Results 11 to 20 of about 24,935 (185)

Antiviral Resistance Associated With Multiple Mutations Occurring in Seasonal Influenza A(H3N2) Virus in a Patient Treated With Oseltamivir [PDF]

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Our case highlights the importance of early diagnosis in respiratory illness and timely detection of drug resistance so that antiviral treatment can be initiated and modified, particularly for high‐risk groups. Vaccination and early, carefully dosed antiviral treatment are key to mitigating severe influenza cases, especially in ...
Saira Hussain, Christina Guo, Yi‐Mo Deng, Nikita Deshpande, Presa Chanthalavanh, Natalie Spirason, Lauren Burmas, Heidi Peck, Bradley J. Gardiner, Ian G. Barr   +9 more
wiley   +2 more sources

Oseltamivir drug‐disease modelling in infants with influenza virus infection [PDF]

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3214-3222, September 2026.
Abstract Aims Oseltamivir is a commonly used neuraminidase inhibitor for treatment of influenza infection, but little data exist regarding concentration‐response relationships. Methods Pharmacokinetic (PK) and viral dynamic data from an earlier NIAID Collaborative Antiviral Study Group trial in paediatric patients with influenza from 0–23 months of age
Kun Wang, David W. Kimberlin, Richard J. Whitley, Edward P. Acosta, For the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group   +4 more
wiley   +2 more sources

Oseltamivir Enhances Hippocampal Network Synchronization

Journal of Pharmacological Sciences, 2008
Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown.
Atsushi Usami, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki, Yuji Ikegaya   +10 more
doaj   +2 more sources

Oseltamivir

Journal of Postgraduate Medicine, 2009
Oseltamivir, a selective neuraminidase enzyme inhibitor, has gained worldwide attention in view of Influenza A (H1N1) pandemic. It is one of the most important drugs effective against the novel influenza virus. Oseltamivir is used for the treatment of uncomplicated acute illness due to influenza infection.
Tullu, M. S.
core   +4 more sources

Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

Drug Design, Development and Therapy, 2017
Kyungho Jang,1,2,* Min-Kyoung Kim,3,4,* Jaeseong Oh,1 SeungHwan Lee,1 Joo-Youn Cho,1 Kyung-Sang Yu,1 Tai Kiu Choi,3 Sang-Hyuk Lee,3,4 Kyoung Soo Lim4 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine ...
Jang K, Kim M, Oh J, Lee S, Cho JY, Yu KS, Choi TK, Lee SH, Lim KS   +8 more
doaj   +1 more source

Plasma concentrations of oseltamivir and oseltamivir carboxylate in critically ill children on extracorporeal membrane oxygenation support. [PDF]

PLoS ONE, 2010
INTRODUCTION: To evaluate the effect of extracorporeal membrane oxygenation (ECMO) support on pharmacokinetics of oseltamivir and oseltamivir carboxylate (OC) in children.
Enno D Wildschut, Matthijs de Hoog, Maurice J Ahsman, Dick Tibboel, Albert D M E Osterhaus, Pieter L A Fraaij   +5 more
doaj   +4 more sources

Environmental levels of oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards – implications for the risk of an oseltamivir resistant influenza pandemic

Resistance in influenza is a growing problem. Oseltamivir carboxylate (OC), the active substance of the most widely used antiviral drug oseltamivir (Tamiflu ®), is poorly degraded in sewage treatment plants and surface water.
Grabic, Roman, Latorre-Margalef, Neus, Fick, Jerker, Muradrasoli, Shaman, Lennerstrand, Johan, Wahlgren, John, Järhult, Josef,, Orozovic, Goran, Gunnarsson, Gunnar, Lundkvist, Åke, Olsen, Björn, Bröjer, Caroline, Waldenström, Jonas, Söderström, Hanna   +13 more
core   +9 more sources

A Cross-Sectional Study of Psychiatric Manifestations Following Oseltamivir Administration for Suspected Patients with H1N1 Swine Influenza Infection [PDF]

Journal of Cardio-Thoracic Medicine, 2022
Introduction: Oseltamivir is an antiviral drug used to treat H1N1 influenza. FDA added a warning to the label of oseltamivir drawing attention to the risk of developing neuropsychiatric adverse events.
Basavaraju Jayadeva, Shankar Kumar, Sushmitha Kota, Aashik Shekar   +3 more
doaj   +1 more source

A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir

Virology Journal, 2010
Background Oseltamivir is the preferred antiviral drug for influenza, but oseltamivir-resistant A(H1N1) viruses have circulated worldwide since the 2007-2008 influenza season.
Itagaki Tsutomu, Takashita Emi, Sugawara Kanetsu, Sanjoh Kanako, Abiko Chieko, Suto Asuka, Aoki Yoko, Mizuta Katsumi, Matsuzaki Yoko, Katsushima Yuriko, Ujike Makoto, Obuchi Masatsugu, Odagiri Takato, Tashiro Masato   +13 more
doaj   +1 more source

Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness. [PDF]

PLoS ONE, 2015
Oseltamivir phosphate is a widely used anti-influenza sialidase inhibitor. Sialylation, governed by sialyltransferases and sialidases, is strongly implicated in the oncogenesis and progression of breast cancer.
Joana T de Oliveira, Ana L Santos, Catarina Gomes, Rita Barros, Cláudia Ribeiro, Nuno Mendes, Augusto J de Matos, M Helena Vasconcelos, Maria José Oliveira, Celso A Reis, Fátima Gärtner   +10 more
doaj   +1 more source