontiers in Physics, 2021
Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu, Fei Xu, Zhiyong Yin, Ligang Zhu, Jun Jin, Qingzhu He, Qingzhu He, Xiang Li, Xiang Li, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai   +12 more
doaj   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Nature Communications, 2023
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup   +7 more
doaj   +1 more source

Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development

Cell Death and Disease, 2022
Molecular clocks operate in peripheral tissues, including endocrine glands, and play important regulatory roles in this context. However, potential age-related changes in the expression rhythmicity of clock genes and the effects of these changes on the ...
Junguee Lee, Hae Joung Sul, Hyunsu Choi, Dong Hyun Oh, Minho Shong   +4 more
doaj   +1 more source

Self-propelled deformable particle model for keratocyte galvanotaxis [PDF]

Biophys. J. p130-142 January 03, 2023, 2022
During wound healing, fish keratocyte cells undergo galvanotaxis where they follow a wound-induced electric field. In addition to their stereotypical persistent motion, keratocytes can develop circular motion without a field or oscillate around the field direction.
arxiv   +1 more source

Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways

Bioengineering, 2023
Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis. Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation of ERK and Akt.
Kenneth K. Y. Ho, Siddhartha Srivastava, Patrick C. Kinnunen, Krishna Garikipati, Gary D. Luker, Kathryn E. Luker   +5 more
doaj   +1 more source