Results 21 to 30 of about 1,282,481 (350)

Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles [PDF]

BMC Research Notes
Objective The developing mammalian retina initially contains undifferentiated cells, providing a model for investigating the mechanisms of differentiation.
Yoshitoku Watabe, Sakurako Kobayashi, Satoru Takahashi, Masaharu Yoshihara   +3 more
doaj   +2 more sources

Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations [PDF]

Journal of Biological Chemistry, 2003
Recent studies indicate novel roles for the ubiquitous ion pump, Na,K-ATPase, in addition to its function as a key regulator of intracellular sodium and potassium concentration. We have previously demonstrated that ouabain, the endogenous ligand of Na,K-ATPase, can trigger intracellular Ca2+ oscillations, a versatile intracellular signal controlling a ...
Katsuhiko Mikoshiba, Mark Lal, Ayako Miyakawa-Naito, Per Uhlén, Oleg Aizman, Sergey Zelenin, Anita Aperia, Hjalmar Brismar   +7 more
openaire   +5 more sources

Dynamic expression of Notch signaling genes in neural stem/progenitor cells

Frontiers in Neuroscience, 2011
In neural stem/progenitor cells, expression of the Notch effector Hes1, a transcriptional repressor, oscillates with a period of 2-3 hours by negative feedback, and Hes1 oscillations induce the oscillatory expression of the proneural gene Neurogenin2 ...
Hiromi eShimojo, Toshiyuki eOhtsuka, Ryoichiro eKageyama   +2 more
doaj   +2 more sources

Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca2+ signaling in human retinal pigment epithelial cells [PDF]

Scientific Reports, 2017
AbstractVertebrate eyes are known to contain circadian clocks, however, the intracellular mechanisms regulating the retinal clockwork remain largely unknown. To address this, we generated a cell line (hRPE-YC) from human retinal pigmental epithelium, which stably co-expressed reporters for molecular clock oscillations (Bmal1-luciferase) and ...
Masayuki Ikeda, Rina Ikarashi, Alsawaf Ahmad, Kouhei Takeuchi, Eri Morioka, Yuzuki Kanda, Takashi Sugiyama, Honami Akechi, Masaaki Ikeda, Takashi Ebisawa   +9 more
openaire   +3 more sources

Study of the Synchronization and Transmission of Intracellular Signaling Oscillations in Cells Using Bispectral Analysis

Biology
The oscillation synchronization analysis in biological systems will expand our knowledge about the response of living systems to changes in environmental conditions. This knowledge can be used in medicine (diagnosis, therapy, monitoring) and agriculture (increasing productivity, resistance to adverse effects).
Maxim E. Astashev, Dmitriy A. Serov, Arina V. Tankanag, Inna V. Knyazeva, Artem A. Dorokhov, Alexander V. Simakin, Sergey V. Gudkov   +6 more
openaire   +4 more sources

Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation? [PDF]

Stem Cell Research & Therapy
Background Under regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca2+ oscillations), that change, especially in frequency, after the differentiation of the MSCs.
Leslie A. Vallet, Marina Sánchez-Petidier, Romain Fernandes, Nataliia Naumova, Caterina Merla, Claudia Consales, Giorgia Innamorati, Franck M. André, Lluis M. Mir   +8 more
doaj   +2 more sources

Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP. [PDF]

PLoS ONE, 2009
BACKGROUND:To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making.
Fernando Siso-Nadal, Jeffrey J Fox, Stéphane A Laporte, Terence E Hébert, Peter S Swain   +4 more
doaj   +2 more sources

Repetitive mitochondrial Ca 2+ signals synchronize with cytosolic Ca 2+ oscillations in the pancreatic beta-cell line, MIN6 [PDF]

Diabetologia, 1998
We examined the relationship between cytosolic Ca2+ concentration ([Ca2+]c) and mitochondrial matrix Ca2+ concentration ([Ca2+]m) in the pancreatic beta-cell line, MIN6. [Ca2+]c was monitored in a single or a group (30 cells) of fura-2-loaded MIN6 cells, and [Ca2+]m was measured in a group (1 x 10[6] cells) of MIN6 cells stably transfected with ...
Tomoichiro Asano, Jun-ichi Miyazaki, Hisamitsu Ishihara, Toshihiko Yada, Mitsuhiro Nakazaki, Masatoshi Kikuchi, Kouichi Inukai, Yoshitomo Oka, Masafumi Kakei, Hiromitsu Tanaka   +9 more
openaire   +5 more sources

IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts [PDF]

Scientific Reports
Insulin-like growth factor (IGF)-I mediates long-term activities that determine cell fate, including cell proliferation and differentiation. This study aimed to characterize the mechanisms by which IGF-I determines cell fate from the aspect of IGF-I ...
Ryosuke Okino, Kazuaki Mukai, Shunpei Oguri, Masato Masuda, Satoshi Watanabe, Yosuke Yoneyama, Sumine Nagaosa, Takafumi Miyamoto, Atsushi Mochizuki, Shin-Ichiro Takahashi, Fumihiko Hakuno   +10 more
doaj   +2 more sources

Origins of Ultrasensitivity and Complex Signaling Dynamics of Cellular Hydrogen Peroxide and Peroxiredoxin [PDF]

Antioxidants
Hydrogen peroxide (H2O2) plays a crucial role in cell signaling in response to physiological and environmental perturbations. H2O2 can oxidize typical 2-Cys peroxiredoxin (PRX) first into a sulfenic acid, which resolves into a disulfide that can be ...
Shengnan Liu, Jingbo Pi, Qiang Zhang
doaj   +2 more sources