Results 21 to 30 of about 1,299,623 (327)

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Nature Communications, 2023
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup   +7 more
doaj   +1 more source

Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development

Cell Death and Disease, 2022
Molecular clocks operate in peripheral tissues, including endocrine glands, and play important regulatory roles in this context. However, potential age-related changes in the expression rhythmicity of clock genes and the effects of these changes on the ...
Junguee Lee, Hae Joung Sul, Hyunsu Choi, Dong Hyun Oh, Minho Shong   +4 more
doaj   +1 more source

Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways

Bioengineering, 2023
Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis. Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation of ERK and Akt.
Kenneth K. Y. Ho, Siddhartha Srivastava, Patrick C. Kinnunen, Krishna Garikipati, Gary D. Luker, Kathryn E. Luker   +5 more
doaj   +1 more source

Adrenergic regulation of immune cell function and inflammation

Seminars in Immunopathology, 2020
The sympathetic nervous system integrates the functions of multiple organ systems by regulating their autonomic physiological activities. The immune system is regulated both locally and systemically by the neurotransmitters epinephrine and norepinephrine
D. Sharma, J. D. Farrar
semanticscholar   +1 more source

Computational modeling of the interplay between cadherin-mediated cell adhesion and Wnt signaling pathway. [PDF]

PLoS ONE, 2014
Wnt signaling and cadherin-mediated adhesion have been implicated in both processes of embryonic development and the progression of carcinomas. Recent experimental studies revealed that Wnt signaling and cadherin-mediated cell adhesion have close ...
Jiawen Chen, Zhong-Ru Xie, Yinghao Wu
doaj   +1 more source

Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. [PDF]

, 2016
Transcription factor nuclear factor kappa B (NF-κB) shows cooperative switch-like activation followed by prolonged oscillatory nuclear translocation in response to extracellular stimuli.
Aihara, Kazuyuki, Behar, Marcelo, Hoffmann, Alexander, Inoue, Kentaro, Okada-Hatakeyama, Mariko, Shinohara, Hisaaki, Tanaka, Gouhei, Yumoto, Noriko   +7 more
core   +1 more source

Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]

, 2016
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz, A Burgalossi, A Nadler, A Nadler, A Wuttke, AC Newton, Alexander Gottschalk, C Yang, Carsten Schultz, CI Bargmann, CJ Nolan, D Toullec, DA Jacobson, DA Jacobson, David J Hodson, DB Konrad, Dirk Trauner, Dmytro A Yushchenko, E Oancea, F Plenge-Tellechea, F Varoqueaux, FM Ashcroft, G Reither, GA Rutter, Guy A Rutter, H Fliegl, H Ishihara, J Basu, J Das, JA Frank, JA Lewis, James Allen Frank, Jatin Nagpal, JD Violin, JD Violin, JE Toettcher, Jeong-Seop Rhee, JM Herbert, JS Rhee, JT Fleming, KDB Wierda, L Coussens, M Almena, M Putyrski, MA Ravier, MA Ravier, MS Pessin, N Brose, N Brose, N Brose, Nils Brose, Noa Lipstein, P Bergsten, PA Marignani, PA Wender, PK Dadi, RJ Davis, S Brenner, S Corbalán-García, S Feng, T Hofmann, TR Mahoney, U Kikkawa, X Lou, Y Kurohane Kaneko, Y Zhao   +65 more
core   +3 more sources

Synchronization of oscillatory growth prepares fungal hyphae for fusion

eLife, 2023
Communication is crucial for organismic interactions, from bacteria, to fungi, to humans. Humans may use the visual sense to monitor the environment before starting acoustic interactions.
Valentin Wernet, Marius Kriegler, Vojtech Kumpost, Ralf Mikut, Lennart Hilbert, Reinhard Fischer   +5 more
doaj   +1 more source

Blockage of spontaneous Ca2+ oscillation causes cell death in intraerythrocitic Plasmodium falciparum. [PDF]

PLoS ONE, 2012
Malaria remains one of the world's most important infectious diseases and is responsible for enormous mortality and morbidity. Resistance to antimalarial drugs is a challenging problem in malaria control.
Masahiro Enomoto, Shin-ichiro Kawazu, Satoru Kawai, Wakako Furuyama, Tohru Ikegami, Jun-ichi Watanabe, Katsuhiko Mikoshiba   +6 more
doaj   +1 more source

Multiplexing oscillatory biochemical signals [PDF]

, 2013
In recent years it is increasingly being recognized that biochemical signals are not necessarily constant in time and that the temporal dynamics of a signal can be the information carrier.
de Ronde, Wiet, Wolde, Pieter Rein ten
core   +2 more sources