Results 61 to 70 of about 1,299,623 (327)

The role of calcium oscillations in the phenotype selection in endothelial cells

Scientific Reports, 2021
Angiogenesis is an important process in the formation and maintenance of tissues which is driven by a complex system of intracellular and intercellular signaling mechanisms.
Birses Debir, Cameron Meaney, Mohammad Kohandel, M. Burcin Unlu   +3 more
doaj   +1 more source

Multiscale modeling of oscillations and spiral waves in Dictyostelium populations

, 2014
Unicellular organisms exhibit elaborate collective behaviors in response to environmental cues. These behaviors are controlled by complex biochemical networks within individual cells and coordinated through cell-to-cell communication.
Gregor, Thomas, Mehta, Pankaj, Noorbakhsh, Javad, Schwab, David, Sgro, Allyson   +4 more
core   +1 more source

Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation [PDF]

, 2003
Neural stem cells can generate in vitro progenitors of the three main cell lineages found in the CNS. The signaling pathways underlying the acquisition of differentiated phenotypes in these cells are poorly understood.
Berridge, Michael J., Bootman, Martin D., Ciccolini, Francesca, Collins, Tony J., Lipp, Peter, Sudhoelter, Juliana   +5 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts

Scientific Reports
Insulin-like growth factor (IGF)-I mediates long-term activities that determine cell fate, including cell proliferation and differentiation. This study aimed to characterize the mechanisms by which IGF-I determines cell fate from the aspect of IGF-I ...
Ryosuke Okino, Kazuaki Mukai, Shunpei Oguri, Masato Masuda, Satoshi Watanabe, Yosuke Yoneyama, Sumine Nagaosa, Takafumi Miyamoto, Atsushi Mochizuki, Shin-Ichiro Takahashi, Fumihiko Hakuno   +10 more
doaj   +1 more source

CDPKs CPK6 and CPK3 function in ABA regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure.

PLoS Biology, 2006
Abscisic acid (ABA) signal transduction has been proposed to utilize cytosolic Ca(2+) in guard cell ion channel regulation. However, genetic mutants in Ca(2+) sensors that impair guard cell or plant ion channel signaling responses have not been ...
Izumi C Mori, Yoshiyuki Murata, Yingzhen Yang, Shintaro Munemasa, Yong-Fei Wang, Shannon Andreoli, Hervé Tiriac, Jose M Alonso, Jeffery F Harper, Joseph R Ecker, June M Kwak, Julian I Schroeder   +11 more
doaj   +1 more source

Circadian regulation of dentate gyrus excitability mediated by G-protein signaling

Cell Reports, 2023
Summary: The central circadian regulator within the suprachiasmatic nucleus transmits time of day information by a diurnal spiking rhythm driven by molecular clock genes controlling membrane excitability.
Jose Carlos Gonzalez, Haeun Lee, Angela M. Vincent, Angela L. Hill, Lacy K. Goode, Gwendalyn D. King, Karen L. Gamble, Jacques I. Wadiche, Linda Overstreet-Wadiche   +8 more
doaj   +1 more source

A new multicompartmental reaction-diffusion modeling method links transient membrane attachment of E. coli MinE to E-ring formation [PDF]

, 2009
Many important cellular processes are regulated by reaction-diffusion (RD) of molecules that takes place both in the cytoplasm and on the membrane. To model and analyze such multicompartmental processes, we developed a lattice-based Monte Carlo method ...
A Minton, A Szabo, AD Dupuy, AV Popov, AV Popov, B Huang, B Treanor, C Sanford, CA Gomez-Uribe, CH Hansen, CL Woldringh, CL Woldringh, CV Rao, D Fange, D Greenfield, D Hall, D Ramos, D Ridgway, D Ridgway, DA Drew, DC Clarke, DM Morris, DM Raskin, DM Raskin, DT Gillespie, DT Gillespie, DW Adams, EN Cytrynbaum, F Tostevin, FC Collins, G Balgi, G Meacci, G Meacci, GF King, GF King, GG Szpiro, H Meinhardt, H Zhou, H Zhou, H Zhou, J Derr, J Elf, J Hattne, J Lutkenhaus, J Sung, JA Dix, JC Schaff, JS Zon van, JV Rodriguez, K Kruse, K Takahashi, K Takahashi, KC Huang, L Boulianne, L Ma, M Ander, M Fernandez-Suarez, M Gibson, M Howard, M Howard, M Loose, M Smoluchowski von, Masaru Tomita, MT Klann, N Ji, N Pavin, P Borowski, P Rangamani, RA Kerr, RJ Ellis, S Pichoff, S Schaub, S Wils, S Zimmerman, Satya Nanda Vel Arjunan, SB Albada van, SL Rowland, SNV Arjunan, SR Neves, SS Andrews, T Ideker, TG Bernhardt, U Resch-Genger, Y Shih, Y Shih, Y Zhang, Z Hu, Z Hu, Z Hu, Z Hu   +89 more
core   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Distinct anti-dyskinetic effects of amantadine and group II metabotropic glutamate receptor agonist LY354740 in a rodent model: An electrophysiological perspective

Neurobiology of Disease, 2020
L-DOPA-induced dyskinesia (LID) is a major complication of long-term dopamine replacement therapy in Parkinson's disease. Characteristic neural oscillation and abnormal activity of striatal projection neurons (SPNs) are typical pathological events of LID,
Cong Zheng, Yan Xu, Guiqin Chen, Yang Tan, Weiqi Zeng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Zhentao Zhang, Xuebing Cao   +10 more
doaj   +1 more source