Results 21 to 30 of about 1,311,722 (333)

Immediate nuclear accumulation of BMAL1 to regulate cellular circadian clock synchronization [PDF]

Communications Biology
Cell-autonomous circadian clocks coordinate daily physiological timing, allowing them to synchronize with the environment. However, the initial signaling events shared by diverse synchronizing cues remain elusive.
Teruya Tamaru, Genki Kawamura, Hikari Yoshitane, Satoshi Koinuma, Yoshitaka Fukada, Atsuhiko Naito, Takeaki Ozawa, Ken Takamatsu   +7 more
doaj   +2 more sources

Synchronization of the segmentation clock using synthetic cell-cell signaling. [PDF]

Genes Dev
Tight coordination of cell-cell signaling in space and time is vital for self-organization in tissue patterning. During vertebrate development, the segmentation clock drives oscillatory gene expression in the presomitic mesoderm (PSM), leading to the ...
Isomura A, Asanuma D, Kageyama R.
europepmc   +2 more sources

Cholesterol-induced robust Ca oscillation in astrocytes required for survival and lipid droplet formation in high-cholesterol condition

iScience, 2022
Summary: Cholesterol, one of the major cell membrane components, stabilizes membrane fluidity and regulates signal transduction. Beside its canonical roles, cholesterol has been reported to directly activate signaling pathways such as hedgehog (Hh).
Chihiro Adachi, Shio Otsuka, Takafumi Inoue   +2 more
doaj   +1 more source

Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes

Acta Biochimica et Biophysica Sinica, 2021
The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.
Zhang Min, Wu Xiaoan, Du Genlai, Chen Weiyi, Zhang Quanyou   +4 more
doaj   +1 more source

Oscillations in a cAMP signalling model for cell aggregation – a geometric analysis [PDF]

Journal of Mathematical Analysis and Applications, 2020
In this article, the authors perform a geometric analysis of a singularly perturbed model for a cyclic adenosine monophosphate (cAMP) signalling system that controls aggregation of the amoeboid microorganism \textit{Dictyostelium discoideum} and which can be rewritten into the form of a planar system of ordinary differential equations with two small ...
Miao, Zhouqian, Popovic, Nikola, Szmolyan, Peter   +2 more
openaire   +3 more sources

Oscillations and temporal signalling in cells [PDF]

Physical Biology, 2007
The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models.
G. Tiana, S. Krishna, S. Pigolotti, M. H. Jensen, K. Sneppen   +4 more
openaire   +5 more sources

Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

Frontiers in Physics, 2021
Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how oscillation behavior is involved and required for necroptosis remain elusive.
Fei Xu, Fei Xu, Zhiyong Yin, Ligang Zhu, Jun Jin, Qingzhu He, Qingzhu He, Xiang Li, Xiang Li, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai, Jianwei Shuai   +12 more
doaj   +1 more source

Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development

Nature Communications, 2023
Notch signaling is crucial for pancreatic cell fate choice. With mathematical modeling and experiments, Xu et al. provides new insights into how different Notch ligands and Hes1 oscillation guide the spatial-temporal dynamics of cell differentiation.
Xiaochan Xu, Philip Allan Seymour, Kim Sneppen, Ala Trusina, Anuska la Rosa Egeskov-Madsen, Mette Christine Jørgensen, Mogens Høgh Jensen, Palle Serup   +7 more
doaj   +1 more source

Adrenergic regulation of immune cell function and inflammation

Seminars in Immunopathology, 2020
The sympathetic nervous system integrates the functions of multiple organ systems by regulating their autonomic physiological activities. The immune system is regulated both locally and systemically by the neurotransmitters epinephrine and norepinephrine
D. Sharma, J. D. Farrar
semanticscholar   +1 more source

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration [PDF]

Nature Cell Biology, 2013
It is generally believed that cytoskeletal activities drive random cell migration, whereas signal transduction events initiated by receptors regulate the cytoskeleton to guide cells. However, we find that the cytoskeletal network, involving SCAR/WAVE, Arp 2/3 and actin-binding proteins, is capable of generating only rapid oscillations and undulations ...
Chuan-Hsiang Huang, Ming Tang, Changji Shi, Pablo A. Iglesias, Peter N. Devreotes   +4 more
openaire   +2 more sources