Results 31 to 40 of about 25,524 (191)

Simultaneous quantification of prodrug oseltamivir and its metabolite oseltamivir carboxylate in human plasma by LC–MS/MS to support a bioequivalence study

Journal of Pharmaceutical Analysis, 2013
A simple, precise and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method has been developed and validated for the simultaneous determination of oseltamivir and oseltamivir carboxylate, a neuraminidase inhibitor, using their ...
Ajay Gupta, Swati Guttikar, Pranav S. Shrivastav, Mallika Sanyal   +3 more
doaj   +1 more source

Environmental levels of oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards – implications for the risk of an oseltamivir resistant influenza pandemic

Resistance in influenza is a growing problem. Oseltamivir carboxylate (OC), the active substance of the most widely used antiviral drug oseltamivir (Tamiflu ®), is poorly degraded in sewage treatment plants and surface water.
Grabic, Roman, Latorre-Margalef, Neus, Fick, Jerker, Muradrasoli, Shaman, Lennerstrand, Johan, Wahlgren, John, Järhult, Josef,, Orozovic, Goran, Gunnarsson, Gunnar, Lundkvist, Åke, Olsen, Björn, Bröjer, Caroline, Waldenström, Jonas, Söderström, Hanna   +13 more
core   +4 more sources

Efficacy of baloxavir marboxil on household transmission of influenza infection

Journal of Pharmaceutical Health Care and Sciences, 2020
Background Baloxavir marboxil (baloxavir) is a new anti-influenza virus agent that is comparable to oseltamivir phosphate (oseltamivir). Since the efficacy of baloxavir in preventing household transmission of influenza is not well established, we ...
Takumi Umemura, Yoshikazu Mutoh, Takato Kawamura, Masayuki Saito, Takahito Mizuno, Aiko Ota, Koji Kozaki, Tetsuya Yamada, Yoshiaki Ikeda, Toshihiko Ichihara   +9 more
doaj   +1 more source

Early oseltamivir treatment improves survival in critically ill patients with influenza pneumonia

ERJ Open Research, 2021
Background The relationship between early oseltamivir treatment (within 48 h of symptom onset) and mortality in patients admitted to intensive care units (ICUs) with severe influenza is disputed.
Gerard Moreno, Alejandro Rodríguez, Jordi Sole-Violán, Ignacio Martín-Loeches, Emili Díaz, María Bodí, Luis F. Reyes, Josep Gómez, Juan Guardiola, Sandra Trefler, Loreto Vidaur, Elisabet Papiol, Lorenzo Socias, Carolina García-Vidal, Eudald Correig, Judith Marín-Corral, Marcos I. Restrepo, Jonathan S. Nguyen-Van-Tam, Antoni Torres   +18 more
doaj   +1 more source

Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets. [PDF]

PLoS Pathogens, 2010
The neuraminidase (NA) inhibitor oseltamivir offers an important immediate option for the control of influenza, and its clinical use has increased substantially during the recent H1N1 pandemic.
Susu Duan, David A Boltz, Patrick Seiler, Jiang Li, Karoline Bragstad, Lars P Nielsen, Richard J Webby, Robert G Webster, Elena A Govorkova   +8 more
doaj   +1 more source

Effectiveness of early oseltamivir treatment in children with pandemic 2009 A/H1N1 influenza in the Vilnius University Children Hospital

Acta Medica Lituanica, 2013
Background. Oseltamivir is recommended for treatment of pandemic influenza in children. The therapy should be started as soon as possible, however, data on the effectiveness of such a treatment is rather limited.
Vytautas Usonis, Irena Narkevičiūtė, Vilija Guntaitė   +2 more
doaj   +1 more source

Determination of Oseltamivir Quality by Colorimetric and Liquid Chromatographic Methods

Emerging Infectious Diseases, 2008
We developed a colorimetric and chromatographic assay for oseltamivir to assess the authenticity of Tamiflu (F. Hoffmann-La Roche Ltd., Basel, Switzerland) because of a growing concern about counterfeit oseltamivir. The colorimetric assay is quantitative
Michael D. Green, Henry Nettey, Robert A. Wirtz   +2 more
doaj   +1 more source

The impact of medication shortages on paediatric care: A retrospective impact analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Medication shortages are a growing global concern, with potentially greater consequences in paediatric patients because of the limited availability of safe, evidence‐based and appropriately formulated medication. This study aimed to evaluate the impact of medication shortages on paediatric patients by assessing the suitability and safety of ...
Maaike Johanna Rutten ‐ van Kranenburg, Laurens Christiaan van Rijn, Elisabeth Johanna Ruijgrok, Sinno Henricus Paulus Simons, Brigitta Carolina Maria Witjes, Jan‐Dietert Christoffer Brugma, Robert Bernard Flint   +6 more
wiley   +1 more source

Emergence and Fixing of Antiviral Resistance in Influenza A Via Recombination and Hitch Hiking [PDF]

, 2009
The dramatic rise of oseltamivir resistance in the H1N1 serotype in the 2007/2008 season and the fixing of H274Y in the 2008/2009 season has raised concerns regarding individuals at risk for seasonal influenza, as well as development of similar ...
Henry L. Niman
core  

Selection for resistance to oseltamivir in seasonal and pandemic H1N1 influenza and widespread co-circulation of the lineages

International Journal of Health Geographics, 2010
Background In Spring 2009, a novel reassortant strain of H1N1 influenza A emerged as a lineage distinct from seasonal H1N1. On June 11, the World Heath Organization declared a pandemic - the first since 1968. There are currently two main branches of H1N1
Treseder Travis W, Alexandrov Boyan B, Hardman Jori, Studer Jonathon, Voronkin Igor O, Janies Daniel A, Valson Chandni   +6 more
doaj   +1 more source