Collective cell migration of Dictyostelium without cAMP oscillations at multicellular stages
Communications Biology, 2019 In Dictyostelium discoideum, a model organism for the study of collective cell migration, extracellular cyclic adenosine 3’,5’-monophosphate (cAMP) acts as a diffusible chemical guidance cue for cell aggregation, which has been thought to be important in
Hidenori Hashimura +3 more
semanticscholar +1 more source
Microgravity influences circadian clock oscillation in human keratinocytes [PDF]
, 2015 Microgravity and sudden changes of gravitational forces exert numerous effects on tissues, organs and apparatus. Responses to these forces variably applied to cells indicate the existence of mechan- otransduction pathways able to modulate transcription ...
Avitabile +29 more
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Experimental Design for Stochastic Models of Nonlinear Signaling Pathways Using an Interval-Wise Linear Noise Approximation and State Estimation. [PDF]
PLoS ONE, 2016 BACKGROUND:Computational modeling is a key technique for analyzing models in systems biology. There are well established methods for the estimation of the kinetic parameters in models of ordinary differential equations (ODE).
Christoph Zimmer
doaj +1 more source
Journal of Circadian Rhythms, 2023 The circadian clock regulates the “push-pull” of the molecular signaling mechanisms that arrange the rhythmic organization of the physiology to maintain cellular homeostasis. In mammals, molecular clock genes tightly arrange cellular rhythmicity.
Yalcin Erzurumlu +2 more
doaj +1 more source
p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]
, 2013 The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina +7 more
core +2 more sources
Miro1-dependent mitochondrial dynamics in parvalbumin interneurons
eLife, 2021 The spatiotemporal distribution of mitochondria is crucial for precise ATP provision and calcium buffering required to support neuronal signaling.
Georgina Kontou +9 more
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G protein-coupled receptor signalling in astrocytes in health and disease: A focus on metabotropic glutamate receptors [PDF]
, 2012 Work published over the past 10–15 years has caused the neuroscience community to engage in a process of constant re-evaluation of the roles of glial cells in the mammalian central nervous system.
Bradley, Sophie J., Challiss, R.A. John
core +1 more source
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Science, 2017 Light, fat, and commensals The gut microbiota facilitates energy harvest from food and transfers it into fat storage. Working in mice, Wang et al.
Yuhao Wang +5 more
semanticscholar +1 more source
Lattice gas cellular automata model for rippling and aggregation in myxobacteria
, 2004 A lattice-gas cellular automaton (LGCA) model is used to simulate rippling and aggregation in myxobacteria. An efficient way of representing cells of different cell size, shape and orientation is presented that may be easily extended to model later ...
Buchard +32 more
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Frontiers in Cell and Developmental Biology, 2019 The mammalian target of rapamycin (mTOR) is an evolutionarily conserved kinase which assembles a signaling network that integrates diverse biochemical and mechanical cues to coordinate cell growth and proliferation.
Shan-Shan Lin, Ya-Wen Liu, Ya-Wen Liu
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