Results 31 to 40 of about 34,354 (193)

The anti-influenza drug oseltamivir evokes hypothermia in mice through dopamine D2 receptor activation via central actions

Journal of Pharmacological Sciences, 2018
Oseltamivir has a hypothermic effect in mice when injected intraperitoneally (i.p.) and intracerebroventricularly (i.c.v.). Here we show that the hypothermia evoked by i.c.v.-oseltamivir is inhibited by non-selective dopamine receptor antagonists ...
Akihiro Fukushima, Arisa Fukui, Yuki Takemura, Yasuhiro Maeda, Hideki Ono   +4 more
doaj   +1 more source

Simultaneous quantification of prodrug oseltamivir and its metabolite oseltamivir carboxylate in human plasma by LC–MS/MS to support a bioequivalence study

Journal of Pharmaceutical Analysis, 2013
A simple, precise and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the simultaneous determination of oseltamivir and oseltamivir carboxylate, a neuraminidase inhibitor, using their ...
Ajay Gupta, Swati Guttikar, Pranav S. Shrivastav, Mallika Sanyal   +3 more
doaj   +1 more source

Acute Cheilitis Associated with Oseltamivir after Influenzae A Infection

Case Reports in Pediatrics, 2023
Oseltamivir is a neuraminidase inhibitor used to treat acute influenza A or B in adult and pediatric patients. Adverse reactions are usually mild. Here, we report novel side effects associated with oseltamivir.
Koji Yokoyama, Mitsukazu Mamada
doaj   +1 more source

Exacerbation of neuropsychiatric symptoms in an adult male with influenza A virus treated with oseltamivir [PDF]

Mental Health Clinician
Oseltamivir (Tamiflu) package labeling has a warning for neuropsychiatric adverse events (NPAE), most commonly in children and adolescents, especially males.
Masa Scott, PharmD, BCPS, BCPP, Emily Faltin, PharmD, MBA, Kathleen Londick, PharmD   +2 more
doaj   +1 more source

Efficacy of baloxavir marboxil on household transmission of influenza infection

Journal of Pharmaceutical Health Care and Sciences, 2020
Background Baloxavir marboxil (baloxavir) is a new anti-influenza virus agent that is comparable to oseltamivir phosphate (oseltamivir). Since the efficacy of baloxavir in preventing household transmission of influenza is not well established, we ...
Takumi Umemura, Yoshikazu Mutoh, Takato Kawamura, Masayuki Saito, Takahito Mizuno, Aiko Ota, Koji Kozaki, Tetsuya Yamada, Yoshiaki Ikeda, Toshihiko Ichihara   +9 more
doaj   +1 more source

Does C-reactive protein predict time to recovery and benefit from oseltamivir treatment in primary care patients with influenza-like illness? A randomized controlled trial secondary analysis

Scandinavian Journal of Primary Health Care, 2021
Objective Recovery time and treatment effect of oseltamivir in influenza-like illness (ILI) differs between patient groups. A point-of-care test to better predict ILI duration and identify patients who are most likely to benefit from oseltamivir ...
Nicolay Jonassen Harbin, Karin Rystedt, Morten Lindbaek, Ruta Radzeviciene, Johan Westin, Ronny Gunnarsson, Christopher C. Butler, Alike W. van der Velden, Theo J. Verheij, Pär-Daniel Sundvall   +9 more
doaj   +1 more source

Dose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug [PDF]

, 2014
BACKGROUND: Dose selection is an important step in pharmacokinetic (PK) studies of hemodialysis patients. We propose a simulation-based dose-selection method for PK studies of hemodialysis patients using a subpharmacological dose of oseltamivir as a ...
Chun-Soo Lim, Dong Ki Kim, Jay Wook Lee, Jung Pyo Lee, Kook-Hwan Oh, Kwang-Hee Shin, Kwon Wook Joo, Kyung-Sang Yu, Myounghee Kim, Sejoong Kim, Yon Su Kim   +10 more
core   +1 more source

Effectiveness of early oseltamivir treatment in children with pandemic 2009 A/H1N1 influenza in the Vilnius University Children Hospital

Acta Medica Lituanica, 2013
Background. Oseltamivir is recommended for treatment of pandemic influenza in children. The therapy should be started as soon as possible, however, data on the effectiveness of such a treatment is rather limited.
Vytautas Usonis, Irena Narkevičiūtė, Vilija Guntaitė   +2 more
doaj   +1 more source

Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets. [PDF]

PLoS Pathogens, 2010
The neuraminidase (NA) inhibitor oseltamivir offers an important immediate option for the control of influenza, and its clinical use has increased substantially during the recent H1N1 pandemic.
Susu Duan, David A Boltz, Patrick Seiler, Jiang Li, Karoline Bragstad, Lars P Nielsen, Richard J Webby, Robert G Webster, Elena A Govorkova   +8 more
doaj   +1 more source

Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia

ERJ Open Research, 2021
Background The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed.
Gerard Moreno, Alejandro Rodríguez, Jordi Sole-Violán, Ignacio Martín-Loeches, Emili Díaz, María Bodí, Luis F. Reyes, Josep Gómez, Juan Guardiola, Sandra Trefler, Loreto Vidaur, Elisabet Papiol, Lorenzo Socias, Carolina García-Vidal, Eudald Correig, Judith Marín-Corral, Marcos I. Restrepo, Jonathan S. Nguyen-Van-Tam, Antoni Torres   +18 more
doaj   +1 more source