Results 61 to 70 of about 1,311,722 (333)

Mechanical Stretch Induces mTOR Recruitment and Activation at the Phosphatidic Acid-Enriched Macropinosome in Muscle Cell

Frontiers in Cell and Developmental Biology, 2019
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved kinase which assembles a signaling network that integrates diverse biochemical and mechanical cues to coordinate cell growth and proliferation.
Shan-Shan Lin, Ya-Wen Liu, Ya-Wen Liu
doaj   +1 more source

Multiscale modeling of oscillations and spiral waves in Dictyostelium populations

, 2014
Unicellular organisms exhibit elaborate collective behaviors in response to environmental cues. These behaviors are controlled by complex biochemical networks within individual cells and coordinated through cell-to-cell communication.
Gregor, Thomas, Mehta, Pankaj, Noorbakhsh, Javad, Schwab, David, Sgro, Allyson   +4 more
core   +1 more source

Model simplification of signal transduction pathway networks via a hybrid inference strategy [PDF]

, 2008
A full-scale mathematical model of cellular networks normally involves a large number of variables and parameters. How to effectively develop manageable and reliable models is crucial for effective computation, analysis and design of such systems.
Asthagiri, Bhalla, Cheong, Conzelmann, Conzelmann, Covert, Dano, Degenring, Fell, Heinrich, Hoffmann, Hoffmann, Ihekwaba, Ingalls, Jia, Kearns, Krishna, Kruger, Lipniacki, Liu, Mauryaa, Nelson, Neves, O'Dea, Werner, Wildermuth, Yue   +26 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Activation of nuclear Ca2+-dependent gene expression by CRAC channel Ca2+ nanodomains

Cell Reports
Summary: Oscillations in the levels of second messengers are observed throughout the phylogenetic tree, with signaling information encoded in the frequency of the spikes.
Yu-Ping Lin, Abdull J. Massri, Yi-Ting Huang, Sara A. Grimm, Anant B. Parekh   +4 more
doaj   +1 more source

Circadian Oscillation Pattern of Endoplasmic Reticulum Quality Control (ERQC) Components in Human Embryonic Kidney HEK293 Cells

Journal of Circadian Rhythms, 2023
The circadian clock regulates the “push-pull” of the molecular signaling mechanisms that arrange the rhythmic organization of the physiology to maintain cellular homeostasis. In mammals, molecular clock genes tightly arrange cellular rhythmicity.
Yalcin Erzurumlu, Deniz Catakli, Hatice Kubra Dogan   +2 more
doaj   +1 more source

Sequential pattern formation governed by signaling gradients

, 2016
Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the interplay of ...
Jörg, David J., Jülicher, Frank, Oates, Andrew C.   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Miro1-dependent mitochondrial dynamics in parvalbumin interneurons

eLife, 2021
The spatiotemporal distribution of mitochondria is crucial for precise ATP provision and calcium buffering required to support neuronal signaling.
Georgina Kontou, Pantelis Antonoudiou, Marina Podpolny, Blanka R Szulc, I Lorena Arancibia-Carcamo, Nathalie F Higgs, Guillermo Lopez-Domenech, Patricia C Salinas, Edward O Mann, Josef T Kittler   +9 more
doaj   +1 more source

Lattice gas cellular automata model for rippling and aggregation in myxobacteria

, 2004
A lattice-gas cellular automaton (LGCA) model is used to simulate rippling and aggregation in myxobacteria. An efficient way of representing cells of different cell size, shape and orientation is presented that may be easily extended to model later ...
Buchard, Börner, Dworkin, Gronewold, Hagen, Hodgkin, Hodgkin, Igoshin, Jelsbak, Jelsbak, Jiang, Julien, Kim, Kim, Kim, Kim, Kim, Kroos, Kruse, Li, Lutscher, Marée, Reichenbach, Sager, Sager, Shi, Shimkets, Shimkets, Shimkets, Stevens, Vasquez, Welch, Wolgemuth   +32 more
core   +1 more source